We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 20-30 | Worsen | 3.29 |
Age: 30-40 | Improves | -2.54 |
Age: 50-60 | Worsen | 2.22 |
Age: 60-70 | Worsen | 4.08 |
Asymptomatic: Live in house with person with probable microbiome dysfunction | Worsen | 2.38 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -3.9 |
Asymptomatic: No Health Issues | Worsen | 2.46 |
Autism: Official Diagnosis | Worsen | 4.5 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 3.5 |
Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -3.45 |
Autonomic Manifestations: irritable bowel syndrome | Improves | -3.87 |
Autonomic Manifestations: Orthostatic intolerance | Worsen | 2.44 |
Autonomic Manifestations: palpitations | Worsen | 0.01 |
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Improves | -2.71 |
Autonomic: Blurred or tunnel vision after standing | Worsen | 2.91 |
Autonomic: Heart rate increase after standing | Improves | -3.13 |
Autonomic: Inability to tolerate an upright position | Worsen | 4.18 |
Autonomic: Irregular heartbeats | Worsen | 3.19 |
Autonomic: Ocassional Tachycardia (Rapid heart beat) | Worsen | 2.78 |
Autonomic: Shortness of breath | Improves | -1.1 |
Blood Type: A Positive | Worsen | 3.94 |
Blood Type: O Positive | Worsen | 4.86 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 3.71 |
Comorbid-Mouth: Dry Mouth | Improves | -1.09 |
Comorbid-Mouth: Mouth Sores | Improves | -1.95 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 4.7 |
Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 4.94 |
Comorbid: Fibromyalgia | Worsen | 2.29 |
Comorbid: High Anxiety | Worsen | 4.53 |
Comorbid: Histamine or Mast Cell issues | Worsen | 4.43 |
Comorbid: Hypothyroidism | Worsen | 4.2 |
Comorbid: Inflammatory bowel disease | Worsen | 4.39 |
Comorbid: Migraine | Worsen | 3.62 |
Comorbid: Mold Sensitivity / Exposure | Improves | -3.13 |
Comorbid: Multiple Chemical Sensitivity | Worsen | 2.64 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 4.58 |
Condition: ME/CFS with IBS | Worsen | 3.56 |
DePaul University Fatigue Questionnaire : Allergies | Worsen | 4.44 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.18 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 4.33 |
DePaul University Fatigue Questionnaire : Fatigue | Worsen | 5.17 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.82 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 5.15 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 5.31 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.69 |
Gender: Male | Worsen | 1.27 |
General: Depression | Worsen | 1.71 |
General: Fatigue | Improves | -3.29 |
General: Headaches | Worsen | 0.73 |
General: Myalgia (pain) | Improves | -3.85 |
General: Sinus issues with headaches | Worsen | 3.43 |
Immune Manifestations: Abdominal Pain | Worsen | 3.28 |
Immune Manifestations: Alcohol Intolerant | Worsen | 4.24 |
Immune Manifestations: Bloating | Improves | -2.65 |
Immune Manifestations: Constipation | Worsen | 2.17 |
Immune Manifestations: Diarrhea | Worsen | 3.4 |
Immune Manifestations: general malaise | Improves | -3.47 |
Immune Manifestations: Hair loss | Improves | -2.58 |
Immune Manifestations: Inflammation (General) | Worsen | 2.95 |
Immune Manifestations: medication sensitivities. | Improves | -3.13 |
Immune Manifestations: Mucus in the stool | Worsen | 3.34 |
Immune Manifestations: new food sensitivities | Worsen | 2.89 |
Immune Manifestations: tender lymph nodes | Worsen | 0.06 |
Immune: Sensitivity to smell/food/medication/chemicals | Improves | -3.12 |
Infection: Epstein-Barr virus | Worsen | 1.94 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 4 |
Infection: Mycoplasma | Worsen | 3.7 |
Infection: Parasite - Other | Worsen | 2.95 |
Joint: Redness | Worsen | 3.43 |
Joint: Stiffness and swelling | Worsen | 4.59 |
Joint: Tenderness | Worsen | 3.98 |
Neurocognitive: Absent-mindedness or forgetfulness | Improves | -3.12 |
Neurocognitive: Brain Fog | Worsen | 2.95 |
Neurocognitive: Can only focus on one thing at a time | Worsen | 1.99 |
Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 2.7 |
Neurocognitive: Problems remembering things | Worsen | 3.59 |
Neurocognitive: Slowness of thought | Improves | -1.64 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 4.65 |
Neuroendocrine Manifestations: Air Hunger | Improves | -2 |
Neuroendocrine Manifestations: cold extremities | Improves | -3.57 |
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -3.88 |
Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.76 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 3.59 |
Neuroendocrine Manifestations: marked weight change | Improves | -2.35 |
Neuroendocrine Manifestations: Muscle weakness | Worsen | 3.59 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.15 |
Neuroendocrine Manifestations: Rapid muscular fatiguability | Improves | -3.64 |
Neuroendocrine Manifestations: subnormal body temperature | Improves | -2 |
Neuroendocrine Manifestations: sweating episodes | Worsen | 2.75 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Improves | -3.12 |
Neuroendocrine: Alcohol intolerance | Worsen | 4.29 |
Neuroendocrine: Chills or shivers | Worsen | 3.4 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 2.93 |
Neuroendocrine: Feeling hot or cold for no reason | Improves | -2.18 |
Neuroendocrine: Feeling like you have a high temperature | Worsen | 2.71 |
Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
Neuroendocrine: Lack of appetite | Improves | -1.68 |
Neuroendocrine: Lost or gained weight without trying | Worsen | 2.29 |
Neurological-Audio: hypersensitivity to noise | Improves | -1.64 |
Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 3.81 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.2 |
Neurological-Sleep: Insomnia | Worsen | 4.2 |
Neurological-Sleep: Night Sweats | Improves | -3.27 |
Neurological-Sleep: Sleep Apnea | Improves | -3.24 |
Neurological-Sleep: Vivid Dreams/Nightmares | Improves | -2.69 |
Neurological-Vision: Blurred Vision | Improves | -3.16 |
Neurological-Vision: inability to focus eye/vision | Worsen | 4.99 |
Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 4.37 |
Neurological: Cognitive/Sensory Overload | Improves | -3.87 |
Neurological: Difficulty processing information (Understanding) | Improves | -3.26 |
Neurological: Difficulty reading | Worsen | 3.58 |
Neurological: Disorientation | Worsen | 2.95 |
Neurological: Dysautonomia | Worsen | 2.25 |
Neurological: emotional overload | Improves | -3.17 |
Neurological: Executive Decision Making (Difficulty making) | Improves | -2.07 |
Neurological: fasciculations | Improves | -0.5 |
Neurological: High degree of Empathy before onset | Worsen | 2.74 |
Neurological: Impairment of concentration | Improves | -3.59 |
Neurological: Joint hypermobility | Worsen | 4.83 |
Neurological: Seasonal Affective Disorder (SAD) | Worsen | 3.16 |
Neurological: Short-term memory issues | Improves | -3.74 |
Neurological: Spatial instability and disorientation | Worsen | 3.52 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 4.66 |
Official Diagnosis: Autoimmune Disease | Worsen | 4.01 |
Official Diagnosis: Irritable Bowel Syndrome | Worsen | 3.9 |
Official Diagnosis: Mast Cell Dysfunction | Worsen | 4.27 |
Onset: 2000-2010 | Improves | -3.12 |
Onset: 2010-2020 | Worsen | 3.81 |
Onset: Gradual | Improves | -3.6 |
Other: Sensitivity to mold | Worsen | 2.29 |
Other: Sensitivity to vibrations | Improves | -2.82 |
Pain: Eye pain | Worsen | 3 |
Pain: Pain or aching in muscles | Worsen | 2.71 |
Pain: Sensitivity to pain | Worsen | 3.05 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.25 |
Post-exertional malaise: General | Worsen | 2.74 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.48 |
Post-exertional malaise: Physically drained or sick after mild activity | Improves | -2.08 |
Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
Post-exertional malaise: Rapid cognitive fatigability, | Improves | -3.88 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
Sleep: Daytime drowsiness | Worsen | 2.24 |
Sleep: Problems falling asleep | Worsen | 2.71 |
Sleep: Problems staying asleep | Improves | -3.41 |
Sleep: Unrefreshed sleep | Improves | -2.46 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 3.68 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Improves | -3.87 |
ADHD | Worsen | 3.86 |
Allergies | Worsen | 4.37 |
Alzheimer's disease | Worsen | 3.56 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.83 |
Ankylosing spondylitis | Improves | -1.82 |
Asthma | Worsen | 3.15 |
Atherosclerosis | Improves | -5.75 |
Autism | Worsen | 4.58 |
Barrett esophagus cancer | Improves | -0.81 |
Brain Trauma | Worsen | 3.71 |
Carcinoma | Improves | -3.78 |
Celiac Disease | Worsen | 0.04 |
Chronic Fatigue Syndrome | Improves | -5.5 |
Chronic Kidney Disease | Improves | -4.57 |
Chronic urticaria (Hives) | Worsen | 4.33 |
Colorectal Cancer | Worsen | 5.4 |
Coronary artery disease | Improves | -2.57 |
Crohn's Disease | Improves | -5.12 |
cystic fibrosis | Improves | -3.57 |
Depression | Improves | -4.18 |
Epilepsy | Improves | -4.1 |
Fibromyalgia | Worsen | 4.82 |
Functional constipation / chronic idiopathic constipation | Worsen | 3.95 |
gallstone disease (gsd) | Improves | -2.07 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 3.35 |
Generalized anxiety disorder | Improves | -3.31 |
Gout | Worsen | 2.55 |
Graves' disease | Improves | -0.21 |
Hashimoto's thyroiditis | Improves | -3.32 |
High Blood Pressure | Worsen | 3.01 |
Histamine Issues | Improves | -4.19 |
Histamine Issues From Ubiome | Improves | -2.72 |
hypercholesterolemia (High Cholesterol) | Improves | -2.64 |
Hyperlipidemia (High Blood Fats) | Improves | -3.51 |
hypertension (High Blood Pressure | Worsen | 3.68 |
IgA nephropathy (IgAN) | Improves | -4.91 |
Inflammatory Bowel Disease | Improves | -4.53 |
Insomnia | Improves | -3.99 |
Irritable Bowel Syndrome | Improves | -5.67 |
Liver Cirrhosis | Improves | -6.06 |
ME/CFS with IBS | Improves | -4.2 |
ME/CFS without IBS | Improves | -4.29 |
Metabolic Syndrome | Worsen | 2.9 |
Mood Disorders | Worsen | 3.05 |
Multiple Sclerosis | Improves | -5.12 |
Multiple system atrophy (MSA) | Improves | -4.07 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -3.45 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 2.89 |
Obesity | Worsen | 5.28 |
Osteoporosis | Improves | -2.14 |
Parkinson's Disease | Improves | -4.14 |
Psoriasis | Improves | -4.63 |
Rheumatoid arthritis | Improves | -5.24 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.95 |
Rosacea | Improves | -2.78 |
Schizophrenia | Worsen | 3.45 |
Sclerosis | Improves | -3.56 |
Sjögren syndrome | Improves | -3.46 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -4.89 |
Stress / posttraumatic stress disorder | Improves | -4.58 |
Systemic Lupus Erythematosus | Worsen | 2.13 |
Type 1 Diabetes | Improves | -3.47 |
Type 2 Diabetes | Worsen | 5.66 |
Ulcerative colitis | Worsen | 3.3 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.