We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 20-30 | Worsen | 3.13 |
Age: 30-40 | Worsen | 1.79 |
Age: 50-60 | Improves | -1.51 |
Age: 60-70 | Worsen | 3.14 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -2.43 |
Asymptomatic: No Health Issues | Improves | -1.78 |
Autism: Official Diagnosis | Improves | -4.12 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 3.94 |
Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 3.05 |
Autonomic Manifestations: irritable bowel syndrome | Worsen | 1.71 |
Autonomic Manifestations: Orthostatic intolerance | Worsen | 4.04 |
Autonomic Manifestations: palpitations | Worsen | 4.08 |
Autonomic: Blurred or tunnel vision after standing | Improves | -2.83 |
Autonomic: Dizziness or fainting | Worsen | 1.52 |
Autonomic: Graying or blacking out after standing | Worsen | 2.92 |
Autonomic: Heart rate increase after standing | Worsen | 3.2 |
Autonomic: Inability to tolerate an upright position | Improves | -3.76 |
Autonomic: Irregular heartbeats | Improves | -1.31 |
Autonomic: Ocassional Tachycardia (Rapid heart beat) | Worsen | 2.7 |
Autonomic: Shortness of breath | Worsen | 2.57 |
Blood Type: A Positive | Worsen | 1.28 |
Blood Type: O Positive | Improves | -3.91 |
Comorbid-Mouth: Dry Mouth | Worsen | 2.99 |
Comorbid-Mouth: Mouth Sores | Worsen | 1.84 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -3.77 |
Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.94 |
Comorbid: Fibromyalgia | Worsen | 3.15 |
Comorbid: High Anxiety | Improves | -4.17 |
Comorbid: Histamine or Mast Cell issues | Improves | -4.08 |
Comorbid: Hypothyroidism | Improves | -3.65 |
Comorbid: Inflammatory bowel disease | Improves | -3.51 |
Comorbid: Migraine | Improves | -3.39 |
Comorbid: Mold Sensitivity / Exposure | Worsen | 3.05 |
Comorbid: Multiple Chemical Sensitivity | Improves | -2.75 |
Comorbid: Restless Leg | Improves | -2.63 |
Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.71 |
Condition: ME/CFS with IBS | Improves | -3.01 |
DePaul University Fatigue Questionnaire : Allergies | Improves | -4.54 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Improves | -3.23 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Improves | -3.97 |
DePaul University Fatigue Questionnaire : Fatigue | Improves | -5.17 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Improves | -2.97 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -5.06 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -4.63 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -3.99 |
Gender: Female | Worsen | 2.83 |
General: Depression | Worsen | 1.71 |
General: Fatigue | Worsen | 3.12 |
General: Headaches | Worsen | 1.62 |
General: Heavy feeling in arms and legs | Worsen | 2.88 |
General: Myalgia (pain) | Worsen | 3.35 |
General: Sinus issues with headaches | Improves | -3.75 |
Immune Manifestations: Abdominal Pain | Improves | -3.61 |
Immune Manifestations: Alcohol Intolerant | Improves | -2.83 |
Immune Manifestations: Bloating | Worsen | 3.1 |
Immune Manifestations: Constipation | Worsen | 1.84 |
Immune Manifestations: Diarrhea | Worsen | 3.13 |
Immune Manifestations: general malaise | Worsen | 3.1 |
Immune Manifestations: Hair loss | Improves | -1.9 |
Immune Manifestations: Inflammation (General) | Improves | -4.24 |
Immune Manifestations: medication sensitivities. | Worsen | 3.05 |
Immune Manifestations: Mucus in the stool | Improves | -4.13 |
Immune Manifestations: new food sensitivities | Worsen | 3.54 |
Immune Manifestations: tender lymph nodes | Worsen | 2.52 |
Immune: Sensitivity to smell/food/medication/chemicals | Worsen | 1.64 |
Infection: Epstein-Barr virus | Improves | -2.87 |
Infection: Human Herpesvirus 6 (HHV6) | Improves | -3.45 |
Infection: Mycoplasma | Improves | -2.5 |
Infection: Parasite - Other | Improves | -3.49 |
Joint: Redness | Worsen | 2.82 |
Joint: Stiffness and swelling | Worsen | 2.44 |
Joint: Sudden and severe episodes of pain | Worsen | 1.85 |
Joint: Tenderness | Improves | -3.28 |
Neurocognitive: Can only focus on one thing at a time | Improves | -2.83 |
Neurocognitive: Difficulty paying attention for a long period of time | Improves | -2.83 |
Neurocognitive: Problems remembering things | Improves | -2.83 |
Neurocognitive: Slowness of thought | Improves | -2.83 |
Neurocognitive: Unable to focus vision and/or attention | Improves | -3.49 |
Neuroendocrine Manifestations: Air Hunger | Worsen | 2.91 |
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Worsen | 2.89 |
Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 2.1 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.36 |
Neuroendocrine Manifestations: Muscle weakness | Improves | -1.91 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -4.1 |
Neuroendocrine Manifestations: subnormal body temperature | Improves | -2.93 |
Neuroendocrine Manifestations: sweating episodes | Worsen | 1.71 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.45 |
Neuroendocrine: Alcohol intolerance | Improves | -3.95 |
Neuroendocrine: Chills or shivers | Worsen | 3.36 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 3.24 |
Neuroendocrine: Feeling hot or cold for no reason | Worsen | 3.36 |
Neuroendocrine: Feeling like you have a high temperature | Worsen | 2.08 |
Neuroendocrine: Feeling like you have a low temperature | Worsen | 0 |
Neuroendocrine: Lack of appetite | Worsen | 4.19 |
Neuroendocrine: Lost or gained weight without trying | Worsen | 2.5 |
Neuroendocrine: Sweating hands | Worsen | 2.85 |
Neurological-Audio: hypersensitivity to noise | Worsen | 0.58 |
Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 1.25 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 2.51 |
Neurological-Sleep: Insomnia | Worsen | 2.55 |
Neurological-Sleep: Night Sweats | Worsen | 1.71 |
Neurological-Sleep: Sleep Apnea | Worsen | 1.97 |
Neurological-Vision: Blurred Vision | Worsen | 3.59 |
Neurological-Vision: inability to focus eye/vision | Improves | -3.44 |
Neurological-Vision: photophobia (Light Sensitivity) | Improves | -3.59 |
Neurological: Cognitive/Sensory Overload | Worsen | 3.1 |
Neurological: Difficulty processing information (Understanding) | Worsen | 3.42 |
Neurological: Difficulty reading | Improves | -2.6 |
Neurological: emotional overload | Worsen | 3.05 |
Neurological: Executive Decision Making (Difficulty making) | Improves | -2.52 |
Neurological: fasciculations | Worsen | 3.12 |
Neurological: High degree of Empathy before onset | Worsen | 0 |
Neurological: Impairment of concentration | Worsen | 3.38 |
Neurological: Joint hypermobility | Improves | -2.87 |
Neurological: Seasonal Affective Disorder (SAD) | Improves | -1.49 |
Neurological: Short-term memory issues | Worsen | 3.21 |
Neurological: Slowed speech | Worsen | 1.61 |
Neurological: Spatial instability and disorientation | Worsen | 0 |
Neurological: Word-finding problems | Worsen | 1.79 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -4.46 |
Official Diagnosis: Autoimmune Disease | Improves | -2.29 |
Official Diagnosis: Chronic Fatigue Syndrome | Worsen | 2.08 |
Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.46 |
Official Diagnosis: Mast Cell Dysfunction | Improves | -3.43 |
Onset: 2010-2020 | Worsen | 0.58 |
Onset: Gradual | Worsen | 2.43 |
Other: Sensitivity to mold | Worsen | 2.3 |
Pain: Aching of the eyes or behind the eyes | Worsen | 1.49 |
Pain: Chest pain | Improves | -2.96 |
Pain: Eye pain | Improves | -2.92 |
Pain: Joint pain | Worsen | 2.83 |
Pain: Myofascial pain | Worsen | 1.49 |
Pain: Sensitivity to pain | Improves | -2.56 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Improves | -3.51 |
Post-exertional malaise: General | Worsen | 0 |
Post-exertional malaise: Mentally tired after the slightest effort | Improves | -2.39 |
Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 3.05 |
Post-exertional malaise: Post-exertional malaise | Worsen | 0 |
Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 3.64 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 0 |
Sleep: Daytime drowsiness | Worsen | 3.1 |
Sleep: Need to nap daily | Improves | -2.82 |
Sleep: Problems staying asleep | Worsen | 2.3 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.92 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Worsen | 3.47 |
ADHD | Improves | -4.21 |
Allergies | Improves | -2.23 |
Alzheimer's disease | Worsen | 4.76 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -2.62 |
Ankylosing spondylitis | Improves | -4.71 |
Asthma | Improves | -4 |
Atherosclerosis | Worsen | 3.08 |
Autism | Worsen | 5.94 |
Barrett esophagus cancer | Improves | -2.61 |
Brain Trauma | Worsen | 3.83 |
Carcinoma | Improves | -4.08 |
Celiac Disease | Worsen | 2.45 |
Chronic Fatigue Syndrome | Worsen | 5.27 |
Chronic Kidney Disease | Worsen | 2.58 |
Chronic urticaria (Hives) | Improves | -3.49 |
Colorectal Cancer | Improves | -6.29 |
Coronary artery disease | Worsen | 3.6 |
Crohn's Disease | Improves | -4.32 |
Depression | Improves | -4.81 |
Epilepsy | Worsen | 4.1 |
Fibromyalgia | Worsen | 3.44 |
Functional constipation / chronic idiopathic constipation | Improves | -3.38 |
gallstone disease (gsd) | Improves | -3.09 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.39 |
Generalized anxiety disorder | Improves | -3.32 |
Gout | Improves | -1.13 |
Graves' disease | Improves | -2.75 |
Hashimoto's thyroiditis | Improves | -3.63 |
High Blood Pressure | Worsen | 4.92 |
Histamine Issues | Improves | -3.58 |
Histamine Issues From Ubiome | Worsen | 2.96 |
hypercholesterolemia (High Cholesterol) | Improves | -3.47 |
Hyperlipidemia (High Blood Fats) | Worsen | 3.31 |
hypertension (High Blood Pressure | Improves | -3.68 |
IgA nephropathy (IgAN) | Worsen | 4.7 |
Inflammatory Bowel Disease | Worsen | 2.32 |
Insomnia | Worsen | 2.71 |
Irritable Bowel Syndrome | Improves | -2.13 |
Liver Cirrhosis | Worsen | 3.72 |
ME/CFS with IBS | Improves | -0.53 |
ME/CFS without IBS | Improves | -3.94 |
Metabolic Syndrome | Improves | -1.91 |
Mood Disorders | Worsen | 0 |
Multiple Sclerosis | Improves | -3.52 |
Multiple system atrophy (MSA) | Worsen | 2.99 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -3.31 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 3.58 |
Obesity | Improves | -4.86 |
Osteoporosis | Improves | -4.33 |
Parkinson's Disease | Worsen | 4.65 |
Psoriasis | Improves | -4.23 |
Rheumatoid arthritis | Worsen | 4.35 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.34 |
Rosacea | Worsen | 2.46 |
Schizophrenia | Improves | -2.66 |
Sclerosis | Improves | -2.26 |
Sjögren syndrome | Improves | -3.24 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.21 |
Stress / posttraumatic stress disorder | Improves | -4.26 |
Systemic Lupus Erythematosus | Improves | -4.12 |
Type 1 Diabetes | Improves | -3.99 |
Type 2 Diabetes | Improves | -4.75 |
Ulcerative colitis | Worsen | 3.35 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.