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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Comorbid-Mouth: Dry Mouth	Improves	-2.74
DePaul University Fatigue Questionnaire : Allergies	Worsen	2.8
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	2.8
DePaul University Fatigue Questionnaire : Fatigue	Worsen	2.8
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	2.8
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	2.8
Neuroendocrine: Feeling like you have a low temperature	Improves	-2.74
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Improves	-2.83
Neurological: emotional overload	Improves	-2.74
Neurological: fasciculations	Improves	-2.74
Neurological: High degree of Empathy before onset	Improves	-2.74
Neurological: Short-term memory issues	Improves	-2.74
Neurological: Spatial instability and disorientation	Improves	-2.74
Post-exertional malaise: General	Improves	-2.74
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	1.2
Post-exertional malaise: Physically drained or sick after mild activity	Improves	-2.74
Post-exertional malaise: Post-exertional malaise	Improves	-2.74
Post-exertional malaise: Rapid cognitive fatigability,	Improves	-2.74
Post-exertional malaise: Worsening of symptoms after mild mental activity	Improves	-2.74

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-3.47
ADHD	Worsen	3.56
Allergies	Improves	-3.53
Alzheimer's disease	Improves	-3.56
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Improves	-3.45
Ankylosing spondylitis	Worsen	3.83
Asthma	Worsen	1.2
Atherosclerosis	Improves	-2.41
Autism	Improves	-4.59
Barrett esophagus cancer	Worsen	1.46
Brain Trauma	Worsen	3.04
Carcinoma	Improves	-3.18
Celiac Disease	Improves	-3.24
Chronic Fatigue Syndrome	Improves	-4.77
Chronic Kidney Disease	Improves	-3.14
Chronic urticaria (Hives)	Improves	-1.68
Colorectal Cancer	Improves	-4.28
Crohn's Disease	Worsen	1.1
cystic fibrosis	Improves	-3.97
Depression	Worsen	4.03
Epilepsy	Improves	-3.47
Fibromyalgia	Improves	-3.47
Functional constipation / chronic idiopathic constipation	Improves	-2.83
gallstone disease (gsd)	Improves	-0.86
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-1.46
Generalized anxiety disorder	Improves	-3.37
Graves' disease	Improves	-2.74
Hashimoto's thyroiditis	Improves	-3.77
High Blood Pressure	Improves	-2.43
Histamine Issues	Improves	-4.2
Histamine Issues From Ubiome	Improves	-2.72
Hyperlipidemia (High Blood Fats)	Improves	-2.63
IgA nephropathy (IgAN)	Improves	-2.86
Inflammatory Bowel Disease	Improves	-3.81
Irritable Bowel Syndrome	Improves	-4.2
Liver Cirrhosis	Improves	-4.74
ME/CFS with IBS	Improves	-2.88
ME/CFS without IBS	Improves	-2.67
Mood Disorders	Worsen	2.74
Multiple Sclerosis	Improves	-2.57
Multiple system atrophy (MSA)	Improves	-1.3
neuropsychiatric disorders (PANDAS, PANS)	Improves	-2.42
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-3.05
Obesity	Improves	-2.44
Osteoporosis	Worsen	1.63
Parkinson's Disease	Worsen	4.86
Psoriasis	Improves	-2.92
Rheumatoid arthritis	Improves	-4.59
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-2.24
Rosacea	Worsen	1.97
Schizophrenia	Worsen	3.46
Sjögren syndrome	Improves	-3.33
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-4.26
Stress / posttraumatic stress disorder	Improves	-2.46
Systemic Lupus Erythematosus	Improves	-4.09
Type 1 Diabetes	Improves	-3.01
Type 2 Diabetes	Worsen	2.55
Ulcerative colitis	Improves	-3.19

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.