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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 0-10	Improves	-0.46
Age: 60-70	Worsen	1.74
Asymptomatic: Minor Health Issues (a few symptoms only)	Improves	-2.5
Autism: Official Diagnosis	Worsen	1.46
Autonomic Manifestations: palpitations	Improves	-2.9
Autonomic: Inability to tolerate an upright position	Improves	-0.46
Blood Type: O Positive	Improves	-0.46
Comorbid: Constipation and Explosions (not diarrohea)	Worsen	1.74
Comorbid: High Anxiety	Worsen	1.64
Comorbid: Inflammatory bowel disease	Worsen	1.64
Comorbid: Migraine	Improves	-0.46
Comorbid: Snoring (NOT Sleep Apnea	Worsen	1.74
DePaul University Fatigue Questionnaire : Fatigue	Worsen	1.46
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Worsen	1.46
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Improves	-0.46
Immune Manifestations: Abdominal Pain	Worsen	2.48
Immune Manifestations: Inflammation (General)	Improves	-0.46
Immune Manifestations: Mucus in the stool	Improves	-0.46
Infection: Human Herpesvirus 6 (HHV6)	Worsen	1.58
Infection: Mycoplasma	Worsen	1.58
Joint: Stiffness and swelling	Worsen	1.74
Joint: Tenderness	Improves	-0.46
Neurocognitive: Slowness of thought	Worsen	2.48
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	Improves	-0.46
Neuroendocrine Manifestations: sweating episodes	Worsen	2.9
Neuroendocrine: Alcohol intolerance	Worsen	1.74
Neurological-Vision: inability to focus eye/vision	Worsen	2.61
Neurological-Vision: photophobia (Light Sensitivity)	Worsen	1.74
Neurological: Executive Decision Making (Difficulty making)	Worsen	2.42
Neurological: Impairment of concentration	Worsen	2.42
Neurological: Joint hypermobility	Worsen	2.86
Neurological: Seasonal Affective Disorder (SAD)	Worsen	1.58
Official Diagnosis: Irritable Bowel Syndrome	Worsen	1.74
Official Diagnosis: Mast Cell Dysfunction	Worsen	1.74
Pain: Sensitivity to pain	Improves	-0.46

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-2.42
Allergic Rhinitis (Hay Fever)	Improves	-2.41
Allergies	Improves	-3.14
Alzheimer's disease	Worsen	2.9
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Improves	-3.44
Ankylosing spondylitis	Worsen	3.69
Asthma	Worsen	0
Atherosclerosis	Improves	-4.71
Autism	Worsen	0.77
Bipolar Disorder	Improves	-3.34
Brain Trauma	Improves	-2.21
Carcinoma	Improves	-3.18
Celiac Disease	Improves	-2.7
Cerebral Palsy	Improves	-2.54
Chronic Fatigue Syndrome	Improves	-3.72
Chronic Kidney Disease	Improves	-3.02
Chronic Urticaria (Hives)	Improves	-3.06
Colorectal Cancer	Improves	-3.14
Coronary artery disease	Worsen	1.42
COVID-19	Improves	-3.25
Crohn's Disease	Improves	-4.92
cystic fibrosis	Improves	-2.82
Depression	Worsen	3.96
Epilepsy	Improves	-2.54
Functional constipation / chronic idiopathic constipation	Improves	-2.87
Generalized anxiety disorder	Improves	-4.13
Hashimoto's thyroiditis	Improves	-2.42
High Blood Pressure	Worsen	1.09
Histamine Issues	Improves	-4.24
IgA nephropathy (IgAN)	Improves	-1.76
Inflammatory Bowel Disease	Improves	-5.04
Irritable Bowel Syndrome	Improves	-2.39
Liver Cirrhosis	Improves	-4.73
ME/CFS with IBS	Worsen	0
ME/CFS without IBS	Improves	-2.8
Multiple Sclerosis	Improves	-3.34
Multiple system atrophy (MSA)	Worsen	0
neuropsychiatric disorders (PANDAS, PANS)	Improves	-2.42
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-3.48
Obesity	Improves	-3.99
Osteoarthritis	Improves	-2.41
Osteoporosis	Improves	-3.02
Parkinson's Disease	Worsen	3.02
Psoriasis	Improves	-2.38
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-4.61
Rosacea	Worsen	2.03
Schizophrenia	Worsen	2.45
Sjögren syndrome	Improves	-3.02
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-4.27
Stress / posttraumatic stress disorder	Improves	-4.71
Systemic Lupus Erythematosus	Improves	-3.81
Type 1 Diabetes	Improves	-3.36
Type 2 Diabetes	Improves	-4.63
Ulcerative colitis	Improves	-4.7

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.