We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Improves | -2.63 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.8 |
| Comorbid: Multiple Chemical Sensitivity | Worsen | 3.55 |
| General: Fatigue | Worsen | 2.9 |
| Immune Manifestations: Abdominal Pain | Worsen | 2.48 |
| Neurocognitive: Slowness of thought | Worsen | 2.48 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 3.55 |
| Neuroendocrine Manifestations: Muscle weakness | Worsen | 3.92 |
| Neuroendocrine: Feeling like you have a low temperature | Improves | -2.74 |
| Neuroendocrine: Lost or gained weight without trying | Worsen | 3.51 |
| Neurological: emotional overload | Improves | -2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 0 |
| Neurological: fasciculations | Improves | -2.74 |
| Neurological: High degree of Empathy before onset | Improves | -2.74 |
| Neurological: Impairment of concentration | Worsen | 0 |
| Neurological: Short-term memory issues | Improves | -2.74 |
| Neurological: Spatial instability and disorientation | Improves | -2.74 |
| Onset: less than 02 years since onset | Improves | -2.74 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Improves | -2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 2.87 |
| Allergic Rhinitis (Hay Fever) | Worsen | 0 |
| Allergies | Worsen | 2.43 |
| Alzheimer's disease | Improves | -4.19 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -0.49 |
| Ankylosing spondylitis | Worsen | 2.89 |
| Asthma | Worsen | 2.9 |
| Atherosclerosis | Improves | -2.83 |
| Autism | Worsen | 3.17 |
| Bipolar Disorder | Worsen | 0 |
| Brain Trauma | Worsen | 3.28 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Worsen | 3.73 |
| Cerebral Palsy | Improves | -2.9 |
| Chronic Kidney Disease | Worsen | 0 |
| Chronic Lyme | Worsen | 2.74 |
| Chronic Urticaria (Hives) | Worsen | 2.87 |
| Colorectal Cancer | Worsen | 2.9 |
| COVID-19 | Worsen | 2.74 |
| Crohn's Disease | Worsen | 3.4 |
| Depression | Worsen | 3.4 |
| Epilepsy | Worsen | 3.55 |
| Generalized anxiety disorder | Worsen | 0 |
| Graves' disease | Improves | -2.74 |
| High Blood Pressure | Worsen | 0 |
| Histamine Issues | Worsen | 1.36 |
| hypercholesterolemia (High Cholesterol) | Worsen | 2.87 |
| Hyperlipidemia (High Blood Fats) | Improves | -3.51 |
| IgA nephropathy (IgAN) | Worsen | 2.74 |
| Inflammatory Bowel Disease | Worsen | 3.68 |
| Irritable Bowel Syndrome | Worsen | 3.75 |
| Liver Cirrhosis | Worsen | 3.61 |
| Metabolic Syndrome | Worsen | 2.9 |
| Mood Disorders | Worsen | 2.74 |
| Multiple Sclerosis | Improves | -4.62 |
| Multiple system atrophy (MSA) | Improves | -3.55 |
| neuropsychiatric disorders (PANDAS, PANS) | Worsen | 0 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 4.12 |
| Obesity | Worsen | 4.98 |
| Osteoarthritis | Worsen | 0 |
| Osteoporosis | Worsen | 0 |
| Parkinson's Disease | Improves | -5.26 |
| Psoriasis | Improves | -3.3 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.24 |
| Schizophrenia | Improves | -3.89 |
| Sjögren syndrome | Worsen | 0 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.48 |
| Stress / posttraumatic stress disorder | Improves | -2.79 |
| Systemic Lupus Erythematosus | Worsen | 2.74 |
| Type 1 Diabetes | Worsen | 3.13 |
| Type 2 Diabetes | Worsen | 4.77 |
| Ulcerative colitis | Worsen | 4.12 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.