We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 0-10 | Worsen | 3.64 |
Age: 20-30 | Worsen | 3.4 |
Age: 50-60 | Improves | -0.35 |
Age: 60-70 | Improves | -1.23 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.82 |
Asymptomatic: No Health Issues | Worsen | 0.16 |
Autism: Official Diagnosis | Worsen | 3.27 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 3.5 |
Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -3.69 |
Autonomic Manifestations: Orthostatic intolerance | Improves | -2.95 |
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Improves | -3.34 |
Autonomic: Heart rate increase after standing | Improves | -2.92 |
Autonomic: Inability to tolerate an upright position | Worsen | 3.31 |
Autonomic: Shortness of breath | Improves | -2.73 |
Blood Type: A Positive | Improves | -3.55 |
Blood Type: O Positive | Worsen | 3.96 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.51 |
Comorbid-Mouth: Dry Mouth | Improves | -1.76 |
Comorbid-Mouth: Gingivits / Gum Disease | Worsen | 2.19 |
Comorbid-Mouth: Mouth Sores | Improves | -2.73 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -3.56 |
Comorbid: Constipation and Diarrohea (not explosions) | Improves | -2.77 |
Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.61 |
Comorbid: Fibromyalgia | Improves | -2.82 |
Comorbid: High Anxiety | Improves | -3.03 |
Comorbid: Histamine or Mast Cell issues | Improves | -2.82 |
Comorbid: Hypothyroidism | Improves | -2.85 |
Comorbid: Inflammatory bowel disease | Worsen | 3.45 |
Comorbid: Migraine | Worsen | 3.12 |
Comorbid: Restless Leg | Improves | -2.89 |
Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.23 |
Condition: ME/CFS with IBS | Improves | -2.8 |
DePaul University Fatigue Questionnaire : Abdomen pain | Improves | -2.8 |
DePaul University Fatigue Questionnaire : Allergies | Improves | -2.18 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Improves | -1.53 |
DePaul University Fatigue Questionnaire : Depression | Improves | -2.44 |
DePaul University Fatigue Questionnaire : Difficulty falling asleep | Worsen | 2.87 |
DePaul University Fatigue Questionnaire : Difficulty finding the right word | Improves | -2.23 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 2.83 |
DePaul University Fatigue Questionnaire : Fatigue | Worsen | 4.01 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Improves | -3.06 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 4.1 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.68 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 1.42 |
General: Depression | Improves | -2.85 |
General: Headaches | Improves | -1.62 |
General: Myalgia (pain) | Improves | -3.33 |
General: Sinus issues with headaches | Worsen | 1.53 |
Immune Manifestations: Alcohol Intolerant | Improves | -3.06 |
Immune Manifestations: Inflammation (General) | Worsen | 4.24 |
Immune Manifestations: medication sensitivities. | Improves | -3.58 |
Immune Manifestations: Mucus in the stool | Worsen | 3.55 |
Immune: Recurrent Sore throat | Improves | -2.72 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 2.81 |
Infection: Mycoplasma | Worsen | 2.82 |
Infection: Parasite - Other | Worsen | 3.46 |
Joint: Redness | Improves | -2.82 |
Joint: Stiffness and swelling | Improves | -1.7 |
Joint: Sudden and severe episodes of pain | Improves | -1.85 |
Joint: Tenderness | Worsen | 3.34 |
Neurocognitive: Brain Fog | Improves | -2.85 |
Neurocognitive: Can only focus on one thing at a time | Improves | -1.7 |
Neurocognitive: Difficulty expressing thoughts | Worsen | 1.2 |
Neurocognitive: Problems remembering things | Improves | -2.85 |
Neurocognitive: Slowness of thought | Worsen | 2.48 |
Neuroendocrine Manifestations: Excessive adrenaline | Improves | -3.23 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
Neuroendocrine Manifestations: loss of adaptability | Worsen | 2.84 |
Neuroendocrine Manifestations: Muscle weakness | Improves | -2.75 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.24 |
Neuroendocrine Manifestations: Rapid muscular fatiguability | Improves | -2.73 |
Neuroendocrine Manifestations: recurrent feelings of feverishness | Improves | -2.75 |
Neuroendocrine: Alcohol intolerance | Improves | -3.08 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 3.41 |
Neuroendocrine: Feeling hot or cold for no reason | Improves | -3.01 |
Neuroendocrine: Feeling like you have a high temperature | Improves | -3.14 |
Neuroendocrine: Lack of appetite | Worsen | 2.53 |
Neurological-Audio: hypersensitivity to noise | Improves | -2.85 |
Neurological-Audio: Tinnitus (ringing in ear) | Improves | -3.08 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.6 |
Neurological-Sleep: Night Sweats | Improves | -2.73 |
Neurological-Vision: Blurred Vision | Improves | -3.33 |
Neurological-Vision: inability to focus eye/vision | Improves | -2.51 |
Neurological-Vision: photophobia (Light Sensitivity) | Improves | -3.43 |
Neurological: Cognitive/Sensory Overload | Improves | -2.73 |
Neurological: Confusion | Improves | -1.89 |
Neurological: Difficulty processing information (Understanding) | Worsen | 3.09 |
Neurological: Difficulty reading | Improves | -2.85 |
Neurological: emotional overload | Worsen | 2.42 |
Neurological: High degree of Empathy before onset | Improves | -2.75 |
Neurological: Impairment of concentration | Improves | -2.58 |
Neurological: Joint hypermobility | Worsen | 3.11 |
Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.36 |
Neurological: Short-term memory issues | Improves | -2.51 |
Neurological: Slowed speech | Improves | -2.88 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -1.75 |
Official Diagnosis: Autoimmune Disease | Worsen | 3.11 |
Official Diagnosis: Chronic Fatigue Syndrome | Worsen | 1.73 |
Official Diagnosis: Irritable Bowel Syndrome | Worsen | 2.92 |
Official Diagnosis: Mast Cell Dysfunction | Improves | -4 |
Onset: Gradual | Worsen | 3.66 |
Other: Sensitivity to mold | Improves | -1.76 |
Other: Sensitivity to vibrations | Worsen | 1.73 |
Pain: Aching of the eyes or behind the eyes | Improves | -2.73 |
Pain: Myofascial pain | Improves | -2.73 |
Pain: Sensitivity to pain | Worsen | 2.96 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Improves | -2.68 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 1.73 |
Sleep: Problems staying asleep | Improves | -1.7 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Worsen | 2.83 |
ADHD | Worsen | 4.09 |
Allergic Rhinitis (Hay Fever) | Improves | -2.82 |
Allergies | Worsen | 4.3 |
Alzheimer's disease | Improves | -4.72 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.53 |
Ankylosing spondylitis | Improves | -5.8 |
Asthma | Worsen | 2.99 |
Atherosclerosis | Improves | -5.73 |
Autism | Worsen | 4.92 |
Barrett esophagus cancer | Worsen | 3.76 |
Bipolar Disorder | Improves | -3.36 |
Brain Trauma | Worsen | 3.7 |
Carcinoma | Improves | -2.83 |
Celiac Disease | Worsen | 3.07 |
Cerebral Palsy | Improves | -3.41 |
Chronic Fatigue Syndrome | Worsen | 3.23 |
Chronic Kidney Disease | Worsen | 2.36 |
Chronic Urticaria (Hives) | Improves | -4.14 |
Colorectal Cancer | Worsen | 5.81 |
Coronary artery disease | Improves | -2.78 |
COVID-19 | Improves | -4.04 |
Crohn's Disease | Improves | -3.65 |
Depression | Improves | -2.42 |
Eczema | Worsen | 4.08 |
Epilepsy | Improves | -1.02 |
Fibromyalgia | Improves | -3.09 |
Functional constipation / chronic idiopathic constipation | Worsen | 0.56 |
gallstone disease (gsd) | Improves | -3.39 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.49 |
Graves' disease | Worsen | 2.88 |
Hashimoto's thyroiditis | Worsen | 3.31 |
High Blood Pressure | Worsen | 1.39 |
Histamine Issues | Improves | -2.1 |
Histamine Issues From Ubiome | Worsen | 2.42 |
Hyperlipidemia (High Blood Fats) | Worsen | 3.34 |
hypertension (High Blood Pressure | Improves | -1.79 |
IgA nephropathy (IgAN) | Improves | -3.53 |
Inflammatory Bowel Disease | Improves | -4.55 |
Irritable Bowel Syndrome | Worsen | 1.49 |
Liver Cirrhosis | Improves | -5.86 |
ME/CFS with IBS | Improves | -3.5 |
ME/CFS without IBS | Improves | -2.3 |
Multiple Sclerosis | Improves | -4.58 |
Multiple system atrophy (MSA) | Improves | -3.69 |
neuropsychiatric disorders (PANDAS, PANS) | Worsen | 2.63 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.74 |
NonCeliac Gluten Sensitivity | Improves | -1.67 |
Obesity | Improves | -4.12 |
Osteoarthritis | Improves | -2.83 |
Osteoporosis | Improves | -3.99 |
Parkinson's Disease | Worsen | 3.82 |
Psoriasis | Improves | -4.43 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.48 |
Rosacea | Worsen | 3.05 |
Schizophrenia | Worsen | 2.67 |
Sjögren syndrome | Improves | -4.5 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.33 |
Stress / posttraumatic stress disorder | Improves | -4.14 |
Systemic Lupus Erythematosus | Worsen | 2.2 |
Type 1 Diabetes | Worsen | 4.78 |
Type 2 Diabetes | Improves | -3.73 |
Ulcerative colitis | Improves | -4.91 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.