We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.81 |
| Age: 50-60 | Improves | -0.35 |
| Age: 60-70 | Improves | -0.63 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.43 |
| Asymptomatic: No Health Issues | Improves | -1.31 |
| Autism: Official Diagnosis | Worsen | 1.95 |
| Autonomic Manifestations: cardiac arrhythmias | Worsen | 3.5 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -3.05 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -3.09 |
| Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Improves | -2.63 |
| Autonomic: Heart rate increase after standing | Improves | -2.92 |
| Autonomic: Inability to tolerate an upright position | Worsen | 3.69 |
| Autonomic: Shortness of breath | Improves | -2.73 |
| Blood Type: A Positive | Improves | -1.28 |
| Blood Type: O Positive | Worsen | 3.51 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.85 |
| Comorbid-Mouth: Dry Mouth | Improves | -1.76 |
| Comorbid-Mouth: Mouth Sores | Worsen | 2.48 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -2.85 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.15 |
| Comorbid: High Anxiety | Improves | -2.47 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 1.98 |
| Comorbid: Inflammatory bowel disease | Worsen | 3.51 |
| Comorbid: Migraine | Worsen | 2.47 |
| Comorbid: Mold Sensitivity / Exposure | Improves | -3.05 |
| Comorbid: Restless Leg | Improves | -2.89 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.33 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.91 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 1.12 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 2.74 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.52 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 0.81 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.9 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 2.9 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.86 |
| General: Fatigue | Improves | -1.79 |
| General: Headaches | Improves | -1.62 |
| General: Heavy feeling in arms and legs | Worsen | 2.88 |
| General: Myalgia (pain) | Improves | -3.93 |
| General: Sinus issues with headaches | Improves | -1.56 |
| Immune Manifestations: Abdominal Pain | Improves | -1.09 |
| Immune Manifestations: Diarrhea | Worsen | 1.93 |
| Immune Manifestations: Inflammation (General) | Worsen | 4.24 |
| Immune Manifestations: medication sensitivities. | Improves | -3.58 |
| Immune Manifestations: Mucus in the stool | Worsen | 2.92 |
| Immune: Recurrent Sore throat | Improves | -1.24 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 2.92 |
| Infection: Mycoplasma | Worsen | 2.82 |
| Infection: Parasite - Other | Worsen | 2.66 |
| Joint: Redness | Improves | -2.82 |
| Joint: Stiffness and swelling | Improves | -1.7 |
| Joint: Sudden and severe episodes of pain | Improves | -1.85 |
| Joint: Tenderness | Worsen | 2.28 |
| Neurocognitive: Difficulty expressing thoughts | Worsen | 1.2 |
| Neurocognitive: Slowness of thought | Worsen | 2.48 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -2.82 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -3.23 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -2.75 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.17 |
| Neuroendocrine Manifestations: Rapid muscular fatiguability | Improves | -2.73 |
| Neuroendocrine Manifestations: recurrent feelings of feverishness | Improves | -2.75 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 2.48 |
| Neuroendocrine: Alcohol intolerance | Improves | -3.08 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 3.54 |
| Neuroendocrine: Feeling hot or cold for no reason | Improves | -2.72 |
| Neuroendocrine: Feeling like you have a high temperature | Improves | -2.89 |
| Neuroendocrine: Lack of appetite | Worsen | 0.38 |
| Neuroendocrine: Sweating hands | Improves | -0.96 |
| Neurological-Audio: hypersensitivity to noise | Improves | -2.85 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -2.85 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 0.54 |
| Neurological-Sleep: Night Sweats | Improves | -2.73 |
| Neurological-Vision: Blurred Vision | Improves | -3.33 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.85 |
| Neurological: Cognitive/Sensory Overload | Improves | -2.97 |
| Neurological: Difficulty processing information (Understanding) | Improves | -3.05 |
| Neurological: emotional overload | Improves | -2.13 |
| Neurological: High degree of Empathy before onset | Improves | -2.75 |
| Neurological: Impairment of concentration | Improves | -3.05 |
| Neurological: Joint hypermobility | Worsen | 1.81 |
| Neurological: Short-term memory issues | Improves | -2.9 |
| Neurological: Slowed speech | Improves | -1.61 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -1.75 |
| Official Diagnosis: Autoimmune Disease | Worsen | 2.97 |
| Official Diagnosis: Chronic Fatigue Syndrome | Worsen | 1.73 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 3.16 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -4.05 |
| Onset: Gradual | Worsen | 3.49 |
| Onset: less than 16 years since onset | Improves | -2.85 |
| Other: Sensitivity to mold | Improves | -1.76 |
| Other: Sensitivity to vibrations | Worsen | 1.73 |
| Pain: Aching of the eyes or behind the eyes | Worsen | 2.63 |
| Pain: Eye pain | Worsen | 3.56 |
| Pain: Myofascial pain | Worsen | 1.73 |
| Pain: Sensitivity to pain | Worsen | 2.96 |
| Post-exertional malaise: General | Improves | -2.61 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 1.73 |
| Post-exertional malaise: Physically drained or sick after mild activity | Improves | -3.05 |
| Post-exertional malaise: Rapid cognitive fatigability, | Improves | -3.05 |
| Sleep: Need to nap daily | Worsen | 2.82 |
| Sleep: Problems staying asleep | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 2.72 |
| ADHD | Improves | -3.39 |
| Allergies | Worsen | 3.67 |
| Alzheimer's disease | Improves | -3.37 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.59 |
| Ankylosing spondylitis | Improves | -5.85 |
| Asthma | Improves | -2.79 |
| Atherosclerosis | Improves | -5.73 |
| Autism | Worsen | 4.77 |
| Barrett esophagus cancer | Worsen | 3.76 |
| Brain Trauma | Worsen | 2.73 |
| Carcinoma | Improves | -2.83 |
| Celiac Disease | Worsen | 2.33 |
| Chronic Fatigue Syndrome | Worsen | 3.23 |
| Chronic Kidney Disease | Worsen | 2.36 |
| Chronic urticaria (Hives) | Improves | -4.14 |
| Colorectal Cancer | Worsen | 5.81 |
| Coronary artery disease | Improves | -2.78 |
| Crohn's Disease | Improves | -3.65 |
| Depression | Improves | -2.42 |
| Epilepsy | Improves | -1.02 |
| Fibromyalgia | Improves | -1.47 |
| Functional constipation / chronic idiopathic constipation | Worsen | 3.46 |
| gallstone disease (gsd) | Improves | -3.39 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.49 |
| Graves' disease | Worsen | 2.88 |
| Hashimoto's thyroiditis | Worsen | 3.31 |
| High Blood Pressure | Worsen | 1.39 |
| Histamine Issues | Improves | -2.1 |
| Histamine Issues From Ubiome | Worsen | 2.42 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.34 |
| IgA nephropathy (IgAN) | Improves | -3.53 |
| Inflammatory Bowel Disease | Improves | -4.48 |
| Irritable Bowel Syndrome | Worsen | 1.49 |
| Liver Cirrhosis | Improves | -5.86 |
| ME/CFS with IBS | Improves | -3.5 |
| ME/CFS without IBS | Improves | -2.3 |
| Multiple Sclerosis | Improves | -4.05 |
| Multiple system atrophy (MSA) | Improves | -3.69 |
| neuropsychiatric disorders (PANDAS, PANS) | Worsen | 2.63 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -1.24 |
| Obesity | Improves | -4.07 |
| Osteoporosis | Improves | -3.99 |
| Parkinson's Disease | Improves | -0.9 |
| Psoriasis | Improves | -2.94 |
| Rheumatoid arthritis | Worsen | 2.39 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.26 |
| Rosacea | Worsen | 3.05 |
| Schizophrenia | Improves | -3.38 |
| Sjögren syndrome | Improves | -3.76 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.33 |
| Stress / posttraumatic stress disorder | Improves | -4.14 |
| Systemic Lupus Erythematosus | Worsen | 4.08 |
| Type 1 Diabetes | Worsen | 4.42 |
| Type 2 Diabetes | Worsen | 0.71 |
| Ulcerative colitis | Improves | -4.4 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.