We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -2.75 |
| Age: 20-30 | Improves | -2.76 |
| Age: 50-60 | Worsen | 1.51 |
| Age: 60-70 | Improves | -3 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.82 |
| Asymptomatic: No Health Issues | Worsen | 1.36 |
| Autism: Official Diagnosis | Worsen | 3.33 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -1.7 |
| Autonomic Manifestations: irritable bowel syndrome | Worsen | 3.03 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -3.59 |
| Autonomic Manifestations: palpitations | Improves | -2.93 |
| Autonomic: Inability to tolerate an upright position | Improves | -3.45 |
| Autonomic: Irregular heartbeats | Worsen | 1.19 |
| Autonomic: Shortness of breath | Improves | -2.86 |
| Blood Type: A Positive | Improves | -1.88 |
| Blood Type: O Positive | Improves | -0.58 |
| Comorbid-Mouth: Dry Mouth | Improves | -1.76 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 2.79 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -2.31 |
| Comorbid: Fibromyalgia | Improves | -2.92 |
| Comorbid: High Anxiety | Improves | -2.31 |
| Comorbid: Histamine or Mast Cell issues | Improves | -1.7 |
| Comorbid: Inflammatory bowel disease | Improves | -3.3 |
| Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
| Comorbid: Migraine | Worsen | 1.86 |
| Comorbid: Multiple Chemical Sensitivity | Worsen | 3.03 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.44 |
| Condition: ME/CFS with IBS | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 1.98 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.67 |
| DePaul University Fatigue Questionnaire : Depression | Worsen | 3.54 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.07 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.54 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.17 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 2.59 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.6 |
| General: Headaches | Improves | -1.62 |
| General: Myalgia (pain) | Worsen | 3.03 |
| General: Sinus issues with headaches | Worsen | 1.36 |
| Immune Manifestations: Alcohol Intolerant | Improves | -1.62 |
| Immune Manifestations: general malaise | Worsen | 3.03 |
| Immune Manifestations: Inflammation (General) | Worsen | 3.24 |
| Immune Manifestations: Mucus in the stool | Improves | -2.92 |
| Immune: Sensitivity to smell/food/medication/chemicals | Worsen | 3.03 |
| Infection: Human Herpesvirus 6 (HHV6) | Improves | -1.04 |
| Infection: Mycoplasma | Improves | -2.92 |
| Infection: Parasite - Other | Worsen | 3.01 |
| Joint: Redness | Improves | -2.82 |
| Joint: Stiffness and swelling | Improves | -3.13 |
| Joint: Tenderness | Worsen | 2.14 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 3.03 |
| Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 3.03 |
| Neurocognitive: Slowness of thought | Worsen | 3.03 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.01 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 2.63 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -2.75 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 3.03 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 3.03 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.03 |
| Neuroendocrine: Alcohol intolerance | Improves | -3.13 |
| Neuroendocrine: Feeling like you have a low temperature | Improves | -3.11 |
| Neuroendocrine: Lack of appetite | Worsen | 3.03 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -1.79 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.12 |
| Neurological-Sleep: Insomnia | Improves | -2.92 |
| Neurological-Vision: Blurred Vision | Improves | -2.93 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.92 |
| Neurological-Vision: photophobia (Light Sensitivity) | Improves | -2.92 |
| Neurological: Confusion | Improves | -2.97 |
| Neurological: Difficulty reading | Improves | -2.92 |
| Neurological: fasciculations | Improves | -3.16 |
| Neurological: Impairment of concentration | Worsen | 3.03 |
| Neurological: Joint hypermobility | Improves | -2.82 |
| Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.36 |
| Neurological: Short-term memory issues | Improves | -1.56 |
| Neurological: Slowed speech | Improves | -2.99 |
| Neurological: Word-finding problems | Improves | -1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.24 |
| Official Diagnosis: Autoimmune Disease | Worsen | 1.6 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.92 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -2.8 |
| Onset: Gradual | Worsen | 3.03 |
| Other: Sensitivity to mold | Improves | -1.76 |
| Pain: Sensitivity to pain | Improves | -2.82 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.69 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.56 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 3.03 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 3.03 |
| Sleep: Problems staying asleep | Improves | -3.3 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -3.13 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -3.94 |
| ADHD | Worsen | 3.65 |
| Allergic Rhinitis (Hay Fever) | Worsen | 2.46 |
| Allergies | Improves | -4.53 |
| Alzheimer's disease | Improves | -3.57 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.9 |
| Ankylosing spondylitis | Worsen | 3.42 |
| Asthma | Worsen | 2.93 |
| Atherosclerosis | Improves | -3.86 |
| Autism | Improves | -5.29 |
| Barrett esophagus cancer | Worsen | 3.1 |
| Bipolar Disorder | Worsen | 3.09 |
| Brain Trauma | Improves | -4.45 |
| Carcinoma | Worsen | 2.76 |
| Celiac Disease | Improves | -4.39 |
| Cerebral Palsy | Worsen | 3.31 |
| Chronic Fatigue Syndrome | Improves | -4.19 |
| Chronic Kidney Disease | Improves | -2.84 |
| Chronic Lyme | Improves | -3.01 |
| Chronic Urticaria (Hives) | Improves | -3.74 |
| Colorectal Cancer | Worsen | 4.56 |
| Coronary artery disease | Improves | -1.47 |
| COVID-19 | Improves | -3.21 |
| Crohn's Disease | Worsen | 2.23 |
| Depression | Worsen | 4.73 |
| Epilepsy | Improves | -3.56 |
| Fibromyalgia | Improves | -4.78 |
| Functional constipation / chronic idiopathic constipation | Improves | -3.96 |
| gallstone disease (gsd) | Improves | -3.09 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
| Generalized anxiety disorder | Worsen | 2.71 |
| Graves' disease | Worsen | 3.48 |
| Hashimoto's thyroiditis | Improves | -3.13 |
| High Blood Pressure | Improves | -4.14 |
| Histamine Issues | Worsen | 2.89 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| hypercholesterolemia (High Cholesterol) | Worsen | 2.76 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.63 |
| IgA nephropathy (IgAN) | Improves | -4.24 |
| Inflammatory Bowel Disease | Improves | -5.26 |
| Insomnia | Improves | -3.56 |
| Irritable Bowel Syndrome | Improves | -3.55 |
| Liver Cirrhosis | Improves | -4.16 |
| ME/CFS with IBS | Improves | -3.02 |
| ME/CFS without IBS | Worsen | 3.72 |
| Multiple Sclerosis | Improves | -5.31 |
| Multiple system atrophy (MSA) | Improves | -1.3 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.89 |
| NonCeliac Gluten Sensitivity | Improves | -2.88 |
| Obesity | Worsen | 4.13 |
| Osteoarthritis | Worsen | 2.9 |
| Osteoporosis | Worsen | 3.81 |
| Parkinson's Disease | Worsen | 3.67 |
| Psoriasis | Worsen | 4.22 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.77 |
| Rosacea | Improves | -3.37 |
| Schizophrenia | Worsen | 0.02 |
| Sjögren syndrome | Improves | -1.48 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 3.31 |
| Stress / posttraumatic stress disorder | Worsen | 4.44 |
| Systemic Lupus Erythematosus | Worsen | 2.22 |
| Type 1 Diabetes | Improves | -4.56 |
| Type 2 Diabetes | Improves | -3.79 |
| Ulcerative colitis | Improves | -4.57 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.