licorice ** full range

Check for interactions on Supp.AI

Sources

Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 0-10	Improves	-4.33
Age: 20-30	Worsen	2.76
Age: 50-60	Worsen	2.78
Age: 60-70	Worsen	3.78
Asymptomatic: Live in house with person with probable microbiome dysfunction	Improves	-3.07
Asymptomatic: Minor Health Issues (a few symptoms only)	Worsen	2.09
Asymptomatic: No Health Issues	Improves	-3.27
Autism: Official Diagnosis	Improves	-2.96
Autonomic Manifestations: cardiac arrhythmias	Improves	-2.89
Autonomic Manifestations: Cortisol disorders or irregularity	Improves	-4
Autonomic Manifestations: irritable bowel syndrome	Improves	-3.67
Autonomic Manifestations: light-headedness	Improves	-1.67
Autonomic Manifestations: Orthostatic intolerance	Improves	-3.28
Autonomic Manifestations: palpitations	Improves	-3.82
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)	Improves	-2.73
Autonomic Manifestations: urinary frequency dysfunction	Worsen	2.78
Autonomic: Blurred or tunnel vision after standing	Improves	-3.54
Autonomic: Graying or blacking out after standing	Improves	-2.92
Autonomic: Heart rate increase after standing	Improves	-3.05
Autonomic: Inability to tolerate an upright position	Improves	-3.91
Autonomic: Irregular heartbeats	Improves	-3.77
Autonomic: Shortness of breath	Improves	-2.88
Blood Type: A Positive	Improves	-3.57
Blood Type: O Positive	Worsen	1.14
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Worsen	3.28
Comorbid-Mouth: Dry Mouth	Worsen	3.08
Comorbid-Mouth: Mouth Sores	Improves	-1.38
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	Improves	-4.55
Comorbid: Constipation and Diarrohea (not explosions)	Improves	-2.77
Comorbid: Constipation and Explosions (not diarrohea)	Improves	-4.55
Comorbid: Fibromyalgia	Worsen	1.02
Comorbid: High Anxiety	Improves	-3.92
Comorbid: Histamine or Mast Cell issues	Improves	-1.47
Comorbid: Hypothyroidism	Improves	-3.92
Comorbid: Inflammatory bowel disease	Improves	-2.88
Comorbid: Methylation issues (MTHFR)	Improves	-3.01
Comorbid: Migraine	Worsen	1.33
Comorbid: Mold Sensitivity / Exposure	Improves	-2.43
Comorbid: Multiple Chemical Sensitivity	Improves	-1.53
Comorbid: Snoring (NOT Sleep Apnea	Improves	-4.05
DePaul University Fatigue Questionnaire : Abdomen pain	Worsen	2.81
DePaul University Fatigue Questionnaire : Allergies	Worsen	1.55
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	1.99
DePaul University Fatigue Questionnaire : Depression	Worsen	2.71
DePaul University Fatigue Questionnaire : Difficulty falling asleep	Worsen	3.83
DePaul University Fatigue Questionnaire : Difficulty finding the right word	Improves	-1.16
DePaul University Fatigue Questionnaire : Difficulty staying asleep	Worsen	3.49
DePaul University Fatigue Questionnaire : Fatigue	Worsen	4.06
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	3.83
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Worsen	2.06
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Worsen	2.08
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	3.53
Gender: Female	Worsen	2.92
General: Depression	Worsen	1.71
General: Fatigue	Worsen	2.9
General: Headaches	Worsen	2.42
General: Myalgia (pain)	Improves	-3.83
General: Sinus issues with headaches	Worsen	3.25
Immune Manifestations: Abdominal Pain	Improves	-3.7
Immune Manifestations: Alcohol Intolerant	Improves	-3.72
Immune Manifestations: Bloating	Improves	-2.3
Immune Manifestations: Constipation	Improves	-2.1
Immune Manifestations: Diarrhea	Worsen	3.92
Immune Manifestations: general malaise	Improves	-3.45
Immune Manifestations: Hair loss	Improves	-2.58
Immune Manifestations: Inflammation (General)	Improves	-2.23
Immune Manifestations: medication sensitivities.	Improves	-3.05
Immune Manifestations: Mucus in the stool	Improves	-3.83
Immune Manifestations: new food sensitivities	Worsen	3.3
Immune: Recurrent Sore throat	Worsen	0.33
Immune: Sensitivity to smell/food/medication/chemicals	Improves	-3.12
Infection: Epstein-Barr virus	Worsen	2.44
Infection: Human Herpesvirus 6 (HHV6)	Improves	-2.46
Infection: Mycoplasma	Improves	-3.08
Infection: Parasite - Other	Improves	-3.56
Joint: Stiffness and swelling	Worsen	1.42
Joint: Tenderness	Improves	-3.6
Neurocognitive: Brain Fog	Improves	-2.96
Neurocognitive: Can only focus on one thing at a time	Improves	-2.09
Neurocognitive: Difficulty paying attention for a long period of time	Improves	-3.39
Neurocognitive: Difficulty understanding things	Improves	-2.33
Neurocognitive: Problems remembering things	Improves	-2.91
Neurocognitive: Slowness of thought	Improves	-3.12
Neurocognitive: Unable to focus vision and/or attention	Improves	-3
Neuroendocrine Manifestations: Air Hunger	Improves	-3.43
Neuroendocrine Manifestations: cold extremities	Improves	-3.54
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)	Improves	-3.36
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-2.61
Neuroendocrine Manifestations: intolerance of extremes of heat and cold	Worsen	3.59
Neuroendocrine Manifestations: loss of adaptability	Worsen	2.84
Neuroendocrine Manifestations: Muscle weakness	Worsen	3.59
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	Improves	-3.88
Neuroendocrine Manifestations: Rapid muscular fatiguability	Improves	-2.73
Neuroendocrine Manifestations: subnormal body temperature	Improves	-4.44
Neuroendocrine Manifestations: sweating episodes	Improves	-3.49
Neuroendocrine Manifestations: worsening of symptoms with stress.	Improves	-3.28
Neuroendocrine: Alcohol intolerance	Improves	-0.01
Neuroendocrine: Chills or shivers	Worsen	3.4
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	Worsen	1.71
Neuroendocrine: Feeling hot or cold for no reason	Worsen	3.85
Neuroendocrine: Feeling like you have a high temperature	Worsen	3.29
Neuroendocrine: Lack of appetite	Worsen	3.02
Neuroendocrine: Lost or gained weight without trying	Worsen	2.9
Neurological-Audio: hypersensitivity to noise	Improves	-3.92
Neurological-Audio: Tinnitus (ringing in ear)	Improves	-2.84
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Worsen	2.29
Neurological-Sleep: Insomnia	Improves	-2.28
Neurological-Sleep: Night Sweats	Improves	-3.19
Neurological-Sleep: Sleep Apnea	Worsen	3.48
Neurological-Sleep: Vivid Dreams/Nightmares	Improves	-2.08
Neurological-Vision: Blurred Vision	Improves	-2.92
Neurological-Vision: inability to focus eye/vision	Improves	-3.8
Neurological-Vision: photophobia (Light Sensitivity)	Worsen	2.36
Neurological: Cognitive/Sensory Overload	Improves	-2.73
Neurological: Difficulty processing information (Understanding)	Improves	-2.17
Neurological: Difficulty reading	Worsen	3.61
Neurological: Disorientation	Worsen	2.96
Neurological: Dysautonomia	Worsen	2.42
Neurological: emotional overload	Improves	-2.73
Neurological: Executive Decision Making (Difficulty making)	Improves	-3.35
Neurological: fasciculations	Improves	-2.92
Neurological: Impairment of concentration	Improves	-1.38
Neurological: Joint hypermobility	Improves	-4.45
Neurological: Neuropathy	Worsen	2.96
Neurological: Seasonal Affective Disorder (SAD)	Worsen	0.4
Neurological: Short-term memory issues	Worsen	0.74
Neurological: Slowed speech	Worsen	2.84
Neurological: Spatial instability and disorientation	Worsen	2.95
Official Diagnosis: Allergic Rhinitis (Hay Fever)	Improves	-4.5
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD)	Worsen	2.84
Official Diagnosis: Autoimmune Disease	Worsen	2.65
Official Diagnosis: Irritable Bowel Syndrome	Improves	-1.5
Official Diagnosis: Mast Cell Dysfunction	Improves	-4
Onset: 2010-2020	Improves	-3.28
Onset: Gradual	Improves	-2.91
Other: Sensitivity to mold	Improves	-2.73
Pain: Aching of the eyes or behind the eyes	Improves	-2.73
Pain: Myofascial pain	Improves	-2.73
Pain: Pain or aching in muscles	Worsen	2.71
Pain: Sensitivity to pain	Improves	-3.9
Post-exertional malaise: Difficulty reading after mild physical or mental activity	Improves	-4.41
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	2.88
Post-exertional malaise: Physically drained or sick after mild activity	Improves	-3.12
Post-exertional malaise: Rapid cognitive fatigability,	Improves	-3.68
Sleep: Daytime drowsiness	Improves	-2.96
Sleep: Problems staying asleep	Worsen	3.8
Sleep: Waking up early in the morning (e.g. 3 AM)	Worsen	2.35

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-3.9
ADHD	Worsen	5.87
Allergic Rhinitis (Hay Fever)	Worsen	2.72
Allergies	Worsen	4.54
Alzheimer's disease	Worsen	4.5
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Improves	-3.2
Ankylosing spondylitis	Worsen	5.06
Asthma	Worsen	3.86
Atherosclerosis	Improves	-5.38
Autism	Worsen	5.86
Barrett esophagus cancer	Improves	-2.1
Bipolar Disorder	Improves	-2.42
Brain Trauma	Worsen	4.77
Carcinoma	Improves	-4.03
Celiac Disease	Worsen	5.13
Cerebral Palsy	Worsen	3.88
Chronic Fatigue Syndrome	Improves	-3.91
Chronic Kidney Disease	Worsen	3.17
Chronic Lyme	Worsen	3.01
Chronic Urticaria (Hives)	Worsen	4.71
Colorectal Cancer	Worsen	4.83
Coronary artery disease	Improves	-2.02
COVID-19	Improves	-1.72
Crohn's Disease	Improves	-4.28
cystic fibrosis	Improves	-2.24
Depression	Worsen	4.31
Epilepsy	Improves	-4.22
Fibromyalgia	Improves	-3.96
Functional constipation / chronic idiopathic constipation	Worsen	4.32
gallstone disease (gsd)	Improves	-0.82
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Worsen	3.6
Generalized anxiety disorder	Improves	-4.28
Gout	Worsen	3.8
Graves' disease	Improves	-2.76
Hashimoto's thyroiditis	Improves	-4.87
High Blood Pressure	Worsen	4.79
Histamine Issues	Improves	-3.68
Histamine Issues From Ubiome	Worsen	2.72
hypercholesterolemia (High Cholesterol)	Worsen	3.02
Hyperlipidemia (High Blood Fats)	Worsen	3.52
hypertension (High Blood Pressure	Worsen	2.39
IgA nephropathy (IgAN)	Worsen	3.93
Inflammatory Bowel Disease	Worsen	5.27
Insomnia	Worsen	3.05
Irritable Bowel Syndrome	Improves	-5.19
Liver Cirrhosis	Worsen	4.5
ME/CFS with IBS	Worsen	3.34
ME/CFS without IBS	Improves	-4.02
Metabolic Syndrome	Worsen	2.9
Mood Disorders	Improves	-3.57
Multiple Sclerosis	Improves	-3.28
Multiple system atrophy (MSA)	Worsen	2.66
neuropsychiatric disorders (PANDAS, PANS)	Worsen	2.59
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Worsen	4.39
NonCeliac Gluten Sensitivity	Improves	-2.88
Obesity	Worsen	4.95
Osteoarthritis	Improves	-3.21
Osteoporosis	Improves	-3.76
Parkinson's Disease	Worsen	5.49
Psoriasis	Improves	-2.67
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-5.38
Rosacea	Worsen	2.94
Schizophrenia	Improves	-2.92
Sjögren syndrome	Improves	-4.87
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-3.98
Stress / posttraumatic stress disorder	Improves	-4.81
Systemic Lupus Erythematosus	Improves	-4.22
Type 1 Diabetes	Worsen	4.54
Type 2 Diabetes	Worsen	5.76
Ulcerative colitis	Improves	-4.68

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.