We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 20-30 | Worsen | 2.76 |
Age: 30-40 | Worsen | 1.79 |
Age: 50-60 | Worsen | 1.51 |
Age: 60-70 | Improves | -1.69 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 3.33 |
Asymptomatic: No Health Issues | Worsen | 2.63 |
Autism: Official Diagnosis | Worsen | 3.76 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 2.71 |
Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -3.05 |
Autonomic Manifestations: irritable bowel syndrome | Worsen | 2.46 |
Autonomic Manifestations: light-headedness | Worsen | 2.56 |
Autonomic Manifestations: Orthostatic intolerance | Improves | -3.32 |
Autonomic Manifestations: palpitations | Worsen | 2.92 |
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Improves | -2.63 |
Autonomic: Graying or blacking out after standing | Improves | -1.76 |
Autonomic: Heart rate increase after standing | Improves | -3.05 |
Autonomic: Inability to tolerate an upright position | Worsen | 1.96 |
Autonomic: Irregular heartbeats | Worsen | 0 |
Autonomic: Shortness of breath | Improves | -3.14 |
Blood Type: A Positive | Improves | -1.28 |
Blood Type: O Positive | Worsen | 2.69 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.98 |
Comorbid-Mouth: Dry Mouth | Worsen | 2.77 |
Comorbid-Mouth: Mouth Sores | Improves | -2.45 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -2.21 |
Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.06 |
Comorbid: Fibromyalgia | Improves | -3.31 |
Comorbid: High Anxiety | Worsen | 3.37 |
Comorbid: Histamine or Mast Cell issues | Worsen | 1.15 |
Comorbid: Hypothyroidism | Worsen | 2.7 |
Comorbid: Inflammatory bowel disease | Improves | -2.63 |
Comorbid: Migraine | Worsen | 1.58 |
Comorbid: Mold Sensitivity / Exposure | Improves | -3.05 |
Comorbid: Multiple Chemical Sensitivity | Worsen | 3.64 |
Comorbid: Restless Leg | Improves | -2.63 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 2.34 |
Condition: ME/CFS with IBS | Worsen | 2.76 |
DePaul University Fatigue Questionnaire : Allergies | Improves | -1.72 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.56 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Improves | -1.72 |
DePaul University Fatigue Questionnaire : Fatigue | Worsen | 0.31 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.61 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.53 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -2.08 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -1.13 |
General: Depression | Improves | -2.31 |
General: Fatigue | Worsen | 1.7 |
General: Headaches | Worsen | 0.92 |
General: Myalgia (pain) | Improves | -3.02 |
General: Sinus issues with headaches | Worsen | 3.21 |
Immune Manifestations: Abdominal Pain | Worsen | 1.88 |
Immune Manifestations: Alcohol Intolerant | Worsen | 2.23 |
Immune Manifestations: Bloating | Worsen | 3.41 |
Immune Manifestations: Constipation | Improves | -2.3 |
Immune Manifestations: Diarrhea | Improves | -1.93 |
Immune Manifestations: general malaise | Worsen | 2.46 |
Immune Manifestations: Hair loss | Worsen | 2.52 |
Immune Manifestations: Inflammation (General) | Improves | -3.24 |
Immune Manifestations: medication sensitivities. | Improves | -3.46 |
Immune Manifestations: Mucus in the stool | Improves | -1.26 |
Immune Manifestations: tender lymph nodes | Worsen | 3.57 |
Immune: Chronic Sinusitis | Worsen | 2.95 |
Immune: Sensitivity to smell/food/medication/chemicals | Worsen | 3.03 |
Immune: Tender / sore lymph nodes | Improves | -0.3 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 4.05 |
Infection: Mycoplasma | Worsen | 2.75 |
Infection: Parasite - Other | Worsen | 2.91 |
Joint: Redness | Improves | -2.82 |
Joint: Stiffness and swelling | Worsen | 2.16 |
Joint: Tenderness | Improves | -3.51 |
Neurocognitive: Absent-mindedness or forgetfulness | Worsen | 3.03 |
Neurocognitive: Brain Fog | Worsen | 2.95 |
Neurocognitive: Can only focus on one thing at a time | Worsen | 3.54 |
Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 3.03 |
Neurocognitive: Slowness of thought | Worsen | 3.03 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.94 |
Neuroendocrine Manifestations: Air Hunger | Improves | -2.91 |
Neuroendocrine Manifestations: cold extremities | Worsen | 3.03 |
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -3.52 |
Neuroendocrine Manifestations: Excessive adrenaline | Improves | -3.75 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 3.66 |
Neuroendocrine Manifestations: Muscle weakness | Worsen | 3.55 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 0 |
Neuroendocrine Manifestations: Rapid muscular fatiguability | Improves | -2.55 |
Neuroendocrine Manifestations: recurrent feelings of feverishness | Improves | -2.79 |
Neuroendocrine Manifestations: subnormal body temperature | Worsen | 2.85 |
Neuroendocrine Manifestations: sweating episodes | Improves | -3.4 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.54 |
Neuroendocrine: Alcohol intolerance | Worsen | 2.83 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -2.31 |
Neuroendocrine: Feeling hot or cold for no reason | Worsen | 1.9 |
Neuroendocrine: Lack of appetite | Worsen | 3.03 |
Neuroendocrine: Lost or gained weight without trying | Improves | -2.23 |
Neurological-Audio: hypersensitivity to noise | Worsen | 1.48 |
Neurological-Audio: Tinnitus (ringing in ear) | Improves | -3.27 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.98 |
Neurological-Sleep: Insomnia | Improves | -2.92 |
Neurological-Sleep: Night Sweats | Improves | -3.73 |
Neurological-Sleep: Sleep Apnea | Worsen | 1.92 |
Neurological-Vision: Blurred Vision | Worsen | 3.17 |
Neurological-Vision: inability to focus eye/vision | Improves | -1.89 |
Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 3.18 |
Neurological: Cognitive/Sensory Overload | Improves | -3.04 |
Neurological: Difficulty processing information (Understanding) | Improves | -3.05 |
Neurological: Difficulty reading | Worsen | 3.94 |
Neurological: emotional overload | Improves | -3.56 |
Neurological: Executive Decision Making (Difficulty making) | Improves | -2.67 |
Neurological: fasciculations | Worsen | 3.7 |
Neurological: Impairment of concentration | Worsen | 2.75 |
Neurological: Joint hypermobility | Improves | -1.21 |
Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.38 |
Neurological: Short-term memory issues | Improves | -3.93 |
Neurological: Slowed speech | Improves | -1.61 |
Neurological: Word-finding problems | Worsen | 1.79 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.98 |
Official Diagnosis: Autoimmune Disease | Improves | -2.67 |
Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.92 |
Official Diagnosis: Mast Cell Dysfunction | Improves | -2.17 |
Onset: 2000-2010 | Worsen | 3.03 |
Onset: 2010-2020 | Worsen | 1.88 |
Onset: Gradual | Worsen | 2.69 |
Onset: less than 16 years since onset | Improves | -2.85 |
Other: Sensitivity to mold | Improves | -2.23 |
Other: Sensitivity to vibrations | Improves | -2.74 |
Pain: Chest pain | Worsen | 2.96 |
Pain: Eye pain | Worsen | 2.92 |
Pain: Sensitivity to pain | Worsen | 3.72 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.8 |
Post-exertional malaise: General | Improves | -3.28 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 2.6 |
Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 3.03 |
Post-exertional malaise: Post-exertional malaise | Improves | -2.63 |
Post-exertional malaise: Rapid cognitive fatigability, | Improves | -2.9 |
Post-exertional malaise: Rapid muscular fatigability, | Worsen | 1.63 |
Sleep: Need to nap daily | Worsen | 2.52 |
Sleep: Problems staying asleep | Improves | -2.67 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.91 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Improves | -4 |
ADHD | Worsen | 4.77 |
Allergies | Worsen | 4.27 |
Alzheimer's disease | Improves | -4.67 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.48 |
Ankylosing spondylitis | Improves | -5.32 |
Asthma | Worsen | 0.99 |
Atherosclerosis | Improves | -5.9 |
Autism | Improves | -4.94 |
Barrett esophagus cancer | Improves | -3 |
Brain Trauma | Improves | -3.08 |
Carcinoma | Improves | -2.2 |
Celiac Disease | Worsen | 3.22 |
Chronic Fatigue Syndrome | Improves | -5.74 |
Chronic Kidney Disease | Worsen | 3.43 |
Chronic urticaria (Hives) | Improves | -3.71 |
Colorectal Cancer | Worsen | 5.9 |
Coronary artery disease | Improves | -4.09 |
Crohn's Disease | Improves | -0.04 |
cystic fibrosis | Improves | -1.9 |
Depression | Worsen | 4.46 |
Epilepsy | Improves | -2.55 |
Fibromyalgia | Improves | -4 |
Functional constipation / chronic idiopathic constipation | Worsen | 2.86 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 3.35 |
Generalized anxiety disorder | Improves | -3.57 |
Gout | Worsen | 3.26 |
Graves' disease | Improves | -3.48 |
Hashimoto's thyroiditis | Worsen | 2.77 |
High Blood Pressure | Improves | -3.54 |
Histamine Issues | Worsen | 2.89 |
Histamine Issues From Ubiome | Improves | -2.96 |
hypercholesterolemia (High Cholesterol) | Worsen | 1.03 |
Hyperlipidemia (High Blood Fats) | Improves | -4.13 |
hypertension (High Blood Pressure | Worsen | 3.3 |
IgA nephropathy (IgAN) | Improves | -4.01 |
Inflammatory Bowel Disease | Improves | -5.27 |
Insomnia | Worsen | 4.38 |
Irritable Bowel Syndrome | Improves | -5.38 |
Juvenile idiopathic arthritis | Worsen | 2.99 |
Liver Cirrhosis | Improves | -6.39 |
ME/CFS with IBS | Improves | -4.99 |
ME/CFS without IBS | Improves | -4.86 |
Metabolic Syndrome | Improves | -1.11 |
Mood Disorders | Worsen | 2.84 |
Multiple Sclerosis | Improves | -4.41 |
Multiple system atrophy (MSA) | Improves | -4.54 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -3.7 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.82 |
Obesity | Worsen | 4.66 |
Osteoporosis | Improves | -3.79 |
Parkinson's Disease | Worsen | 4.42 |
Psoriasis | Improves | -4.41 |
Rheumatoid arthritis | Worsen | 4.64 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -2.71 |
Rosacea | Worsen | 4.29 |
Schizophrenia | Worsen | 4.27 |
Sclerosis | Improves | -2.49 |
Sjögren syndrome | Improves | -4.21 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -4.13 |
Stress / posttraumatic stress disorder | Worsen | 3.56 |
Systemic Lupus Erythematosus | Improves | -3.63 |
Type 1 Diabetes | Improves | -1.97 |
Type 2 Diabetes | Worsen | 3.29 |
Ulcerative colitis | Improves | -4.2 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.