We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -3.64 |
| Age: 20-30 | Worsen | 2.48 |
| Age: 60-70 | Worsen | 2.91 |
| Autism: Official Diagnosis | Improves | -2.31 |
| Autonomic Manifestations: light-headedness | Improves | -1.67 |
| Blood Type: O Positive | Worsen | 3.58 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.91 |
| Comorbid-Mouth: Dry Mouth | Improves | -1.81 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 2.91 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.58 |
| Comorbid: High Anxiety | Worsen | 2.91 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 2.91 |
| Comorbid: Hypothyroidism | Worsen | 2.91 |
| Comorbid: Inflammatory bowel disease | Improves | -2.75 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -3.15 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 2.91 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.14 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.78 |
| General: Fatigue | Improves | -1.91 |
| General: Headaches | Worsen | 2.91 |
| General: Sinus issues with headaches | Worsen | 1.88 |
| Immune Manifestations: Abdominal Pain | Worsen | 2.86 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 1.88 |
| Immune Manifestations: Bloating | Worsen | 2.56 |
| Immune Manifestations: Constipation | Worsen | 1.88 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.88 |
| Infection: Mycoplasma | Improves | -2.75 |
| Joint: Stiffness and swelling | Worsen | 2.91 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 2.56 |
| Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 2.91 |
| Neurocognitive: Problems remembering things | Worsen | 2.56 |
| Neurocognitive: Slowness of thought | Worsen | 3.17 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 2.91 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -1.86 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.9 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -3.15 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.35 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 2.91 |
| Neuroendocrine: Alcohol intolerance | Worsen | 2.91 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -2.47 |
| Neurological-Audio: hypersensitivity to noise | Worsen | 2.56 |
| Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 2.56 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 2.56 |
| Neurological-Sleep: Insomnia | Worsen | 2.56 |
| Neurological-Sleep: Sleep Apnea | Improves | -1.86 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 2.91 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 2.91 |
| Neurological: Difficulty reading | Worsen | 2.91 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 3.14 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Impairment of concentration | Worsen | 2.42 |
| Neurological: Joint hypermobility | Improves | -2.75 |
| Neurological: Short-term memory issues | Worsen | 2.74 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.91 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 2.56 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 2.91 |
| Onset: 2010-2020 | Worsen | 2.91 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Pain: Sensitivity to pain | Improves | -2.75 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.64 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Daytime drowsiness | Worsen | 2.56 |
| Sleep: Problems staying asleep | Worsen | 2.56 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -4.63 |
| ADHD | Worsen | 5.16 |
| Allergic Rhinitis (Hay Fever) | Improves | -4.49 |
| Allergies | Worsen | 3 |
| Alzheimer's disease | Worsen | 4.52 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -1.63 |
| Ankylosing spondylitis | Worsen | 3.19 |
| Asthma | Improves | -3.85 |
| Atherosclerosis | Improves | -4.09 |
| Autism | Improves | -5.22 |
| Barrett esophagus cancer | Improves | -3.07 |
| Bipolar Disorder | Improves | -3.18 |
| Brain Trauma | Worsen | 3.27 |
| Carcinoma | Improves | -3 |
| Celiac Disease | Improves | -4.81 |
| Cerebral Palsy | Worsen | 1.86 |
| Chronic Fatigue Syndrome | Improves | -4.6 |
| Chronic Kidney Disease | Worsen | 1.81 |
| Chronic Lyme | Improves | -2.74 |
| Chronic Urticaria (Hives) | Improves | -4.01 |
| Colorectal Cancer | Improves | -4.34 |
| Coronary artery disease | Worsen | 0.84 |
| COVID-19 | Improves | -3.6 |
| Crohn's Disease | Improves | -3.94 |
| cystic fibrosis | Worsen | 2.39 |
| Depression | Improves | -1.66 |
| Epilepsy | Improves | -3.84 |
| Fibromyalgia | Worsen | 0.46 |
| Functional constipation / chronic idiopathic constipation | Worsen | 3.61 |
| gallstone disease (gsd) | Improves | -3.56 |
| Generalized anxiety disorder | Improves | -3.83 |
| Gout | Worsen | 3.72 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Improves | -3.33 |
| High Blood Pressure | Worsen | 0.67 |
| Histamine Issues | Worsen | 2.71 |
| hypercholesterolemia (High Cholesterol) | Improves | -2.22 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.36 |
| hypertension (High Blood Pressure | Worsen | 1.56 |
| IgA nephropathy (IgAN) | Improves | -2.97 |
| Inflammatory Bowel Disease | Improves | -4.76 |
| Irritable Bowel Syndrome | Improves | -4.32 |
| Liver Cirrhosis | Improves | -3.17 |
| ME/CFS with IBS | Improves | -3.56 |
| ME/CFS without IBS | Improves | -3.88 |
| Metabolic Syndrome | Improves | -3.26 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 5.14 |
| Multiple system atrophy (MSA) | Improves | -2.37 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -3.35 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -5.08 |
| NonCeliac Gluten Sensitivity | Improves | -2.88 |
| Obesity | Improves | -4.72 |
| Osteoarthritis | Improves | -3.34 |
| Osteoporosis | Improves | -3.82 |
| Parkinson's Disease | Worsen | 5.3 |
| Psoriasis | Improves | -2.48 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.56 |
| Rosacea | Worsen | 3.56 |
| Schizophrenia | Worsen | 4.3 |
| Sjögren syndrome | Improves | -4.31 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -4.4 |
| Stress / posttraumatic stress disorder | Improves | -4.59 |
| Systemic Lupus Erythematosus | Improves | -4.07 |
| Type 1 Diabetes | Worsen | 2.41 |
| Type 2 Diabetes | Improves | -4.56 |
| Ulcerative colitis | Improves | -5.06 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.