We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Comorbid-Mouth: Dry Mouth | Improves | -2.74 |
| Neuroendocrine: Feeling like you have a low temperature | Improves | -2.74 |
| Neurological: emotional overload | Improves | -2.74 |
| Neurological: fasciculations | Improves | -2.74 |
| Neurological: High degree of Empathy before onset | Improves | -2.74 |
| Neurological: Short-term memory issues | Improves | -2.74 |
| Neurological: Spatial instability and disorientation | Improves | -2.74 |
| Post-exertional malaise: General | Improves | -2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Improves | -2.74 |
| Post-exertional malaise: Physically drained or sick after mild activity | Improves | -2.74 |
| Post-exertional malaise: Post-exertional malaise | Improves | -2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Improves | -2.74 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Improves | -2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Allergies | Improves | -3.25 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -2.74 |
| Ankylosing spondylitis | Improves | -3.94 |
| Asthma | Improves | -2.74 |
| Atherosclerosis | Improves | -2.83 |
| Autism | Worsen | 0 |
| Brain Trauma | Worsen | 2.74 |
| Carcinoma | Improves | -2.41 |
| Celiac Disease | Improves | -2.42 |
| Chronic Fatigue Syndrome | Worsen | 2.43 |
| Chronic Kidney Disease | Improves | -2.41 |
| Chronic urticaria (Hives) | Improves | -3.06 |
| Colorectal Cancer | Improves | -3.77 |
| Crohn's Disease | Worsen | 3.27 |
| cystic fibrosis | Improves | -3.22 |
| Depression | Worsen | 3.92 |
| Epilepsy | Worsen | 2.54 |
| Generalized anxiety disorder | Improves | -2.86 |
| Graves' disease | Improves | -2.74 |
| High Blood Pressure | Improves | -3.11 |
| Histamine Issues | Improves | -2.73 |
| IgA nephropathy (IgAN) | Worsen | 1.35 |
| Inflammatory Bowel Disease | Improves | -3.86 |
| Irritable Bowel Syndrome | Improves | -2.36 |
| Liver Cirrhosis | Improves | -3.2 |
| ME/CFS with IBS | Worsen | 0 |
| ME/CFS without IBS | Worsen | 2.43 |
| Mood Disorders | Worsen | 2.74 |
| Multiple Sclerosis | Improves | -2.89 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Obesity | Worsen | 1.7 |
| Osteoporosis | Improves | -2.41 |
| Parkinson's Disease | Worsen | 2.74 |
| Psoriasis | Worsen | 0.91 |
| Rheumatoid arthritis | Improves | -3.37 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 1.36 |
| Rosacea | Worsen | 0 |
| Schizophrenia | Improves | -2.74 |
| Sjögren syndrome | Improves | -2.41 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.23 |
| Stress / posttraumatic stress disorder | Worsen | 4.01 |
| Type 2 Diabetes | Worsen | 2.02 |
| Ulcerative colitis | Improves | -2.28 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.