macrolide (antibiotics) ** full range

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Citizen Science Infered Impact

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Frequency Found	Relative Impact
Age: 20-30	Worsen	6.67
Age: 30-40	Worsen	4.03
Age: 40-50	Improves	-3.55
Age: 50-60	Worsen	5.9
Age: 60-70	Improves	-7.32
Asymptomatic: Live in house with person with probable microbiome dysfunction	Improves	-2.39
Asymptomatic: Minor Health Issues (a few symptoms only)	Improves	-7.15
Asymptomatic: No Health Issues	Worsen	6.38
Autism: Official Diagnosis	Improves	-8.29
Autonomic Manifestations: cardiac arrhythmias	Worsen	8.85
Autonomic Manifestations: Cortisol disorders or irregularity	Worsen	6.43
Autonomic Manifestations: irritable bowel syndrome	Worsen	5.77
Autonomic Manifestations: light-headedness	Improves	-6.1
Autonomic Manifestations: nausea	Improves	-7.41
Autonomic Manifestations: Orthostatic intolerance	Worsen	7.6
Autonomic Manifestations: palpitations	Worsen	6.88
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)	Improves	-7.57
Autonomic Manifestations: urinary frequency dysfunction	Worsen	8.39
Autonomic: Blurred or tunnel vision after standing	Improves	-6.81
Autonomic: Dizziness or fainting	Improves	-7.41
Autonomic: Graying or blacking out after standing	Worsen	6.28
Autonomic: Heart rate increase after standing	Worsen	6.58
Autonomic: Inability to tolerate an upright position	Improves	-9.11
Autonomic: Irregular heartbeats	Improves	-7.68
Autonomic: Nausea	Improves	-7.28
Autonomic: Ocassional Tachycardia (Rapid heart beat)	Improves	-6.54
Autonomic: Shortness of breath	Worsen	5.57
Blood Type: A Positive	Improves	-7.27
Blood Type: O Positive	Improves	-8.82
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Improves	-7.65
Comorbid-Mouth: Dry Mouth	Worsen	7.63
Comorbid-Mouth: Gingivits / Gum Disease	Improves	-5.93
Comorbid-Mouth: Mouth Sores	Worsen	5.4
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	Improves	-7.55
Comorbid: Constipation and Explosions (not diarrohea)	Improves	-8.82
Comorbid: Fibromyalgia	Worsen	7.76
Comorbid: High Anxiety	Improves	-8.79
Comorbid: Histamine or Mast Cell issues	Improves	-4.71
Comorbid: Hypothyroidism	Improves	-5.86
Comorbid: Inflammatory bowel disease	Improves	-8.75
Comorbid: Methylation issues (MTHFR)	Worsen	4.31
Comorbid: Migraine	Improves	-8.41
Comorbid: Mold Sensitivity / Exposure	Improves	-4.77
Comorbid: Multiple Chemical Sensitivity	Worsen	6.96
Comorbid: Restless Leg	Improves	-6.93
Comorbid: Snoring (NOT Sleep Apnea	Improves	-8.15
DePaul University Fatigue Questionnaire : Fatigue	Improves	-9.09
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Improves	-9.38
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Improves	-9.01
Gender: Female	Improves	-6.78
Gender: Male	Worsen	5.79
General: Depression	Worsen	4.41
General: Fatigue	Worsen	8.27
General: Headaches	Improves	-7.32
General: Heavy feeling in arms and legs	Worsen	6.72
General: Myalgia (pain)	Worsen	8.01
General: Sinus issues with headaches	Improves	-5.32
Immune Manifestations: Abdominal Pain	Improves	-7.03
Immune Manifestations: Alcohol Intolerant	Worsen	6.31
Immune Manifestations: Bloating	Worsen	5.33
Immune Manifestations: Constipation	Worsen	7.44
Immune Manifestations: Diarrhea	Worsen	6.45
Immune Manifestations: general malaise	Worsen	6.67
Immune Manifestations: Hair loss	Improves	-3.73
Immune Manifestations: Inflammation (General)	Improves	-8.69
Immune Manifestations: Inflammation of skin, eyes or joints	Worsen	6.52
Immune Manifestations: medication sensitivities.	Worsen	6.6
Immune Manifestations: Mucus in the stool	Improves	-8.14
Immune Manifestations: new food sensitivities	Worsen	7.73
Immune Manifestations: recurrent flu-like symptoms	Improves	-7.6
Immune Manifestations: tender lymph nodes	Worsen	7.8
Immune: Chronic Sinusitis	Worsen	5.21
Immune: Flu-like symptoms	Improves	-7.57
Immune: Recurrent Sore throat	Improves	-7.57
Immune: Sensitivity to smell/food/medication/chemicals	Improves	-6.7
Immune: Viral infections with prolonged recovery periods	Worsen	7.81
Infection: Epstein-Barr virus	Worsen	5.85
Infection: Human Herpesvirus 6 (HHV6)	Improves	-6.4
Infection: Lyme	Improves	-7.81
Infection: Mycoplasma	Improves	-6.85
Infection: Parasite - Other	Improves	-7.67
Joint: Redness	Improves	-7.8
Joint: Stiffness and swelling	Improves	-6.88
Joint: Sudden and severe episodes of pain	Worsen	5.52
Joint: Tenderness	Improves	-8.62
Neurocognitive: Absent-mindedness or forgetfulness	Worsen	6.09
Neurocognitive: Brain Fog	Improves	-7.49
Neurocognitive: Can only focus on one thing at a time	Improves	-5.77
Neurocognitive: Difficulty expressing thoughts	Worsen	3.51
Neurocognitive: Difficulty paying attention for a long period of time	Improves	-6.34
Neurocognitive: Difficulty understanding things	Worsen	3.42
Neurocognitive: Feeling disoriented	Improves	-7.57
Neurocognitive: Problems remembering things	Worsen	7.28
Neurocognitive: Slowness of thought	Improves	-6.8
Neurocognitive: Unable to focus vision and/or attention	Improves	-7
Neuroendocrine Manifestations: abnormal appetite	Improves	-7.37
Neuroendocrine Manifestations: Air Hunger	Worsen	6.82
Neuroendocrine Manifestations: cold extremities	Improves	-5.9
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)	Improves	-6.38
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-3.68
Neuroendocrine Manifestations: intolerance of extremes of heat and cold	Worsen	7.6
Neuroendocrine Manifestations: loss of adaptability	Improves	-6.49
Neuroendocrine Manifestations: marked weight change	Improves	-0.34
Neuroendocrine Manifestations: Muscle weakness	Worsen	7.51
Neuroendocrine Manifestations: Neuralgia	Improves	-5.13
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	Improves	-8.71
Neuroendocrine Manifestations: Rapid muscular fatiguability	Worsen	7.87
Neuroendocrine Manifestations: recurrent feelings of feverishness	Improves	-3.88
Neuroendocrine Manifestations: subnormal body temperature	Worsen	6.65
Neuroendocrine Manifestations: sweating episodes	Improves	-6.3
Neuroendocrine Manifestations: worsening of symptoms with stress.	Worsen	7.48
Neuroendocrine: Alcohol intolerance	Improves	-7.39
Neuroendocrine: Chills or shivers	Worsen	5.79
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	Worsen	4.85
Neuroendocrine: Feeling hot or cold for no reason	Worsen	6.86
Neuroendocrine: Feeling like you have a high temperature	Worsen	4.23
Neuroendocrine: Feeling like you have a low temperature	Worsen	7.5
Neuroendocrine: Lack of appetite	Worsen	8.14
Neuroendocrine: Lost or gained weight without trying	Improves	-6.45
Neuroendocrine: Sweating hands	Worsen	7.22
Neuroendocrine: Temperature fluctuations throughout the day	Improves	-3.43
Neurological-Audio: hypersensitivity to noise	Worsen	6.97
Neurological-Audio: Tinnitus (ringing in ear)	Improves	-6.56
Neurological-Sleep: Chaotic diurnal sleep rhythms (Irratic Sleep)	Worsen	6.6
Neurological-Sleep: Inability for deep (delta) sleep	Improves	-7.57
Neurological-Sleep: Insomnia	Improves	-7.06
Neurological-Sleep: Night Sweats	Worsen	3.25
Neurological-Sleep: Sleep Apnea	Worsen	5.77
Neurological-Sleep: Vivid Dreams/Nightmares	Worsen	7.6
Neurological-Vision: Blurred Vision	Worsen	8.22
Neurological-Vision: inability to focus eye/vision	Improves	-7.72
Neurological-Vision: photophobia (Light Sensitibity)	Improves	-7.76
Neurological: Cognitive Overload	Worsen	8.16
Neurological: Confusion	Worsen	7.05
Neurological: Difficulty processing information (Understanding)	Worsen	4.75
Neurological: Difficulty reading	Improves	-5.92
Neurological: Disorientation	Improves	-7.48
Neurological: Dysautonomia	Improves	-4.34
Neurological: emotional overload	Worsen	7.76
Neurological: Executive Decision Making (Difficulty making)	Improves	-6.86
Neurological: fasciculations	Worsen	7.89
Neurological: High degree of Empathy before onset	Worsen	7.6
Neurological: Impairment of concentration	Worsen	5.39
Neurological: Joint hypermobility	Improves	-6.97
Neurological: Myoclonic jerks or seizures	Improves	-5.94
Neurological: Neuropathy	Improves	-5.93
Neurological: Seasonal Affective Disorder (SAD)	Improves	-6.95
Neurological: Short-term memory issues	Worsen	7.45
Neurological: Slowed speech	Worsen	5.42
Neurological: Spatial instability and disorientation	Worsen	7.11
Neurological: Word-finding problems	Worsen	4.32
Official Diagnosis: Allergic Rhinitis (Hay Fever)	Improves	-8.6
Official Diagnosis: Autoimmune Disease	Improves	-7.92
Official Diagnosis: Chronic Fatigue Syndrome	Improves	-3.01
Official Diagnosis: Fibromyalgia	Worsen	6.55
Official Diagnosis: Irritable Bowel Syndrome	Improves	-8.49
Official Diagnosis: Mast Cell Dysfunction	Improves	-8.25
Onset: 2000-2010	Improves	-4.42
Onset: 2010-2020	Worsen	7.55
Onset: Gradual	Worsen	5.56
Onset: less than 04 years since onset	Improves	-5.93
Onset: less than 16 years since onset	Worsen	0
Other: Sensitivity to mold	Worsen	6.93
Other: Sensitivity to vibrations	Worsen	7.49
Pain: Aching of the eyes or behind the eyes	Worsen	2.41
Pain: Chest pain	Improves	-7.36
Pain: Eye pain	Improves	-7.58
Pain: Joint pain	Worsen	8.25
Pain: Myofascial pain	Improves	-4.63
Pain: Pain or aching in muscles	Worsen	7.81
Pain: Sensitivity to pain	Improves	-8.69
Post-exertional malaise: Difficulty reading after mild physical or mental activity	Worsen	7.63
Post-exertional malaise: General	Worsen	6.75
Post-exertional malaise: Inappropriate loss of physical and mental stamina,	Worsen	7.64
Post-exertional malaise: Mentally tired after the slightest effort	Improves	-6.82
Post-exertional malaise: Muscle fatigue after mild physical activity	Worsen	0
Post-exertional malaise: Next-day soreness after everyday activities	Worsen	6.63
Post-exertional malaise: Physically drained or sick after mild activity	Improves	-6.5
Post-exertional malaise: Physically tired after minimum exercise	Improves	-5.26
Post-exertional malaise: Post-exertional malaise	Worsen	6.63
Post-exertional malaise: Rapid cognitive fatigability,	Worsen	8.17
Post-exertional malaise: Rapid muscular fatigability,	Improves	-7.53
Post-exertional malaise: Worsening of symptoms after mild mental activity	Worsen	7.78
Post-exertional malaise: Worsening of symptoms after mild physical activity	Worsen	6.95
Sleep: Daytime drowsiness	Worsen	7.75
Sleep: Need to nap daily	Improves	-6.58
Sleep: Problems falling asleep	Improves	-3.74
Sleep: Problems staying asleep	Worsen	5.81
Sleep: Unrefreshed sleep	Worsen	8.12
Sleep: Waking up early in the morning (e.g. 3 AM)	Improves	-7.77

Published Science Infered Impact

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Frequency Found	Relative Impact
Acne	Worsen	5.97
ADHD	Improves	-8.22
Allergic Rhinitis (Hay Fever)	Improves	-3.24
Allergies	Worsen	7.73
Alzheimer's disease	Worsen	8.83
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	7.76
Ankylosing spondylitis	Worsen	9.22
Asthma	Worsen	5.67
Atherosclerosis	Improves	-9.6
Autism	Worsen	9.73
Autoimmune Disease	Improves	-3.29
Barrett esophagus cancer	Improves	-6.03
Brain Trauma	Improves	-6.89
Celiac Disease	Improves	-5.46
Chronic Fatigue Syndrome	Improves	-7.4
Chronic Kidney Disease	Improves	-7.56
Chronic urticaria (Hives)	Improves	-8.55
Colorectal Cancer	Improves	-10.61
Crohn's Disease	Improves	-7.57
cystic fibrosis	Improves	-7.49
Depression	Improves	-9.13
Epilepsy	Worsen	8.25
Fibromyalgia	Worsen	7.49
Functional constipation / chronic idiopathic constipation	Improves	-8.21
Gastro-esophageal reflux disease (Gerd) including Barrett's esophagus	Worsen	7.3
Generalized anxiety disorder	Improves	-8.69
Gout	Improves	-6.12
Graves' disease	Worsen	6.97
Hashimoto's thyroiditis	Improves	-7.8
High Blood Pressure	Worsen	8.63
Histamine Issues	Improves	-8.9
Histamine Issues From Ubiome	Worsen	6.01
hypercholesterolemia (High Cholesterol)	Improves	-7.01
IgA nephropathy (IgAN)	Worsen	8.52
Inflammatory Bowel Disease	Improves	-9.04
Irritable Bowel Syndrome	Improves	-9.15
Juvenile idiopathic arthritis	Worsen	5.45
Liver Cirrhosis	Worsen	5.21
ME/CFS with IBS	Improves	-8.5
ME/CFS without IBS	Improves	-9.27
Metabolic Syndrome	Worsen	7.16
Mood Disorders	Improves	-7.57
Multiple Sclerosis	Improves	-8.86
neuropsychiatric disorders (PANDAS, PANS)	Improves	-8.02
Non-alcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-6.8
Non-Celiac Gluten Sensitivity	Worsen	1.35
Obesity	Worsen	7.34
Parkinson's Disease	Improves	-8.14
Psoriasis	Improves	-9.34
Rheumatoid arthritis	Worsen	8.56
rheumatoid arthritis (RA) and Spondyloarthritis (SpA)	Improves	-8.43
Schizophrenia	Worsen	7.86
Sclerosis	Worsen	6.54
Sjögren syndrome	Improves	-8.4
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-8.71
Stress / post-traumatic stress disorder	Improves	-9.85
Systemic Lupus Erythematosus	Improves	-8.95
Type 1 Diabetes	Improves	-7.25
Type 2 Diabetes	Worsen	9.03
Ulcerative colitis	Worsen	8.57

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.