We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 50-60 | Worsen | 1.51 |
| Age: 60-70 | Improves | -0.09 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.82 |
| Autism: Official Diagnosis | Worsen | 3.75 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -3.53 |
| Autonomic: Graying or blacking out after standing | Improves | -1.76 |
| Autonomic: Shortness of breath | Improves | -2.86 |
| Blood Type: A Positive | Worsen | 1.76 |
| Blood Type: O Positive | Worsen | 2.23 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.91 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.37 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.63 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.22 |
| Comorbid: High Anxiety | Worsen | 1.51 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 3.63 |
| Comorbid: Hypothyroidism | Worsen | 2.91 |
| Comorbid: Inflammatory bowel disease | Improves | -2.78 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 3 |
| Condition: ME/CFS with IBS | Worsen | 3.01 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -2.52 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.88 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.49 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 2.01 |
| General: Fatigue | Improves | -2.79 |
| General: Myalgia (pain) | Improves | -1.36 |
| General: Sinus issues with headaches | Worsen | 3.01 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 2.91 |
| Immune Manifestations: medication sensitivities. | Improves | -2.48 |
| Immune: Tender / sore lymph nodes | Worsen | 2.88 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 3.14 |
| Infection: Mycoplasma | Worsen | 2.91 |
| Infection: Parasite - Other | Worsen | 3.63 |
| Joint: Redness | Improves | -2.82 |
| Joint: Stiffness and swelling | Worsen | 2.81 |
| Joint: Tenderness | Improves | -2.7 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 3.47 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.63 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: recurrent feelings of feverishness | Improves | -2.79 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.47 |
| Neuroendocrine: Alcohol intolerance | Worsen | 4.23 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.92 |
| Neurological-Sleep: Insomnia | Improves | -2.92 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 3.01 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 3.63 |
| Neurological: Cognitive/Sensory Overload | Improves | -2.26 |
| Neurological: Difficulty reading | Worsen | 2.91 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Joint hypermobility | Improves | -2.82 |
| Neurological: Short-term memory issues | Worsen | 2.47 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.29 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.92 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.92 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 3 |
| Onset: Gradual | Improves | -1.95 |
| Pain: Sensitivity to pain | Worsen | 2.91 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.98 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.33 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.74 |
| Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Need to nap daily | Worsen | 2.52 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.91 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -3.47 |
| ADHD | Worsen | 2.88 |
| Allergies | Worsen | 0.3 |
| Alzheimer's disease | Improves | -4.05 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.74 |
| Ankylosing spondylitis | Worsen | 3.53 |
| Asthma | Worsen | 3.48 |
| Atherosclerosis | Improves | -4.51 |
| Autism | Improves | -4.68 |
| Barrett esophagus cancer | Worsen | 1.46 |
| Brain Trauma | Improves | -3.96 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -2.88 |
| Chronic Fatigue Syndrome | Improves | -4.81 |
| Chronic Kidney Disease | Improves | -3.68 |
| Chronic urticaria (Hives) | Improves | -1.63 |
| Colorectal Cancer | Worsen | 2.36 |
| Coronary artery disease | Improves | -3.27 |
| Crohn's Disease | Worsen | 2.56 |
| Depression | Worsen | 3.02 |
| Epilepsy | Improves | -3.47 |
| Fibromyalgia | Improves | -3.41 |
| Functional constipation / chronic idiopathic constipation | Improves | -3.01 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Worsen | 2.99 |
| High Blood Pressure | Improves | -3.72 |
| Histamine Issues | Worsen | 1.21 |
| Histamine Issues From Ubiome | Improves | -2.72 |
| Hyperlipidemia (High Blood Fats) | Worsen | 1.3 |
| IgA nephropathy (IgAN) | Improves | -3.9 |
| Inflammatory Bowel Disease | Improves | -3.87 |
| Insomnia | Improves | -2.31 |
| Irritable Bowel Syndrome | Improves | -4.86 |
| Liver Cirrhosis | Improves | -4.98 |
| ME/CFS with IBS | Improves | -3.78 |
| ME/CFS without IBS | Improves | -2.88 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 2.06 |
| Multiple system atrophy (MSA) | Worsen | 2.52 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.57 |
| Obesity | Improves | -2.23 |
| Osteoporosis | Worsen | 2.72 |
| Parkinson's Disease | Improves | -2.18 |
| Psoriasis | Worsen | 2.88 |
| Rheumatoid arthritis | Improves | -3.93 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 2.54 |
| Rosacea | Improves | -1.97 |
| Schizophrenia | Worsen | 4.26 |
| Sjögren syndrome | Improves | -2.88 |
| Stress / posttraumatic stress disorder | Improves | -2.77 |
| Systemic Lupus Erythematosus | Worsen | 1.46 |
| Type 1 Diabetes | Improves | -3.97 |
| Type 2 Diabetes | Improves | -0.76 |
| Ulcerative colitis | Worsen | 1.91 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.