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lactobacillus helveticus and lactobacillus rhamnosus (probiotics) ** full range

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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

SymptomImpactPredictor of Bacteria Shift
Age: 20-30Worsen6.53
Age: 30-40Improves-2.07
Age: 40-50Improves-3.55
Age: 50-60Worsen7.02
Age: 60-70Worsen5.64
Asymptomatic: Live in house with person with probable microbiome dysfunctionImproves-4.19
Asymptomatic: Minor Health Issues (a few symptoms only)Improves-5.03
Asymptomatic: No Health IssuesWorsen6.09
Autism: Official DiagnosisImproves-8.09
Autonomic Manifestations: cardiac arrhythmiasWorsen8.85
Autonomic Manifestations: Cortisol disorders or irregularity Worsen6.38
Autonomic Manifestations: irritable bowel syndromeWorsen5.68
Autonomic Manifestations: light-headednessImproves-2.56
Autonomic Manifestations: Orthostatic intoleranceWorsen8.09
Autonomic Manifestations: palpitationsWorsen8.43
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)Worsen8.07
Autonomic Manifestations: urinary frequency dysfunctionWorsen8.38
Autonomic: Blurred or tunnel vision after standingWorsen5.88
Autonomic: Dizziness or faintingImproves-2.77
Autonomic: Heart rate increase after standingWorsen6.52
Autonomic: Inability to tolerate an upright positionImproves-8.5
Autonomic: Irregular heartbeatsImproves-8.46
Autonomic: Ocassional Tachycardia (Rapid heart beat)Worsen6.87
Autonomic: Shortness of breathWorsen5.79
Blood Type: A PositiveWorsen6.39
Blood Type: O PositiveImproves-9.13
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grindingImproves-7.5
Comorbid-Mouth: Dry MouthWorsen8.3
Comorbid-Mouth: Mouth SoresImproves-7.66
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndromeImproves-7.39
Comorbid: Constipation and Explosions (not diarrohea)Improves-7.64
Comorbid: FibromyalgiaWorsen7.98
Comorbid: High AnxietyImproves-8.95
Comorbid: Histamine or Mast Cell issuesImproves-6.43
Comorbid: HypothyroidismImproves-6.91
Comorbid: Inflammatory bowel disease Improves-8.45
Comorbid: Methylation issues (MTHFR)Worsen7.19
Comorbid: MigraineImproves-9.03
Comorbid: Mold Sensitivity / ExposureWorsen6.87
Comorbid: Multiple Chemical SensitivityWorsen6.27
Comorbid: Restless LegImproves-6.93
Comorbid: Snoring (NOT Sleep ApneaImproves-7.48
DePaul University Fatigue Questionnaire : FatigueImproves-8.77
DePaul University Fatigue Questionnaire : Impaired Memory & concentrationImproves-9.1
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired Improves-8.63
Gender: FemaleImproves-6.78
Gender: MaleWorsen7.9
General: DepressionImproves-7.16
General: FatigueWorsen8.13
General: HeadachesImproves-6.78
General: Heavy feeling in arms and legsWorsen6.59
General: Myalgia (pain)Worsen7.99
General: Sinus issues with headachesImproves-5.49
Immune Manifestations: Abdominal PainImproves-6.84
Immune Manifestations: Alcohol IntolerantImproves-5.42
Immune Manifestations: BloatingImproves-5.81
Immune Manifestations: ConstipationWorsen7.49
Immune Manifestations: DiarrheaWorsen6.8
Immune Manifestations: general malaiseWorsen6.14
Immune Manifestations: Hair lossImproves-4.49
Immune Manifestations: Inflammation (General)Improves-8.26
Immune Manifestations: medication sensitivities.Worsen6.6
Immune Manifestations: Mucus in the stoolImproves-7.86
Immune Manifestations: new food sensitivitiesWorsen7.67
Immune Manifestations: tender lymph nodesWorsen7.81
Immune: Chronic SinusitisWorsen5.11
Immune: Sensitivity to smell/food/medication/chemicalsWorsen5.29
Infection: Epstein-Barr virusWorsen4.87
Infection: Human Herpesvirus 6 (HHV6)Improves-5.58
Infection: LymeImproves-7.81
Infection: MycoplasmaImproves-4.18
Infection: Parasite - OtherImproves-7.74
Joint: RednessImproves-6.71
Joint: Stiffness and swellingImproves-7.67
Joint: Sudden and severe episodes of painWorsen6.28
Joint: TendernessImproves-7.77
Neurocognitive: Absent-mindedness or forgetfulnessWorsen5.83
Neurocognitive: Brain FogImproves-6.01
Neurocognitive: Can only focus on one thing at a timeImproves-6.61
Neurocognitive: Difficulty expressing thoughtsWorsen5.24
Neurocognitive: Difficulty paying attention for a long period of timeImproves-7.17
Neurocognitive: Difficulty understanding thingsWorsen3.35
Neurocognitive: Problems remembering thingsImproves-6.37
Neurocognitive: Slowness of thoughtImproves-6.55
Neurocognitive: Unable to focus vision and/or attentionImproves-7
Neuroendocrine Manifestations: Air HungerWorsen6.87
Neuroendocrine Manifestations: cold extremitiesImproves-5.49
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)Worsen3.85
Neuroendocrine Manifestations: Excessive adrenalineImproves-7.52
Neuroendocrine Manifestations: intolerance of extremes of heat and coldWorsen7.64
Neuroendocrine Manifestations: marked weight change Improves-3.48
Neuroendocrine Manifestations: Muscle weakness Worsen7.49
Neuroendocrine Manifestations: NeuralgiaImproves-5.12
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)Improves-8.51
Neuroendocrine Manifestations: Rapid muscular fatiguabilityWorsen4.43
Neuroendocrine Manifestations: recurrent feelings of feverishnessImproves-3.88
Neuroendocrine Manifestations: subnormal body temperatureWorsen6.58
Neuroendocrine Manifestations: sweating episodesWorsen6.51
Neuroendocrine Manifestations: worsening of symptoms with stress.Worsen7.02
Neuroendocrine: Alcohol intoleranceImproves-7.66
Neuroendocrine: Chills or shiversImproves-4.1
Neuroendocrine: Cold limbs (e.g. arms, legs hands)Improves-3.64
Neuroendocrine: Feeling hot or cold for no reasonWorsen6.84
Neuroendocrine: Feeling like you have a high temperatureWorsen4.23
Neuroendocrine: Feeling like you have a low temperatureWorsen7.5
Neuroendocrine: Lack of appetiteWorsen7.84
Neuroendocrine: Lost or gained weight without tryingWorsen7.57
Neuroendocrine: Sweating handsWorsen7.22
Neuroendocrine: Temperature fluctuations throughout the dayImproves-3.43
Neurological-Audio: hypersensitivity to noiseWorsen6.92
Neurological-Audio: Tinnitus (ringing in ear)Improves-6.21
Neurological-Sleep: Chaotic diurnal sleep rhythms (Irratic Sleep)Worsen5.35
Neurological-Sleep: InsomniaWorsen4.92
Neurological-Sleep: Night SweatsWorsen3.25
Neurological-Sleep: Sleep ApneaWorsen5.77
Neurological-Sleep: Vivid Dreams/NightmaresWorsen7.64
Neurological-Vision: Blurred VisionWorsen8.24
Neurological-Vision: inability to focus eye/visionImproves-6.29
Neurological-Vision: photophobia (Light Sensitibity)Improves-6.91
Neurological: Cognitive OverloadWorsen6.96
Neurological: ConfusionWorsen7.63
Neurological: Difficulty processing information (Understanding)Improves-5.95
Neurological: Difficulty readingWorsen4.51
Neurological: DisorientationWorsen5.39
Neurological: DysautonomiaWorsen1.57
Neurological: emotional overloadWorsen7.76
Neurological: Executive Decision Making (Difficulty making)Improves-7.24
Neurological: fasciculations Worsen7.89
Neurological: High degree of Empathy before onsetWorsen7.52
Neurological: Impairment of concentrationImproves-4.9
Neurological: Joint hypermobilityImproves-7.45
Neurological: Myoclonic jerks or seizures Improves-5.94
Neurological: Seasonal Affective Disorder (SAD)Improves-7.98
Neurological: Short-term memory issuesWorsen7.76
Neurological: Spatial instability and disorientationWorsen7.66
Neurological: Word-finding problemsWorsen4.46
Official Diagnosis: Allergic Rhinitis (Hay Fever)Improves-8.8
Official Diagnosis: Autoimmune DiseaseImproves-5.24
Official Diagnosis: Chronic Fatigue SyndromeImproves-4.74
Official Diagnosis: Irritable Bowel SyndromeImproves-8.05
Official Diagnosis: Mast Cell DysfunctionImproves-8.13
Onset: 2000-2010Worsen4.81
Onset: 2010-2020Worsen7.13
Onset: GradualWorsen6.38
Onset: less than 02 years since onsetWorsen7.86
Onset: less than 16 years since onsetImproves-2.96
Other: Sensitivity to moldWorsen7.67
Pain: Chest painImproves-7.16
Pain: Eye painImproves-6.54
Pain: Joint painImproves-6.47
Pain: Myofascial painImproves-4.87
Pain: Pain or aching in musclesWorsen7.8
Pain: Sensitivity to painImproves-8.15
Post-exertional malaise: Difficulty reading after mild physical or mental activityWorsen4.16
Post-exertional malaise: GeneralWorsen6.77
Post-exertional malaise: Inappropriate loss of physical and mental stamina,Improves-5.28
Post-exertional malaise: Mentally tired after the slightest effortImproves-6.4
Post-exertional malaise: Muscle fatigue after mild physical activityImproves-6.94
Post-exertional malaise: Next-day soreness after everyday activitiesImproves-5.64
Post-exertional malaise: Physically drained or sick after mild activityWorsen7.28
Post-exertional malaise: Physically tired after minimum exerciseImproves-6.5
Post-exertional malaise: Rapid cognitive fatigability, Worsen8.16
Post-exertional malaise: Rapid muscular fatigability, Improves-3.59
Post-exertional malaise: Worsening of symptoms after mild mental activityWorsen7.47
Post-exertional malaise: Worsening of symptoms after mild physical activityWorsen6.6
Sleep: Daytime drowsinessWorsen7.73
Sleep: Need to nap dailyImproves-6.58
Sleep: Problems falling asleepWorsen7.77
Sleep: Problems staying asleepWorsen7.16
Sleep: Unrefreshed sleepWorsen7.99
Sleep: Waking up early in the morning (e.g. 3 AM)Improves-6.57

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

SymptomImpactPredictor of Bacteria Shift
Allergic Rhinitis (Hay Fever)Improves-3.24
Alzheimer's diseaseWorsen8.83
Amyotrophic lateral sclerosis (ALS) Motor NeuronWorsen7.76
Ankylosing spondylitisWorsen9.22
Autoimmune DiseaseImproves-3.29
Barrett esophagus cancerImproves-6.03
Brain TraumaImproves-6.89
Celiac DiseaseImproves-5.4
Chronic Fatigue SyndromeImproves-7.4
Chronic Kidney DiseaseImproves-7.56
Chronic urticaria (Hives)Improves-8.55
Colorectal CancerImproves-10.61
Crohn's DiseaseImproves-9.75
cystic fibrosisImproves-7.49
Functional constipation / chronic idiopathic constipationImproves-8.21
Gastro-esophageal reflux disease (Gerd) including Barrett's esophagusWorsen7.3
Generalized anxiety disorderImproves-8.69
Graves' diseaseWorsen6.97
Hashimoto's thyroiditisImproves-7.8
High Blood PressureWorsen8.63
Histamine IssuesImproves-8.9
Histamine Issues From UbiomeWorsen6.01
hypercholesterolemia (High Cholesterol)Improves-7.01
IgA nephropathy (IgAN)Worsen8.52
Inflammatory Bowel DiseaseImproves-9.07
Irritable Bowel SyndromeImproves-9.4
Juvenile idiopathic arthritisWorsen5.45
Liver CirrhosisImproves-9.14
ME/CFS with IBSImproves-8.5
ME/CFS without IBSImproves-9.27
Metabolic SyndromeWorsen7.16
Mood DisordersImproves-7.57
Multiple SclerosisImproves-8.86
neuropsychiatric disorders (PANDAS, PANS)Improves-8.02
Non-alcoholic Fatty Liver Disease (nafld) NonalcoholicImproves-6.8
Non-Celiac Gluten SensitivityWorsen1.35
Parkinson's DiseaseImproves-8.14
Rheumatoid arthritisWorsen8.15
rheumatoid arthritis (RA) and Spondyloarthritis (SpA)Improves-8.43
Sjögren syndromeImproves-8.4
Small Intestinal Bacterial Overgrowth (SIBO)Improves-9.08
Stress / post-traumatic stress disorderImproves-9.85
Systemic Lupus ErythematosusImproves-8.95
Type 1 DiabetesImproves-7.25
Type 2 DiabetesImproves-8.21
Ulcerative colitisWorsen8.38

Bacteria Impacted

Suggest a missed study:

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

📓 - direct citation | 👪 - Impacts Parent Taxa | 👶 - Impacts Child Taxa | 🧙 - Inferred
Taxonomy Rank Effect Citations
Enterobacteriaceae family Decreases 📓 Source Study
Levinea Young et al. 1971 genus Decreases 📓 Source Study
Atlantibacter genus Decreases 👪 Source Study
Biostraticola genus Decreases 👪 Source Study
Buttiauxella genus Decreases 👪 Source Study
Candidatus Ishikawaella genus Decreases 👪 Source Study
Cedecea genus Decreases 👪 Source Study
Gibbsiella genus Decreases 👪 Source Study
Kosakonia genus Decreases 👪 Source Study
Leclercia genus Decreases 👪 Source Study
Lelliottia genus Decreases 👪 Source Study
Limnobaculum genus Decreases 👪 Source Study
Metakosakonia genus Decreases 👪 Source Study
Moranella genus Decreases 👪 Source Study
Pluralibacter genus Decreases 👪 Source Study
Pseudescherichia genus Decreases 👪 Source Study
Raoultella genus Decreases 👪 Source Study
Riesia genus Decreases 👪 Source Study
Rosenbergiella genus Decreases 👪 Source Study
Shimwellia genus Decreases 👪 Source Study
Siccibacter genus Decreases 👪 Source Study
Yokenella genus Decreases 👪 Source Study
ATCC 51112 species Decreases 👪 Source Study
Citrobacter amalonaticus species Decreases 👪 Source Study
Citrobacter sp. species Decreases 👪 Source Study
Citrobacter sp. BW4 species Decreases 👪 Source Study
Citrobacter sp. HD4.9 species Decreases 👪 Source Study
JCM 1658 species Decreases 👪 Source Study

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