We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 60-70 | Improves | -2.68 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.95 |
| Asymptomatic: No Health Issues | Worsen | 0.17 |
| Autonomic Manifestations: irritable bowel syndrome | Worsen | 1.48 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -2.95 |
| Autonomic: Inability to tolerate an upright position | Improves | -2.95 |
| Autonomic: Irregular heartbeats | Improves | -2.95 |
| Blood Type: A Positive | Improves | -3.4 |
| Blood Type: O Positive | Improves | -3.69 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.95 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.81 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -2.39 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.22 |
| Comorbid: High Anxiety | Improves | -3.54 |
| Comorbid: Histamine or Mast Cell issues | Improves | -1.64 |
| Comorbid: Hypothyroidism | Improves | -2.95 |
| Comorbid: Inflammatory bowel disease | Improves | -3.54 |
| Comorbid: Migraine | Improves | -3.2 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.54 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.11 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 1.65 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -3.45 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.2 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -3.69 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -3.25 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.12 |
| General: Headaches | Worsen | 2.53 |
| General: Myalgia (pain) | Worsen | 3.43 |
| Immune Manifestations: Abdominal Pain | Improves | -2.1 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 2.21 |
| Immune Manifestations: Bloating | Improves | -2.95 |
| Immune Manifestations: Inflammation (General) | Improves | -2.95 |
| Immune Manifestations: medication sensitivities. | Worsen | 1.48 |
| Joint: Redness | Improves | -3.2 |
| Joint: Stiffness and swelling | Improves | -2.68 |
| Neurocognitive: Brain Fog | Improves | -2.95 |
| Neurocognitive: Difficulty understanding things | Improves | -1.41 |
| Neurocognitive: Problems remembering things | Improves | -2.95 |
| Neurocognitive: Slowness of thought | Worsen | 2.48 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -2.95 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.25 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -3.69 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 2.81 |
| Neuroendocrine: Alcohol intolerance | Improves | -2.68 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -2.95 |
| Neurological-Sleep: Insomnia | Improves | -2.95 |
| Neurological-Vision: Blurred Vision | Worsen | 2.73 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.95 |
| Neurological: Difficulty reading | Improves | -3.54 |
| Neurological: Dysautonomia | Improves | -1.4 |
| Neurological: Joint hypermobility | Improves | -2.95 |
| Neurological: Slowed speech | Worsen | 2.2 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -3.43 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.95 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.95 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -3.41 |
| Onset: 2010-2020 | Improves | -2.95 |
| Pain: Chest pain | Worsen | 1.89 |
| Pain: Joint pain | Worsen | 1.56 |
| Sleep: Daytime drowsiness | Improves | -2.95 |
| Sleep: Problems staying asleep | Worsen | 1.7 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -2.68 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| ADHD | Worsen | 3.11 |
| Allergic Rhinitis (Hay Fever) | Improves | -3.27 |
| Allergies | Worsen | 3.8 |
| Alzheimer's disease | Worsen | 2.29 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -3.39 |
| Ankylosing spondylitis | Worsen | 2.59 |
| Asthma | Improves | -3.56 |
| Atherosclerosis | Worsen | 3.2 |
| Autism | Worsen | 1.59 |
| Bipolar Disorder | Improves | -3.23 |
| Brain Trauma | Improves | -1.47 |
| Carcinoma | Worsen | 2.81 |
| Celiac Disease | Worsen | 3.74 |
| Cerebral Palsy | Improves | -2.9 |
| Chronic Fatigue Syndrome | Improves | -3.99 |
| Chronic Kidney Disease | Worsen | 2.61 |
| Chronic Urticaria (Hives) | Improves | -2.9 |
| Colorectal Cancer | Improves | -5.25 |
| Coronary artery disease | Worsen | 1.44 |
| Crohn's Disease | Improves | -3.52 |
| Depression | Improves | -4.3 |
| Epilepsy | Improves | -3.64 |
| Fibromyalgia | Improves | -3.75 |
| Functional constipation / chronic idiopathic constipation | Improves | -2.87 |
| gallstone disease (gsd) | Improves | -2.63 |
| Graves' disease | Worsen | 2.97 |
| High Blood Pressure | Worsen | 2.82 |
| Histamine Issues From Ubiome | Worsen | 2.2 |
| Hyperlipidemia (High Blood Fats) | Worsen | 2.97 |
| IgA nephropathy (IgAN) | Worsen | 4.22 |
| Inflammatory Bowel Disease | Worsen | 3.8 |
| Irritable Bowel Syndrome | Worsen | 3.08 |
| Liver Cirrhosis | Worsen | 4.84 |
| ME/CFS with IBS | Improves | -3.6 |
| ME/CFS without IBS | Improves | -3.68 |
| Mood Disorders | Improves | -2.97 |
| Multiple Sclerosis | Worsen | 3.53 |
| Multiple system atrophy (MSA) | Improves | -1.72 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.97 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 2.07 |
| Obesity | Worsen | 3.64 |
| Osteoarthritis | Improves | -2.9 |
| Osteoporosis | Worsen | 3.01 |
| Parkinson's Disease | Improves | -4.65 |
| Psoriasis | Improves | -2.07 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 2.35 |
| Rosacea | Worsen | 2.9 |
| Schizophrenia | Worsen | 2.76 |
| Sjögren syndrome | Worsen | 3.62 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.14 |
| Stress / posttraumatic stress disorder | Improves | -3.93 |
| Systemic Lupus Erythematosus | Worsen | 2.79 |
| Type 1 Diabetes | Worsen | 3.77 |
| Type 2 Diabetes | Improves | -4.23 |
| Ulcerative colitis | Improves | -3.78 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.