We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 50-60 | Worsen | 1.51 |
Age: 60-70 | Improves | -0.09 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.82 |
Autism: Official Diagnosis | Worsen | 3.75 |
Autonomic Manifestations: Orthostatic intolerance | Improves | -3.53 |
Autonomic: Graying or blacking out after standing | Improves | -1.76 |
Autonomic: Shortness of breath | Improves | -2.86 |
Blood Type: A Positive | Worsen | 1.76 |
Blood Type: O Positive | Worsen | 2.23 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.91 |
Comorbid-Mouth: Dry Mouth | Worsen | 2.37 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.63 |
Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.22 |
Comorbid: High Anxiety | Worsen | 1.51 |
Comorbid: Histamine or Mast Cell issues | Worsen | 3.63 |
Comorbid: Hypothyroidism | Worsen | 2.91 |
Comorbid: Inflammatory bowel disease | Improves | -2.78 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 3 |
Condition: ME/CFS with IBS | Worsen | 3.01 |
DePaul University Fatigue Questionnaire : Fatigue | Improves | -2.52 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.88 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.49 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 2.01 |
General: Fatigue | Improves | -2.79 |
General: Myalgia (pain) | Improves | -1.36 |
General: Sinus issues with headaches | Worsen | 3.01 |
Immune Manifestations: Alcohol Intolerant | Worsen | 2.91 |
Immune Manifestations: medication sensitivities. | Improves | -2.48 |
Immune: Tender / sore lymph nodes | Worsen | 2.88 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 3.14 |
Infection: Mycoplasma | Worsen | 2.91 |
Infection: Parasite - Other | Worsen | 3.63 |
Joint: Redness | Improves | -2.82 |
Joint: Stiffness and swelling | Worsen | 2.81 |
Joint: Tenderness | Improves | -2.7 |
Neurocognitive: Can only focus on one thing at a time | Worsen | 3.47 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.63 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
Neuroendocrine Manifestations: recurrent feelings of feverishness | Improves | -2.79 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.47 |
Neuroendocrine: Alcohol intolerance | Worsen | 4.23 |
Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.92 |
Neurological-Sleep: Insomnia | Improves | -2.92 |
Neurological-Vision: inability to focus eye/vision | Worsen | 3.01 |
Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 3.63 |
Neurological: Cognitive/Sensory Overload | Improves | -2.26 |
Neurological: Difficulty reading | Worsen | 2.91 |
Neurological: emotional overload | Worsen | 2.74 |
Neurological: fasciculations | Worsen | 2.74 |
Neurological: High degree of Empathy before onset | Worsen | 2.74 |
Neurological: Joint hypermobility | Improves | -2.82 |
Neurological: Short-term memory issues | Worsen | 2.47 |
Neurological: Spatial instability and disorientation | Worsen | 2.74 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.29 |
Official Diagnosis: Autoimmune Disease | Improves | -2.92 |
Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.92 |
Official Diagnosis: Mast Cell Dysfunction | Worsen | 3 |
Onset: Gradual | Improves | -1.95 |
Pain: Sensitivity to pain | Worsen | 2.91 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.98 |
Post-exertional malaise: General | Worsen | 2.74 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.33 |
Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.74 |
Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
Sleep: Need to nap daily | Worsen | 2.52 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.91 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Improves | -3.47 |
ADHD | Worsen | 2.88 |
Allergies | Worsen | 0.3 |
Alzheimer's disease | Improves | -4.05 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.74 |
Ankylosing spondylitis | Worsen | 3.53 |
Asthma | Worsen | 3.48 |
Atherosclerosis | Improves | -4.51 |
Autism | Improves | -4.68 |
Barrett esophagus cancer | Worsen | 1.46 |
Brain Trauma | Improves | -3.96 |
Carcinoma | Worsen | 0 |
Celiac Disease | Improves | -2.88 |
Chronic Fatigue Syndrome | Improves | -4.81 |
Chronic Kidney Disease | Improves | -3.68 |
Chronic urticaria (Hives) | Improves | -1.63 |
Colorectal Cancer | Worsen | 2.36 |
Coronary artery disease | Improves | -3.27 |
Crohn's Disease | Worsen | 2.56 |
Depression | Worsen | 3.02 |
Epilepsy | Improves | -3.47 |
Fibromyalgia | Improves | -3.41 |
Functional constipation / chronic idiopathic constipation | Improves | -3.01 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
Graves' disease | Worsen | 2.74 |
Hashimoto's thyroiditis | Worsen | 2.99 |
High Blood Pressure | Improves | -3.72 |
Histamine Issues | Worsen | 1.21 |
Histamine Issues From Ubiome | Improves | -2.72 |
Hyperlipidemia (High Blood Fats) | Worsen | 1.3 |
IgA nephropathy (IgAN) | Improves | -3.9 |
Inflammatory Bowel Disease | Improves | -3.87 |
Insomnia | Improves | -2.31 |
Irritable Bowel Syndrome | Improves | -4.86 |
Liver Cirrhosis | Improves | -4.98 |
ME/CFS with IBS | Improves | -3.78 |
ME/CFS without IBS | Improves | -2.88 |
Mood Disorders | Improves | -2.74 |
Multiple Sclerosis | Worsen | 2.06 |
Multiple system atrophy (MSA) | Worsen | 2.52 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.57 |
Obesity | Improves | -2.23 |
Osteoporosis | Worsen | 2.72 |
Parkinson's Disease | Improves | -2.18 |
Psoriasis | Worsen | 2.88 |
Rheumatoid arthritis | Improves | -3.93 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 2.54 |
Rosacea | Improves | -1.97 |
Schizophrenia | Worsen | 4.26 |
Sjögren syndrome | Improves | -2.88 |
Stress / posttraumatic stress disorder | Improves | -2.77 |
Systemic Lupus Erythematosus | Worsen | 1.46 |
Type 1 Diabetes | Improves | -3.97 |
Type 2 Diabetes | Improves | -0.76 |
Ulcerative colitis | Worsen | 1.91 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.