We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.48 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -1.85 |
| Asymptomatic: No Health Issues | Improves | -1.6 |
| Autism: Official Diagnosis | Worsen | 1.76 |
| Autonomic: Graying or blacking out after standing | Improves | -1.76 |
| Autonomic: Inability to tolerate an upright position | Worsen | 3.17 |
| Blood Type: A Positive | Worsen | 2.42 |
| Blood Type: O Positive | Worsen | 3.52 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.37 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 2.38 |
| Comorbid: High Anxiety | Worsen | 3.16 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 2.95 |
| Comorbid: Inflammatory bowel disease | Worsen | 3.4 |
| Comorbid: Migraine | Worsen | 3.38 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 1.8 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.53 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.89 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.51 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.52 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.52 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.92 |
| General: Headaches | Improves | -1.62 |
| General: Sinus issues with headaches | Worsen | 1.8 |
| Immune Manifestations: Abdominal Pain | Worsen | 2.48 |
| Immune Manifestations: Diarrhea | Worsen | 1.93 |
| Immune Manifestations: Inflammation (General) | Worsen | 3.87 |
| Immune Manifestations: Mucus in the stool | Worsen | 2.92 |
| Immune Manifestations: tender lymph nodes | Improves | -2.9 |
| Immune: Tender / sore lymph nodes | Worsen | 2.88 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.76 |
| Joint: Stiffness and swelling | Worsen | 0.46 |
| Joint: Sudden and severe episodes of pain | Improves | -1.85 |
| Joint: Tenderness | Worsen | 1.85 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 3.47 |
| Neurocognitive: Slowness of thought | Worsen | 2.48 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 2.63 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.17 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.47 |
| Neuroendocrine: Alcohol intolerance | Worsen | 3.32 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 1.8 |
| Neurological: Cognitive/Sensory Overload | Improves | -1.64 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 2.42 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Joint hypermobility | Worsen | 1.8 |
| Neurological: Short-term memory issues | Worsen | 2.47 |
| Neurological: Slowed speech | Improves | -1.61 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.35 |
| Official Diagnosis: Autoimmune Disease | Worsen | 3.61 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 3.16 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 0.47 |
| Onset: Gradual | Improves | -1.95 |
| Pain: Sensitivity to pain | Worsen | 1.8 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.48 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.74 |
| Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Problems staying asleep | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -3.47 |
| ADHD | Worsen | 3.56 |
| Allergies | Improves | -2.98 |
| Alzheimer's disease | Improves | -4.48 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.48 |
| Ankylosing spondylitis | Worsen | 4.92 |
| Asthma | Worsen | 3.9 |
| Atherosclerosis | Improves | -3.98 |
| Autism | Improves | -3.63 |
| Barrett esophagus cancer | Improves | -2.15 |
| Brain Trauma | Improves | -2.32 |
| Carcinoma | Improves | -3.18 |
| Celiac Disease | Improves | -3.66 |
| Chronic Fatigue Syndrome | Improves | -4.49 |
| Chronic Kidney Disease | Improves | -3.61 |
| Chronic urticaria (Hives) | Improves | -2.11 |
| Colorectal Cancer | Worsen | 3.04 |
| Coronary artery disease | Improves | -2.95 |
| Crohn's Disease | Improves | -4.49 |
| cystic fibrosis | Improves | -3.57 |
| Depression | Improves | -2.88 |
| Epilepsy | Improves | -3.78 |
| Fibromyalgia | Improves | -3.9 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -2.72 |
| Generalized anxiety disorder | Improves | -4.4 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Improves | -3.48 |
| High Blood Pressure | Improves | -3.09 |
| Histamine Issues | Improves | -4.49 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.63 |
| IgA nephropathy (IgAN) | Improves | -3.95 |
| Inflammatory Bowel Disease | Improves | -5.04 |
| Irritable Bowel Syndrome | Improves | -4.84 |
| Liver Cirrhosis | Improves | -4.82 |
| ME/CFS with IBS | Worsen | 0.26 |
| ME/CFS without IBS | Worsen | 3.03 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Improves | -2.94 |
| Multiple system atrophy (MSA) | Improves | -1.3 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -1.37 |
| Obesity | Worsen | 2.22 |
| Osteoporosis | Worsen | 2.55 |
| Parkinson's Disease | Worsen | 4.62 |
| Psoriasis | Worsen | 2.14 |
| Rheumatoid arthritis | Improves | -4.63 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.2 |
| Rosacea | Improves | -2.26 |
| Schizophrenia | Worsen | 3.78 |
| Sclerosis | Improves | -3.37 |
| Sjögren syndrome | Improves | -3.62 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -4.54 |
| Stress / posttraumatic stress disorder | Improves | -4.72 |
| Systemic Lupus Erythematosus | Improves | -2.81 |
| Type 1 Diabetes | Improves | -2.22 |
| Type 2 Diabetes | Improves | -4.53 |
| Ulcerative colitis | Improves | -3.73 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.