We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 20-30 | Worsen | 3.37 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 1.85 |
Asymptomatic: No Health Issues | Worsen | 2.65 |
Autism: Official Diagnosis | Worsen | 1.76 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 3.5 |
Autonomic: Graying or blacking out after standing | Improves | -1.76 |
Autonomic: Heart rate increase after standing | Worsen | 3.21 |
Autonomic: Inability to tolerate an upright position | Improves | -1.32 |
Autonomic: Irregular heartbeats | Worsen | 3.05 |
Autonomic: Shortness of breath | Worsen | 1.67 |
Blood Type: A Positive | Worsen | 1.76 |
Blood Type: O Positive | Improves | -2.93 |
Comorbid-Mouth: Dry Mouth | Improves | -3.01 |
Comorbid-Mouth: Mouth Sores | Improves | -1.84 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.29 |
Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.04 |
Comorbid: Fibromyalgia | Improves | -3.15 |
Comorbid: High Anxiety | Worsen | 2.78 |
Comorbid: Histamine or Mast Cell issues | Improves | -3.16 |
Comorbid: Hypothyroidism | Worsen | 3.05 |
Comorbid: Inflammatory bowel disease | Improves | -2.06 |
Comorbid: Migraine | Worsen | 3.41 |
Comorbid: Multiple Chemical Sensitivity | Improves | -3.46 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 2.78 |
DePaul University Fatigue Questionnaire : Allergies | Worsen | 3 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 0.81 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 3.63 |
DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.71 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.63 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.48 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 2.75 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3 |
General: Depression | Improves | -1.71 |
General: Fatigue | Improves | -1.79 |
General: Headaches | Worsen | 2.41 |
General: Myalgia (pain) | Improves | -0.29 |
General: Sinus issues with headaches | Worsen | 2.65 |
Immune Manifestations: Abdominal Pain | Worsen | 3.05 |
Immune Manifestations: Alcohol Intolerant | Improves | -2.75 |
Immune Manifestations: Diarrhea | Improves | -1.93 |
Immune Manifestations: Hair loss | Worsen | 1.9 |
Immune Manifestations: Inflammation (General) | Improves | -3.87 |
Immune Manifestations: Mucus in the stool | Worsen | 1.29 |
Immune Manifestations: tender lymph nodes | Improves | -0.06 |
Immune: Chronic Sinusitis | Worsen | 2.95 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 3.46 |
Infection: Mycoplasma | Worsen | 3.05 |
Infection: Parasite - Other | Worsen | 3.05 |
Joint: Stiffness and swelling | Improves | -1.8 |
Joint: Sudden and severe episodes of pain | Worsen | 1.85 |
Joint: Tenderness | Worsen | 3.44 |
Neurocognitive: Brain Fog | Worsen | 2.95 |
Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.9 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.66 |
Neuroendocrine Manifestations: Muscle weakness | Improves | -3.57 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -1.32 |
Neuroendocrine Manifestations: subnormal body temperature | Worsen | 3.05 |
Neuroendocrine: Alcohol intolerance | Worsen | 3.05 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -1.71 |
Neuroendocrine: Feeling like you have a low temperature | Improves | -2.74 |
Neuroendocrine: Lost or gained weight without trying | Improves | -1.64 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.1 |
Neurological-Sleep: Sleep Apnea | Worsen | 2.56 |
Neurological-Vision: Blurred Vision | Improves | -1.5 |
Neurological-Vision: inability to focus eye/vision | Worsen | 2.36 |
Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 3.05 |
Neurological: Cognitive/Sensory Overload | Improves | -1.64 |
Neurological: emotional overload | Improves | -2.74 |
Neurological: Executive Decision Making (Difficulty making) | Improves | -1.72 |
Neurological: fasciculations | Improves | -4.04 |
Neurological: High degree of Empathy before onset | Improves | -2.74 |
Neurological: Impairment of concentration | Worsen | 2.41 |
Neurological: Joint hypermobility | Worsen | 3.43 |
Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.49 |
Neurological: Short-term memory issues | Improves | -2.96 |
Neurological: Spatial instability and disorientation | Improves | -2.74 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 1.23 |
Official Diagnosis: Irritable Bowel Syndrome | Improves | -3.16 |
Official Diagnosis: Mast Cell Dysfunction | Improves | -2.16 |
Onset: 2010-2020 | Worsen | 3.05 |
Onset: Gradual | Improves | -1.95 |
Other: Sensitivity to mold | Improves | -1.64 |
Pain: Chest pain | Worsen | 2.73 |
Pain: Eye pain | Improves | -2.9 |
Pain: Sensitivity to pain | Worsen | 2.45 |
Post-exertional malaise: General | Improves | -2.74 |
Post-exertional malaise: Mentally tired after the slightest effort | Improves | -2.74 |
Post-exertional malaise: Physically drained or sick after mild activity | Improves | -2.74 |
Post-exertional malaise: Post-exertional malaise | Improves | -2.74 |
Post-exertional malaise: Rapid cognitive fatigability, | Improves | -2.74 |
Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Improves | -2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Worsen | 0.34 |
ADHD | Worsen | 3.63 |
Allergies | Worsen | 3.38 |
Alzheimer's disease | Worsen | 3.99 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -3.19 |
Ankylosing spondylitis | Worsen | 4.69 |
Asthma | Improves | -3.12 |
Atherosclerosis | Improves | -3.7 |
Autism | Improves | -4.55 |
Barrett esophagus cancer | Worsen | 4.35 |
Brain Trauma | Worsen | 0.21 |
Carcinoma | Improves | -3.85 |
Celiac Disease | Improves | -2.58 |
Chronic Fatigue Syndrome | Improves | -4.42 |
Chronic Kidney Disease | Worsen | 2.82 |
Chronic urticaria (Hives) | Worsen | 3.37 |
Colorectal Cancer | Improves | -4.92 |
Coronary artery disease | Improves | -2.77 |
Crohn's Disease | Worsen | 4.21 |
cystic fibrosis | Improves | -3.63 |
Depression | Improves | -2.81 |
Epilepsy | Worsen | 2.45 |
Fibromyalgia | Worsen | 3.08 |
Functional constipation / chronic idiopathic constipation | Improves | -2.83 |
gallstone disease (gsd) | Worsen | 1.39 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 3.63 |
Generalized anxiety disorder | Worsen | 2.86 |
Graves' disease | Improves | -3.86 |
Hashimoto's thyroiditis | Worsen | 2.49 |
High Blood Pressure | Improves | -3.02 |
Histamine Issues | Improves | -3.57 |
hypercholesterolemia (High Cholesterol) | Worsen | 3.14 |
Hyperlipidemia (High Blood Fats) | Worsen | 4.49 |
hypertension (High Blood Pressure | Worsen | 2.99 |
IgA nephropathy (IgAN) | Worsen | 3.79 |
Inflammatory Bowel Disease | Improves | -2.73 |
Insomnia | Worsen | 4.06 |
Irritable Bowel Syndrome | Worsen | 4.28 |
Juvenile idiopathic arthritis | Worsen | 2.99 |
Liver Cirrhosis | Improves | -4.43 |
ME/CFS with IBS | Improves | -4.02 |
ME/CFS without IBS | Improves | -4.57 |
Metabolic Syndrome | Worsen | 1.09 |
Mood Disorders | Worsen | 2.74 |
Multiple Sclerosis | Worsen | 4.72 |
Multiple system atrophy (MSA) | Worsen | 0.55 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -1.48 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.78 |
NonCeliac Gluten Sensitivity | Improves | -1.48 |
Obesity | Improves | -2.73 |
Osteoporosis | Improves | -3.73 |
Parkinson's Disease | Worsen | 4.95 |
Psoriasis | Improves | -4.39 |
Rheumatoid arthritis | Worsen | 4.86 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.16 |
Rosacea | Worsen | 3.99 |
Schizophrenia | Worsen | 2.85 |
Sclerosis | Worsen | 2.9 |
Sjögren syndrome | Improves | -2.96 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -4.54 |
Stress / posttraumatic stress disorder | Improves | -4.66 |
Systemic Lupus Erythematosus | Improves | -5.07 |
Type 1 Diabetes | Worsen | 4.4 |
Type 2 Diabetes | Worsen | 4.51 |
Ulcerative colitis | Improves | -1.15 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.