We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -3.58 |
| Age: 20-30 | Worsen | 2.48 |
| Age: 60-70 | Improves | -2.64 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -2.92 |
| Autonomic: Inability to tolerate an upright position | Improves | -2.92 |
| Autonomic: Irregular heartbeats | Improves | -2.92 |
| Blood Type: A Positive | Improves | -1.86 |
| Blood Type: O Positive | Improves | -3.17 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 1.62 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -2.92 |
| Comorbid: Fibromyalgia | Improves | -2.92 |
| Comorbid: High Anxiety | Improves | -2.92 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 1.7 |
| Comorbid: Inflammatory bowel disease | Improves | -2.92 |
| Comorbid: Migraine | Improves | -1.86 |
| Comorbid: Multiple Chemical Sensitivity | Worsen | 2.68 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -2.92 |
| Condition: ME/CFS with IBS | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Abdomen pain | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Depression | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -3.17 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 0 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.92 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -1.86 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 1.55 |
| General: Headaches | Worsen | 1.62 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 1.62 |
| Immune Manifestations: Inflammation (General) | Improves | -2.92 |
| Immune Manifestations: Mucus in the stool | Improves | -2.92 |
| Infection: Mycoplasma | Improves | -2.92 |
| Joint: Stiffness and swelling | Improves | -2.64 |
| Joint: Tenderness | Improves | -2.92 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 1.7 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 1.68 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -2.92 |
| Neuroendocrine: Alcohol intolerance | Improves | -2.64 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 1.7 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.92 |
| Neurological-Sleep: Insomnia | Improves | -2.92 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.92 |
| Neurological-Vision: photophobia (Light Sensitivity) | Improves | -2.92 |
| Neurological: Difficulty reading | Improves | -2.92 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 2.42 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Impairment of concentration | Worsen | 2.42 |
| Neurological: Short-term memory issues | Worsen | 2.74 |
| Neurological: Slowed speech | Worsen | 1.61 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.92 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.92 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -2.64 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.58 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Problems staying asleep | Improves | -2.9 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -2.64 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -4.63 |
| ADHD | Worsen | 4.18 |
| Allergic Rhinitis (Hay Fever) | Improves | -2.63 |
| Allergies | Worsen | 1.25 |
| Alzheimer's disease | Worsen | 2.4 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.29 |
| Ankylosing spondylitis | Worsen | 4.46 |
| Asthma | Improves | -2.98 |
| Atherosclerosis | Improves | -4 |
| Autism | Improves | -5.02 |
| Barrett esophagus cancer | Improves | -3.36 |
| Bipolar Disorder | Improves | -1.87 |
| Brain Trauma | Improves | -2.31 |
| Carcinoma | Improves | -2.41 |
| Celiac Disease | Improves | -4.17 |
| Cerebral Palsy | Worsen | 3.16 |
| Chronic Fatigue Syndrome | Improves | -4.52 |
| Chronic Kidney Disease | Improves | -3.25 |
| Chronic Lyme | Improves | -2.74 |
| Chronic Urticaria (Hives) | Improves | -3.7 |
| Colorectal Cancer | Improves | -4.36 |
| Coronary artery disease | Worsen | 2.32 |
| COVID-19 | Improves | -4.19 |
| Crohn's Disease | Improves | -5.33 |
| cystic fibrosis | Improves | -3.57 |
| Depression | Improves | -0.32 |
| Eczema | Improves | -4.92 |
| Epilepsy | Improves | -4.31 |
| Fibromyalgia | Improves | -4.34 |
| Functional constipation / chronic idiopathic constipation | Worsen | 3.68 |
| gallstone disease (gsd) | Improves | -3.73 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -4 |
| Generalized anxiety disorder | Improves | -4.54 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Improves | -2.93 |
| High Blood Pressure | Improves | -3.43 |
| Histamine Issues | Improves | -3.75 |
| Histamine Issues From Ubiome | Improves | -0.77 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.05 |
| hypertension (High Blood Pressure | Improves | -3.09 |
| IgA nephropathy (IgAN) | Improves | -3.56 |
| Inflammatory Bowel Disease | Improves | -5.03 |
| Irritable Bowel Syndrome | Improves | -5.2 |
| Liver Cirrhosis | Improves | -4.41 |
| ME/CFS with IBS | Improves | -2.93 |
| ME/CFS without IBS | Improves | -3.51 |
| Metabolic Syndrome | Improves | -3.01 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Improves | -3.75 |
| Multiple system atrophy (MSA) | Worsen | 1.75 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.46 |
| NonCeliac Gluten Sensitivity | Improves | -2.93 |
| Obesity | Improves | -4.65 |
| Osteoarthritis | Improves | -2.41 |
| Osteoporosis | Improves | -1.78 |
| Parkinson's Disease | Worsen | 5.15 |
| Psoriasis | Improves | -2.15 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -5.29 |
| Rosacea | Worsen | 2.74 |
| Schizophrenia | Worsen | 3.92 |
| Sjögren syndrome | Improves | -3.74 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.96 |
| Stress / posttraumatic stress disorder | Improves | -5.08 |
| Systemic Lupus Erythematosus | Improves | -3.89 |
| Type 1 Diabetes | Improves | -3.62 |
| Type 2 Diabetes | Improves | -4.35 |
| Ulcerative colitis | Improves | -4.96 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.