We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.48 |
| Age: 60-70 | Worsen | 2.8 |
| Asymptomatic: No Health Issues | Worsen | 2.53 |
| Autism: Official Diagnosis | Worsen | 1.95 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -3.05 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -1.84 |
| Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Improves | -2.63 |
| Autonomic: Graying or blacking out after standing | Improves | -1.76 |
| Autonomic: Heart rate increase after standing | Improves | -3.05 |
| Autonomic: Inability to tolerate an upright position | Worsen | 2.85 |
| Autonomic: Shortness of breath | Improves | -2.73 |
| Blood Type: A Positive | Improves | -2.2 |
| Blood Type: O Positive | Worsen | 3.06 |
| Comorbid-Mouth: Dry Mouth | Improves | -1.76 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 1.76 |
| Comorbid: High Anxiety | Worsen | 2.85 |
| Comorbid: Inflammatory bowel disease | Worsen | 2.89 |
| Comorbid: Migraine | Worsen | 2.85 |
| Comorbid: Mold Sensitivity / Exposure | Improves | -3.05 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 0.02 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.54 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 2.99 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 3.46 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.58 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.68 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.64 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.59 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.53 |
| General: Myalgia (pain) | Improves | -2.61 |
| General: Sinus issues with headaches | Worsen | 2.95 |
| Immune Manifestations: Abdominal Pain | Worsen | 2.48 |
| Immune Manifestations: medication sensitivities. | Improves | -3.05 |
| Immune: Chronic Sinusitis | Worsen | 2.95 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 2.92 |
| Infection: Mycoplasma | Worsen | 2.82 |
| Joint: Tenderness | Worsen | 2.85 |
| Neurocognitive: Brain Fog | Worsen | 2.95 |
| Neurocognitive: Slowness of thought | Worsen | 2.48 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -2.82 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -3.05 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: Rapid muscular fatiguability | Improves | -2.73 |
| Neuroendocrine: Feeling hot or cold for no reason | Improves | -2.72 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 0 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.79 |
| Neurological-Sleep: Night Sweats | Improves | -2.73 |
| Neurological-Sleep: Sleep Apnea | Worsen | 2.95 |
| Neurological-Vision: Blurred Vision | Improves | -2.61 |
| Neurological: Cognitive/Sensory Overload | Improves | -2.97 |
| Neurological: Difficulty processing information (Understanding) | Improves | -3.05 |
| Neurological: Disorientation | Improves | -2.95 |
| Neurological: emotional overload | Improves | -3.56 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 2.42 |
| Neurological: fasciculations | Improves | -2.99 |
| Neurological: High degree of Empathy before onset | Worsen | 0 |
| Neurological: Joint hypermobility | Worsen | 2.82 |
| Neurological: Short-term memory issues | Improves | -3.93 |
| Neurological: Spatial instability and disorientation | Improves | -2.95 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 1.76 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -2.53 |
| Onset: Gradual | Improves | -1.95 |
| Other: Sensitivity to mold | Worsen | 1.75 |
| Other: Sensitivity to vibrations | Improves | -2.74 |
| Pain: Eye pain | Worsen | 2.92 |
| Pain: Sensitivity to pain | Worsen | 3.4 |
| Post-exertional malaise: General | Improves | -2.61 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 0 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 0 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 0 |
| Post-exertional malaise: Rapid cognitive fatigability, | Improves | -3.05 |
| Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 0 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 0.34 |
| ADHD | Worsen | 4.05 |
| Allergies | Worsen | 3.95 |
| Alzheimer's disease | Worsen | 0 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.56 |
| Ankylosing spondylitis | Improves | -4.84 |
| Asthma | Worsen | 1.6 |
| Atherosclerosis | Improves | -5.33 |
| Autism | Worsen | 2.7 |
| Barrett esophagus cancer | Worsen | 3.01 |
| Brain Trauma | Worsen | 0 |
| Carcinoma | Improves | -2.41 |
| Celiac Disease | Worsen | 2.95 |
| Chronic Fatigue Syndrome | Improves | -3.28 |
| Chronic Kidney Disease | Worsen | 1.63 |
| Chronic urticaria (Hives) | Worsen | 1.5 |
| Colorectal Cancer | Worsen | 5.4 |
| Coronary artery disease | Improves | -2.77 |
| Crohn's Disease | Worsen | 2.99 |
| cystic fibrosis | Improves | -2.81 |
| Depression | Worsen | 3.27 |
| Epilepsy | Worsen | 2.14 |
| Fibromyalgia | Improves | -2.92 |
| Functional constipation / chronic idiopathic constipation | Worsen | 3.46 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 3.67 |
| Generalized anxiety disorder | Improves | -1.95 |
| Graves' disease | Worsen | 0 |
| Hashimoto's thyroiditis | Improves | -1.64 |
| High Blood Pressure | Improves | -3.16 |
| Histamine Issues | Improves | -4.25 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.66 |
| hypertension (High Blood Pressure | Worsen | 2.99 |
| IgA nephropathy (IgAN) | Improves | -3.96 |
| Inflammatory Bowel Disease | Improves | -4.45 |
| Insomnia | Worsen | 3.64 |
| Irritable Bowel Syndrome | Improves | -3.24 |
| Juvenile idiopathic arthritis | Worsen | 2.99 |
| Liver Cirrhosis | Improves | -5.32 |
| ME/CFS with IBS | Worsen | 1.75 |
| ME/CFS without IBS | Improves | -2.43 |
| Metabolic Syndrome | Worsen | 3.01 |
| Mood Disorders | Worsen | 0 |
| Multiple Sclerosis | Improves | -3.93 |
| Multiple system atrophy (MSA) | Improves | -3.25 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Obesity | Worsen | 4.28 |
| Osteoporosis | Improves | -2.41 |
| Parkinson's Disease | Improves | -2.83 |
| Psoriasis | Improves | -2.73 |
| Rheumatoid arthritis | Improves | -0.85 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.76 |
| Rosacea | Worsen | 2.93 |
| Schizophrenia | Worsen | 0 |
| Sjögren syndrome | Improves | -3.41 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -4.25 |
| Stress / posttraumatic stress disorder | Improves | -4.51 |
| Systemic Lupus Erythematosus | Improves | -3.72 |
| Type 1 Diabetes | Worsen | 4.13 |
| Type 2 Diabetes | Improves | -3.27 |
| Ulcerative colitis | Improves | -4.21 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.