We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Autonomic Manifestations: cardiac arrhythmias | Improves | -2.96 |
| Blood Type: O Positive | Worsen | 2.96 |
| Comorbid: Fibromyalgia | Improves | -2.96 |
| Comorbid: High Anxiety | Worsen | 2.96 |
| Comorbid: Small intestinal bacterial overgrowth (SIBO) | Improves | -2.41 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.63 |
| General: Headaches | Improves | -2.41 |
| Immune Manifestations: Abdominal Pain | Improves | -2.41 |
| Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 2.96 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -2.41 |
| Neurological: Impairment of concentration | Improves | -2.41 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.96 |
| Onset: Gradual | Improves | -2.63 |
| Pain: Chest pain | Worsen | 2.96 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| ADHD | Worsen | 2.96 |
| Alzheimer's disease | Improves | -2.96 |
| Ankylosing spondylitis | Worsen | 3.21 |
| Atherosclerosis | Improves | -2.71 |
| Autoimmune Disease | Worsen | 1.28 |
| Carcinoma | Worsen | 2.63 |
| Chronic Fatigue Syndrome | Improves | -2.44 |
| Colorectal Cancer | Worsen | 2.98 |
| Coronary artery disease | Worsen | 2.63 |
| Crohn's Disease | Improves | -2.63 |
| cystic fibrosis | Worsen | 3.57 |
| Depression | Worsen | 3.92 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.37 |
| Gout | Worsen | 2.96 |
| High Blood Pressure | Worsen | 2.37 |
| Histamine Issues | Worsen | 2.43 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.96 |
| Inflammatory Bowel Disease | Worsen | 2.43 |
| Irritable Bowel Syndrome | Worsen | 2.21 |
| Liver Cirrhosis | Worsen | 3.52 |
| ME/CFS without IBS | Worsen | 3.08 |
| Multiple Sclerosis | Worsen | 3.45 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -2.89 |
| Rheumatoid arthritis | Worsen | 2.44 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 3.62 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 2.21 |
| Stress / posttraumatic stress disorder | Worsen | 2.63 |
| Systemic Lupus Erythematosus | Worsen | 2.96 |
| Type 2 Diabetes | Worsen | 2.63 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.