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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Asymptomatic: No Health Issues	Worsen	1.67
Autonomic Manifestations: cardiac arrhythmias	Worsen	2.83
Autonomic: Inability to tolerate an upright position	Improves	-2.16
Comorbid-Mouth: Mouth Sores	Worsen	2.48
Comorbid: High Anxiety	Improves	-2.16
Comorbid: Inflammatory bowel disease	Improves	-2.16
DePaul University Fatigue Questionnaire : Fatigue	Improves	-2.16
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Improves	-2.16
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Improves	-2.16
Immune Manifestations: Abdominal Pain	Worsen	2.48
Immune Manifestations: Inflammation (General)	Improves	-2.16
Immune Manifestations: tender lymph nodes	Worsen	2.98
Joint: Tenderness	Improves	-2.16
Neurocognitive: Slowness of thought	Worsen	2.48
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-2.98
Neuroendocrine Manifestations: worsening of symptoms with stress.	Worsen	2.48
Neuroendocrine: Lack of appetite	Worsen	2.16
Neuroendocrine: Sweating hands	Worsen	2.16
Pain: Sensitivity to pain	Improves	-2.16

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Allergies	Worsen	2.7
Alzheimer's disease	Worsen	2.98
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	0
Ankylosing spondylitis	Worsen	1.38
Asthma	Improves	-2.98
Atherosclerosis	Improves	-4.45
Autism	Worsen	2.6
Barrett esophagus cancer	Worsen	2.83
Carcinoma	Improves	-3.3
Celiac Disease	Improves	-3.49
Chronic Fatigue Syndrome	Improves	-4.17
Chronic Kidney Disease	Improves	-2.41
Chronic urticaria (Hives)	Improves	-4.03
Colorectal Cancer	Improves	-3.95
Crohn's Disease	Improves	-4.77
cystic fibrosis	Improves	-3.45
Depression	Improves	-2.74
Epilepsy	Improves	-3.36
Fibromyalgia	Worsen	2.98
gallstone disease (gsd)	Improves	-2.98
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Worsen	3.46
Generalized anxiety disorder	Improves	-3.76
High Blood Pressure	Worsen	2.24
Histamine Issues	Improves	-3.75
IgA nephropathy (IgAN)	Worsen	3.67
Inflammatory Bowel Disease	Improves	-4.64
Irritable Bowel Syndrome	Improves	-3.36
Liver Cirrhosis	Improves	-3.83
ME/CFS with IBS	Improves	-3.95
ME/CFS without IBS	Improves	-4.39
Multiple Sclerosis	Improves	-2.79
neuropsychiatric disorders (PANDAS, PANS)	Improves	-2.42
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-2.98
Obesity	Improves	-3.64
Osteoporosis	Improves	-3.4
Psoriasis	Improves	-4.14
Rheumatoid arthritis	Worsen	3
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-3.35
Rosacea	Worsen	2.98
Schizophrenia	Worsen	2.98
Sclerosis	Worsen	2.98
Sjögren syndrome	Improves	-3.3
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-4.04
Stress / posttraumatic stress disorder	Improves	-4.47
Systemic Lupus Erythematosus	Improves	-1.45
Type 1 Diabetes	Worsen	3.11
Type 2 Diabetes	Worsen	3.38
Ulcerative colitis	Improves	-2.67

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.