trimethoprim (antibiotic)s ** full range

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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 0-10	Improves	-3.56
Condition: ME/CFS with IBS	Worsen	2.8
DePaul University Fatigue Questionnaire : Abdomen pain	Worsen	2.8
DePaul University Fatigue Questionnaire : Allergies	Worsen	2.8
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	2.8
DePaul University Fatigue Questionnaire : Depression	Worsen	2.8
DePaul University Fatigue Questionnaire : Difficulty finding the right word	Worsen	2.8
DePaul University Fatigue Questionnaire : Difficulty staying asleep	Improves	-2.83
DePaul University Fatigue Questionnaire : Fatigue	Worsen	2.8
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	2.8
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	2.8
Neuroendocrine: Feeling like you have a low temperature	Improves	-2.74
Neurological: emotional overload	Improves	-2.74
Neurological: Executive Decision Making (Difficulty making)	Worsen	2.42
Neurological: fasciculations	Improves	-2.74
Neurological: High degree of Empathy before onset	Improves	-2.74
Neurological: Impairment of concentration	Worsen	2.42
Neurological: Short-term memory issues	Improves	-2.74
Neurological: Spatial instability and disorientation	Improves	-2.74
Onset: less than 02 years since onset	Improves	-2.74
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	3.56
Post-exertional malaise: Worsening of symptoms after mild mental activity	Improves	-2.74

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-4.35
ADHD	Worsen	4.27
Allergic Rhinitis (Hay Fever)	Improves	-3.33
Allergies	Improves	-4.2
Alzheimer's disease	Worsen	4.06
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	0.92
Ankylosing spondylitis	Worsen	3.46
Asthma	Improves	-2.82
Atherosclerosis	Improves	-2.41
Autism	Improves	-3.77
Barrett esophagus cancer	Worsen	1.46
Bipolar Disorder	Improves	-2.84
Brain Trauma	Worsen	2.87
Carcinoma	Improves	-3.18
Celiac Disease	Improves	-4.08
Cerebral Palsy	Worsen	2.88
Chronic Fatigue Syndrome	Improves	-4.77
Chronic Kidney Disease	Improves	-3.14
Chronic Lyme	Worsen	2.74
Chronic Urticaria (Hives)	Improves	-1.68
Colorectal Cancer	Improves	-4.28
COVID-19	Improves	-1.24
Crohn's Disease	Worsen	1.1
cystic fibrosis	Improves	-3.97
Depression	Worsen	4.03
Epilepsy	Improves	-3.47
Fibromyalgia	Improves	-3.89
Functional constipation / chronic idiopathic constipation	Worsen	1.62
gallstone disease (gsd)	Improves	-0.86
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-1.46
Generalized anxiety disorder	Improves	-3.37
Graves' disease	Improves	-2.74
Hashimoto's thyroiditis	Improves	-3.77
High Blood Pressure	Improves	-2.43
Histamine Issues	Improves	-4.2
Histamine Issues From Ubiome	Improves	-2.72
Hyperlipidemia (High Blood Fats)	Improves	-2.63
IgA nephropathy (IgAN)	Improves	-2.86
Inflammatory Bowel Disease	Improves	-4.02
Irritable Bowel Syndrome	Improves	-4.2
Liver Cirrhosis	Improves	-4.74
ME/CFS with IBS	Improves	-2.88
ME/CFS without IBS	Improves	-2.67
Mood Disorders	Worsen	2.74
Multiple Sclerosis	Worsen	2.81
Multiple system atrophy (MSA)	Improves	-1.3
neuropsychiatric disorders (PANDAS, PANS)	Improves	-2.42
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-1.65
NonCeliac Gluten Sensitivity	Improves	-2.88
Obesity	Improves	-3.19
Osteoarthritis	Improves	-2.41
Osteoporosis	Worsen	1.63
Parkinson's Disease	Worsen	5.73
Psoriasis	Worsen	2.67
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-4.92
Rosacea	Worsen	1.97
Schizophrenia	Improves	-3.25
Sjögren syndrome	Improves	-4.08
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-4.26
Stress / posttraumatic stress disorder	Improves	-3.08
Systemic Lupus Erythematosus	Improves	-4.1
Type 1 Diabetes	Improves	-3.87
Type 2 Diabetes	Improves	-3.36
Ulcerative colitis	Improves	-4.36

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.