We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.9 |
| Age: 60-70 | Improves | -1.7 |
| Autism: Official Diagnosis | Worsen | 1.76 |
| Autonomic Manifestations: cardiac arrhythmias | Improves | -3.5 |
| Autonomic: Graying or blacking out after standing | Improves | -1.76 |
| Blood Type: A Positive | Worsen | 2.42 |
| Blood Type: O Positive | Worsen | 2.42 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.37 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 1.76 |
| Comorbid: High Anxiety | Worsen | 0.02 |
| Comorbid: Histamine or Mast Cell issues | Improves | -1.7 |
| Comorbid: Inflammatory bowel disease | Worsen | 1.96 |
| Comorbid: Migraine | Worsen | 4.07 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.9 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 0.02 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.97 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.56 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 3.63 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 4.37 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.59 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.66 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.37 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.97 |
| Gender: Male | Worsen | 1.27 |
| General: Fatigue | Improves | -1.79 |
| General: Headaches | Improves | -1.62 |
| General: Heavy feeling in arms and legs | Improves | -2.88 |
| General: Sinus issues with headaches | Worsen | 2.95 |
| Immune Manifestations: tender lymph nodes | Improves | -2.9 |
| Immune: Chronic Sinusitis | Worsen | 2.95 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.76 |
| Joint: Stiffness and swelling | Improves | -1.7 |
| Joint: Tenderness | Worsen | 2.8 |
| Neurocognitive: Brain Fog | Worsen | 2.95 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -1.68 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -3.43 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.95 |
| Neuroendocrine: Alcohol intolerance | Improves | -1.7 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neuroendocrine: Lack of appetite | Improves | -2.88 |
| Neurological-Sleep: Sleep Apnea | Worsen | 2.95 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 0 |
| Neurological-Vision: Blurred Vision | Improves | -2.93 |
| Neurological: Cognitive/Sensory Overload | Improves | -1.64 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: fasciculations | Improves | -3.32 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Short-term memory issues | Worsen | 2.47 |
| Neurological: Slowed speech | Improves | -1.61 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 1.76 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -1.69 |
| Onset: Gradual | Improves | -1.95 |
| Pain: Eye pain | Improves | -2.9 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.48 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.74 |
| Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Problems staying asleep | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -4.08 |
| ADHD | Worsen | 4.28 |
| Allergies | Worsen | 3.08 |
| Alzheimer's disease | Improves | -3.91 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -3.17 |
| Ankylosing spondylitis | Worsen | 4.71 |
| Asthma | Worsen | 2.72 |
| Atherosclerosis | Worsen | 4.63 |
| Autism | Improves | -5.03 |
| Barrett esophagus cancer | Improves | -2.53 |
| Brain Trauma | Worsen | 1.29 |
| Carcinoma | Worsen | 2.83 |
| Celiac Disease | Improves | -3.56 |
| Chronic Fatigue Syndrome | Improves | -4.39 |
| Chronic Kidney Disease | Improves | -2.53 |
| Chronic urticaria (Hives) | Worsen | 3.5 |
| Colorectal Cancer | Worsen | 3.48 |
| Coronary artery disease | Improves | -3.1 |
| Crohn's Disease | Worsen | 3.08 |
| cystic fibrosis | Worsen | 2.99 |
| Depression | Improves | -1.31 |
| Epilepsy | Improves | -3.49 |
| Fibromyalgia | Improves | -3.47 |
| gallstone disease (gsd) | Worsen | 2.83 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -3.56 |
| Graves' disease | Improves | -1.16 |
| Hashimoto's thyroiditis | Improves | -3.31 |
| High Blood Pressure | Improves | -2.18 |
| Histamine Issues | Worsen | 1.66 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| hypercholesterolemia (High Cholesterol) | Improves | -2.22 |
| Hyperlipidemia (High Blood Fats) | Worsen | 4.04 |
| hypertension (High Blood Pressure | Worsen | 3.71 |
| IgA nephropathy (IgAN) | Improves | -3.84 |
| Inflammatory Bowel Disease | Worsen | 2.11 |
| Insomnia | Worsen | 3.64 |
| Irritable Bowel Syndrome | Improves | -4.35 |
| Juvenile idiopathic arthritis | Worsen | 2.99 |
| Liver Cirrhosis | Improves | -3.59 |
| ME/CFS with IBS | Worsen | 2.78 |
| ME/CFS without IBS | Worsen | 3.02 |
| Metabolic Syndrome | Improves | -2.9 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 4.55 |
| Multiple system atrophy (MSA) | Worsen | 2.7 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.65 |
| Obesity | Improves | -2.16 |
| Osteoporosis | Worsen | 2.72 |
| Parkinson's Disease | Worsen | 5.29 |
| Psoriasis | Worsen | 3.53 |
| Rheumatoid arthritis | Improves | -3.07 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 2.7 |
| Rosacea | Worsen | 4.22 |
| Schizophrenia | Worsen | 4.11 |
| Sjögren syndrome | Improves | -0.63 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 2.83 |
| Stress / posttraumatic stress disorder | Improves | -3.51 |
| Systemic Lupus Erythematosus | Improves | -4.37 |
| Type 1 Diabetes | Worsen | 1.91 |
| Type 2 Diabetes | Improves | -3.89 |
| Ulcerative colitis | Improves | -4.18 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.