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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Asymptomatic: No Health Issues	Worsen	1.6
Autonomic Manifestations: cardiac arrhythmias	Worsen	3.5
Comorbid-Mouth: Dry Mouth	Worsen	0
Comorbid-Mouth: Mouth Sores	Worsen	3.17
Comorbid: Constipation and Explosions (not diarrohea)	Worsen	2.56
Immune Manifestations: Abdominal Pain	Worsen	2.48
Immune Manifestations: tender lymph nodes	Worsen	2.9
Neurocognitive: Slowness of thought	Worsen	2.48
Neurocognitive: Unable to focus vision and/or attention	Worsen	2.56
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-2.9
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	Worsen	3.12
Neuroendocrine: Feeling like you have a low temperature	Worsen	0
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Worsen	2.56
Neurological-Vision: inability to focus eye/vision	Worsen	2.56
Neurological: Difficulty reading	Worsen	2.56
Neurological: emotional overload	Worsen	3.12
Neurological: fasciculations	Worsen	0
Neurological: High degree of Empathy before onset	Worsen	0
Neurological: Short-term memory issues	Worsen	2.63
Neurological: Spatial instability and disorientation	Worsen	0
Onset: Gradual	Worsen	3.12
Pain: Aching of the eyes or behind the eyes	Worsen	2.63
Post-exertional malaise: General	Worsen	0
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	0
Post-exertional malaise: Physically drained or sick after mild activity	Worsen	0
Post-exertional malaise: Post-exertional malaise	Worsen	0
Post-exertional malaise: Rapid cognitive fatigability,	Worsen	0
Post-exertional malaise: Worsening of symptoms after mild mental activity	Worsen	0

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Allergic Rhinitis (Hay Fever)	Worsen	2.22
Allergies	Worsen	2.07
Alzheimer's disease	Worsen	3.29
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	0
Ankylosing spondylitis	Improves	-4.82
Asthma	Improves	-2.9
Atherosclerosis	Improves	-3.9
Autism	Improves	-2.77
Barrett esophagus cancer	Worsen	2.83
Brain Trauma	Worsen	2.55
Carcinoma	Improves	-2.66
Celiac Disease	Improves	-2.4
Chronic Fatigue Syndrome	Worsen	1.42
Chronic Kidney Disease	Improves	-2.41
Chronic urticaria (Hives)	Improves	-4
Colorectal Cancer	Improves	-4.53
Crohn's Disease	Improves	-4.3
cystic fibrosis	Worsen	1.17
Depression	Improves	-2.85
Epilepsy	Improves	-2.83
Fibromyalgia	Worsen	2.9
gallstone disease (gsd)	Improves	-2.9
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Worsen	3.46
Generalized anxiety disorder	Improves	-3.52
Graves' disease	Improves	-2.69
High Blood Pressure	Worsen	0
Histamine Issues	Improves	-2.01
IgA nephropathy (IgAN)	Worsen	2.9
Inflammatory Bowel Disease	Improves	-3.63
Irritable Bowel Syndrome	Improves	-3.47
Liver Cirrhosis	Improves	-3.83
ME/CFS with IBS	Improves	-3.91
ME/CFS without IBS	Improves	-3.84
Mood Disorders	Worsen	0
Multiple Sclerosis	Worsen	3.18
Multiple system atrophy (MSA)	Worsen	1.55
neuropsychiatric disorders (PANDAS, PANS)	Worsen	1.31
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-2.9
NonCeliac Gluten Sensitivity	Improves	-1.48
Obesity	Improves	-2.74
Osteoporosis	Improves	-3.34
Parkinson's Disease	Worsen	3.43
Psoriasis	Improves	-3.79
Rheumatoid arthritis	Worsen	4.18
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Worsen	2.73
Rosacea	Worsen	2.03
Schizophrenia	Worsen	2.9
Sclerosis	Worsen	2.9
Sjögren syndrome	Improves	-3.3
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-3.2
Stress / posttraumatic stress disorder	Improves	-3.61
Systemic Lupus Erythematosus	Worsen	2.38
Type 1 Diabetes	Worsen	3.42
Type 2 Diabetes	Worsen	3.51
Ulcerative colitis	Improves	-0.46

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.