We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -0.94 |
| Age: 20-30 | Worsen | 3.13 |
| Age: 50-60 | Improves | -1.51 |
| Age: 60-70 | Worsen | 3.2 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -2.82 |
| Asymptomatic: No Health Issues | Improves | -2.24 |
| Autism: Official Diagnosis | Improves | -3.87 |
| Autonomic Manifestations: cardiac arrhythmias | Worsen | 4.44 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 3.24 |
| Autonomic Manifestations: irritable bowel syndrome | Worsen | 1.71 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 4.07 |
| Autonomic Manifestations: palpitations | Worsen | 3.77 |
| Autonomic Manifestations: urinary frequency dysfunction | Worsen | 2.7 |
| Autonomic: Blurred or tunnel vision after standing | Worsen | 0.1 |
| Autonomic: Dizziness or fainting | Worsen | 1.52 |
| Autonomic: Graying or blacking out after standing | Worsen | 2.92 |
| Autonomic: Heart rate increase after standing | Worsen | 3.05 |
| Autonomic: Inability to tolerate an upright position | Improves | -3.58 |
| Autonomic: Irregular heartbeats | Improves | -1.31 |
| Autonomic: Ocassional Tachycardia (Rapid heart beat) | Worsen | 1.33 |
| Autonomic: Shortness of breath | Improves | -1.61 |
| Blood Type: A Positive | Worsen | 2.96 |
| Blood Type: O Positive | Improves | -4.44 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -1.8 |
| Comorbid-Mouth: Dry Mouth | Worsen | 3.35 |
| Comorbid-Mouth: Mouth Sores | Worsen | 1.84 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -4.08 |
| Comorbid: Constipation and Diarrohea (not explosions) | Improves | -1.36 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.54 |
| Comorbid: Fibromyalgia | Worsen | 4.04 |
| Comorbid: High Anxiety | Improves | -4.31 |
| Comorbid: Histamine or Mast Cell issues | Improves | -2.86 |
| Comorbid: Hypothyroidism | Improves | -3.65 |
| Comorbid: Inflammatory bowel disease | Improves | -3.58 |
| Comorbid: Methylation issues (MTHFR) | Improves | -3.01 |
| Comorbid: Migraine | Improves | -3.12 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.75 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -2.56 |
| DePaul University Fatigue Questionnaire : Abdomen pain | Improves | -4.08 |
| DePaul University Fatigue Questionnaire : Allergies | Improves | -3.92 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Improves | -4.12 |
| DePaul University Fatigue Questionnaire : Depression | Improves | -3.51 |
| DePaul University Fatigue Questionnaire : Difficulty falling asleep | Improves | -4.52 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Improves | -4.6 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Improves | -4.33 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -5.23 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Improves | -4.09 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -4.95 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -4.74 |
| DePaul University Fatigue Questionnaire : Upset stomach | Improves | -3.59 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -4.38 |
| Gender: Female | Improves | -0.95 |
| General: Depression | Worsen | 1.71 |
| General: Fatigue | Worsen | 2.48 |
| General: Headaches | Worsen | 1.62 |
| General: Myalgia (pain) | Worsen | 1.71 |
| General: Sinus issues with headaches | Improves | -3.09 |
| Immune Manifestations: Abdominal Pain | Improves | -3.76 |
| Immune Manifestations: Alcohol Intolerant | Improves | -2.56 |
| Immune Manifestations: Bloating | Worsen | 3.1 |
| Immune Manifestations: Constipation | Worsen | 0.58 |
| Immune Manifestations: Diarrhea | Worsen | 3.5 |
| Immune Manifestations: general malaise | Worsen | 1.71 |
| Immune Manifestations: Hair loss | Improves | -1.9 |
| Immune Manifestations: Inflammation (General) | Improves | -3.95 |
| Immune Manifestations: medication sensitivities. | Worsen | 3.05 |
| Immune Manifestations: Mucus in the stool | Improves | -4.04 |
| Immune Manifestations: new food sensitivities | Worsen | 3.03 |
| Infection: Human Herpesvirus 6 (HHV6) | Improves | -3.21 |
| Infection: Mycoplasma | Worsen | 1.99 |
| Infection: Parasite - Other | Improves | -3.92 |
| Joint: Redness | Worsen | 2.82 |
| Joint: Stiffness and swelling | Worsen | 2.44 |
| Joint: Sudden and severe episodes of pain | Worsen | 1.85 |
| Joint: Tenderness | Improves | -4 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -2.52 |
| Neurocognitive: Difficulty paying attention for a long period of time | Improves | -2.83 |
| Neurocognitive: Difficulty understanding things | Improves | -1.68 |
| Neurocognitive: Problems remembering things | Improves | -2.83 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -2.76 |
| Neuroendocrine Manifestations: Air Hunger | Worsen | 2.91 |
| Neuroendocrine Manifestations: cold extremities | Improves | -3.05 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Worsen | 2.89 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 2.1 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.36 |
| Neuroendocrine Manifestations: loss of adaptability | Improves | -2.84 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -2.47 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -4.13 |
| Neuroendocrine Manifestations: subnormal body temperature | Improves | -2.93 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 1.71 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 1.59 |
| Neuroendocrine: Alcohol intolerance | Improves | -2.37 |
| Neuroendocrine: Chills or shivers | Worsen | 3.36 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 2.53 |
| Neuroendocrine: Feeling hot or cold for no reason | Worsen | 2.71 |
| Neuroendocrine: Feeling like you have a high temperature | Worsen | 2.71 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 3.11 |
| Neuroendocrine: Lack of appetite | Worsen | 4.13 |
| Neuroendocrine: Lost or gained weight without trying | Worsen | 0.75 |
| Neurological-Audio: hypersensitivity to noise | Improves | -2.83 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -3.27 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 3.48 |
| Neurological-Sleep: Insomnia | Worsen | 2.55 |
| Neurological-Sleep: Night Sweats | Worsen | 1.71 |
| Neurological-Sleep: Sleep Apnea | Worsen | 1.97 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 3.65 |
| Neurological-Vision: Blurred Vision | Worsen | 3.59 |
| Neurological-Vision: inability to focus eye/vision | Improves | -1.23 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 0.94 |
| Neurological: Confusion | Worsen | 2.97 |
| Neurological: Difficulty processing information (Understanding) | Improves | -2.17 |
| Neurological: Difficulty reading | Worsen | 3.14 |
| Neurological: emotional overload | Worsen | 0 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 2.98 |
| Neurological: fasciculations | Worsen | 3.71 |
| Neurological: High degree of Empathy before onset | Worsen | 0 |
| Neurological: Impairment of concentration | Worsen | 2.98 |
| Neurological: Joint hypermobility | Improves | -3.94 |
| Neurological: Seasonal Affective Disorder (SAD) | Improves | -0.92 |
| Neurological: Short-term memory issues | Worsen | 1.56 |
| Neurological: Slowed speech | Worsen | 3.49 |
| Neurological: Spatial instability and disorientation | Worsen | 0 |
| Neurological: Word-finding problems | Worsen | 1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -4.28 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.55 |
| Official Diagnosis: Chronic Fatigue Syndrome | Worsen | 2.08 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -1.91 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -3.52 |
| Onset: 2010-2020 | Worsen | 0.58 |
| Onset: Gradual | Worsen | 1.67 |
| Onset: less than 02 years since onset | Worsen | 0 |
| Other: Sensitivity to mold | Worsen | 2.3 |
| Pain: Chest pain | Improves | -2.96 |
| Pain: Joint pain | Worsen | 2.83 |
| Pain: Myofascial pain | Worsen | 1.49 |
| Pain: Sensitivity to pain | Improves | -2.49 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Improves | -3.51 |
| Post-exertional malaise: Mentally tired after the slightest effort | Improves | -3.34 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.89 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 0 |
| Sleep: Daytime drowsiness | Worsen | 2.87 |
| Sleep: Problems staying asleep | Worsen | 3.61 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 3.13 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 3.24 |
| ADHD | Improves | -5.47 |
| Allergic Rhinitis (Hay Fever) | Worsen | 2.67 |
| Allergies | Improves | -3.61 |
| Alzheimer's disease | Worsen | 4.89 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -4.6 |
| Ankylosing spondylitis | Improves | -4.75 |
| Asthma | Improves | -3.98 |
| Atherosclerosis | Worsen | 3.18 |
| Autism | Worsen | 6.13 |
| Barrett esophagus cancer | Improves | -2.61 |
| Bipolar Disorder | Improves | -0.52 |
| Brain Trauma | Worsen | 4.1 |
| Carcinoma | Improves | -4.08 |
| Celiac Disease | Worsen | 4.98 |
| Cerebral Palsy | Improves | -0.57 |
| Chronic Fatigue Syndrome | Worsen | 5.27 |
| Chronic Kidney Disease | Worsen | 2.58 |
| Chronic Lyme | Worsen | 3.01 |
| Chronic Urticaria (Hives) | Improves | -3.49 |
| Colorectal Cancer | Improves | -6.29 |
| Coronary artery disease | Worsen | 3.6 |
| COVID-19 | Improves | -3.85 |
| Crohn's Disease | Improves | -4.32 |
| Depression | Improves | -4.81 |
| Eczema | Worsen | 4.61 |
| Epilepsy | Worsen | 4.1 |
| Fibromyalgia | Worsen | 1.66 |
| Functional constipation / chronic idiopathic constipation | Worsen | 3.96 |
| gallstone disease (gsd) | Improves | -3.09 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.39 |
| Generalized anxiety disorder | Improves | -3.32 |
| Gout | Improves | -1.13 |
| Graves' disease | Improves | -2.75 |
| Hashimoto's thyroiditis | Improves | -3.63 |
| High Blood Pressure | Worsen | 4.92 |
| Histamine Issues | Improves | -3.58 |
| Histamine Issues From Ubiome | Worsen | 2.96 |
| hypercholesterolemia (High Cholesterol) | Improves | -3.47 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.31 |
| hypertension (High Blood Pressure | Improves | -3.54 |
| IgA nephropathy (IgAN) | Worsen | 4.7 |
| Inflammatory Bowel Disease | Worsen | 4.31 |
| Insomnia | Worsen | 2.71 |
| Irritable Bowel Syndrome | Improves | -3.7 |
| Liver Cirrhosis | Worsen | 3.72 |
| ME/CFS with IBS | Improves | -0.53 |
| ME/CFS without IBS | Improves | -3.94 |
| Metabolic Syndrome | Improves | -1.91 |
| Mood Disorders | Worsen | 0 |
| Multiple Sclerosis | Improves | -3.96 |
| Multiple system atrophy (MSA) | Worsen | 2.99 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -3.31 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 4.34 |
| NonCeliac Gluten Sensitivity | Worsen | 1.56 |
| Obesity | Improves | -4.04 |
| Osteoarthritis | Improves | -3.79 |
| Osteoporosis | Improves | -4.33 |
| Parkinson's Disease | Worsen | 5.03 |
| Psoriasis | Improves | -5.1 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.02 |
| Rosacea | Worsen | 2.46 |
| Schizophrenia | Improves | -5.03 |
| Sjögren syndrome | Improves | -3.85 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.21 |
| Stress / posttraumatic stress disorder | Improves | -4.39 |
| Systemic Lupus Erythematosus | Improves | -4.65 |
| Type 1 Diabetes | Improves | -1.05 |
| Type 2 Diabetes | Improves | -4.94 |
| Ulcerative colitis | Worsen | 4.3 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.