We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 60-70 | Worsen | 2.39 |
| Asymptomatic: No Health Issues | Worsen | 1.9 |
| Autism: Official Diagnosis | Worsen | 1.76 |
| Autonomic Manifestations: cardiac arrhythmias | Worsen | 1.15 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -1.7 |
| Autonomic Manifestations: irritable bowel syndrome | Worsen | 2.39 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 0.19 |
| Autonomic: Inability to tolerate an upright position | Worsen | 3.05 |
| Autonomic: Irregular heartbeats | Worsen | 3.05 |
| Autonomic: Shortness of breath | Worsen | 1.67 |
| Blood Type: A Positive | Worsen | 1.76 |
| Blood Type: O Positive | Improves | -1.51 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.39 |
| Comorbid-Mouth: Dry Mouth | Improves | -3.05 |
| Comorbid-Mouth: Mouth Sores | Improves | -1.84 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.29 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.58 |
| Comorbid: Fibromyalgia | Worsen | 2.71 |
| Comorbid: High Anxiety | Worsen | 2.87 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 2.39 |
| Comorbid: Hypothyroidism | Worsen | 3.05 |
| Comorbid: Inflammatory bowel disease | Worsen | 3.21 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -3.55 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 3.44 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 0.54 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.25 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.05 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.76 |
| General: Depression | Improves | -1.71 |
| General: Fatigue | Improves | -2.9 |
| General: Headaches | Worsen | 2.39 |
| Immune Manifestations: Abdominal Pain | Worsen | 3.05 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 2.39 |
| Immune Manifestations: Bloating | Worsen | 2.39 |
| Immune Manifestations: Constipation | Worsen | 2.39 |
| Immune Manifestations: Diarrhea | Improves | -1.67 |
| Immune Manifestations: general malaise | Worsen | 2.39 |
| Immune Manifestations: Hair loss | Worsen | 1.9 |
| Immune Manifestations: Mucus in the stool | Worsen | 2.83 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 3.29 |
| Infection: Mycoplasma | Worsen | 3.05 |
| Infection: Parasite - Other | Worsen | 3.05 |
| Joint: Stiffness and swelling | Worsen | 2.39 |
| Joint: Tenderness | Worsen | 3.24 |
| Neurocognitive: Absent-mindedness or forgetfulness | Worsen | 2.39 |
| Neurocognitive: Brain Fog | Worsen | 2.39 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 2.39 |
| Neurocognitive: Slowness of thought | Worsen | 2.39 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -3.43 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.92 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.05 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 3.44 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 2.39 |
| Neuroendocrine: Alcohol intolerance | Worsen | 3.44 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -1.71 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 3.11 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -3.35 |
| Neurological-Audio: hypersensitivity to noise | Worsen | 3.44 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -2.96 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 0.34 |
| Neurological-Sleep: Insomnia | Worsen | 2.64 |
| Neurological-Sleep: Sleep Apnea | Improves | -1.97 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 3.44 |
| Neurological: Difficulty processing information (Understanding) | Worsen | 1.67 |
| Neurological: Difficulty reading | Worsen | 2.39 |
| Neurological: fasciculations | Improves | -2.84 |
| Neurological: Impairment of concentration | Worsen | 2.39 |
| Neurological: Joint hypermobility | Worsen | 3.05 |
| Neurological: Seasonal Affective Disorder (SAD) | Improves | -0.86 |
| Neurological: Short-term memory issues | Improves | -1.56 |
| Neurological: Word-finding problems | Worsen | 1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.87 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 2.39 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 3.25 |
| Onset: 2010-2020 | Worsen | 2.39 |
| Onset: Gradual | Improves | -1.67 |
| Other: Sensitivity to mold | Improves | -2.3 |
| Pain: Chest pain | Improves | -2.96 |
| Pain: Sensitivity to pain | Worsen | 3.05 |
| Sleep: Daytime drowsiness | Worsen | 2.39 |
| Sleep: Problems staying asleep | Worsen | 1.72 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.39 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 3.13 |
| ADHD | Worsen | 3.55 |
| Allergic Rhinitis (Hay Fever) | Worsen | 2.56 |
| Allergies | Improves | -2.51 |
| Alzheimer's disease | Worsen | 4.44 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -3.42 |
| Ankylosing spondylitis | Worsen | 3.05 |
| Asthma | Worsen | 1.09 |
| Atherosclerosis | Worsen | 4.47 |
| Autism | Improves | -4.18 |
| Barrett esophagus cancer | Worsen | 3.01 |
| Bipolar Disorder | Worsen | 2.43 |
| Brain Trauma | Worsen | 2.86 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -4.06 |
| Cerebral Palsy | Improves | -1.38 |
| Chronic Fatigue Syndrome | Worsen | 2.81 |
| Chronic Kidney Disease | Worsen | 3.34 |
| Chronic Urticaria (Hives) | Improves | -0.92 |
| Colorectal Cancer | Worsen | 1.54 |
| Coronary artery disease | Improves | -1.09 |
| COVID-19 | Worsen | 1.34 |
| Crohn's Disease | Worsen | 4.75 |
| cystic fibrosis | Improves | -3.57 |
| Depression | Improves | -2.58 |
| Epilepsy | Improves | -2.7 |
| Fibromyalgia | Worsen | 3.12 |
| Functional constipation / chronic idiopathic constipation | Improves | -3.94 |
| gallstone disease (gsd) | Worsen | 3.05 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 3.67 |
| Generalized anxiety disorder | Worsen | 3.96 |
| Gout | Improves | -2.96 |
| Graves' disease | Worsen | 1.1 |
| Hashimoto's thyroiditis | Worsen | 3.3 |
| High Blood Pressure | Improves | -4.06 |
| Histamine Issues | Improves | -2.43 |
| hypercholesterolemia (High Cholesterol) | Improves | -2.87 |
| Hyperlipidemia (High Blood Fats) | Worsen | 4.23 |
| IgA nephropathy (IgAN) | Improves | -2.64 |
| Inflammatory Bowel Disease | Improves | -2.46 |
| Insomnia | Worsen | 3.05 |
| Irritable Bowel Syndrome | Improves | -2.13 |
| Liver Cirrhosis | Worsen | 4.62 |
| ME/CFS with IBS | Improves | -1.84 |
| ME/CFS without IBS | Worsen | 1.29 |
| Metabolic Syndrome | Worsen | 1.09 |
| Multiple Sclerosis | Worsen | 5.19 |
| Multiple system atrophy (MSA) | Worsen | 2.68 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.97 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 3.97 |
| Obesity | Improves | -4.43 |
| Osteoarthritis | Worsen | 2.64 |
| Osteoporosis | Improves | -2.73 |
| Parkinson's Disease | Worsen | 5.37 |
| Psoriasis | Worsen | 3.79 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 5.12 |
| Rosacea | Improves | -3.01 |
| Schizophrenia | Worsen | 2.77 |
| Sjögren syndrome | Improves | -3.01 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.21 |
| Stress / posttraumatic stress disorder | Worsen | 2.87 |
| Systemic Lupus Erythematosus | Worsen | 3.54 |
| Type 1 Diabetes | Improves | -2.68 |
| Type 2 Diabetes | Improves | -4.3 |
| Ulcerative colitis | Worsen | 3.57 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.