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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 0-10	Worsen	3.92
Age: 20-30	Worsen	3.29
Age: 50-60	Worsen	2.82
Age: 60-70	Worsen	4.28
Asymptomatic: Live in house with person with probable microbiome dysfunction	Worsen	3.07
Asymptomatic: Minor Health Issues (a few symptoms only)	Improves	-3.9
Asymptomatic: No Health Issues	Worsen	3.01
Autism: Official Diagnosis	Worsen	4.67
Autonomic Manifestations: cardiac arrhythmias	Worsen	3.46
Autonomic Manifestations: Cortisol disorders or irregularity	Improves	-4.2
Autonomic Manifestations: irritable bowel syndrome	Improves	-3.87
Autonomic Manifestations: light-headedness	Improves	-1.67
Autonomic Manifestations: Orthostatic intolerance	Worsen	3.08
Autonomic Manifestations: palpitations	Improves	-3.93
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)	Improves	-2.81
Autonomic Manifestations: urinary frequency dysfunction	Worsen	2.78
Autonomic: Blurred or tunnel vision after standing	Worsen	3.58
Autonomic: Graying or blacking out after standing	Improves	-2.92
Autonomic: Heart rate increase after standing	Improves	-3.13
Autonomic: Inability to tolerate an upright position	Worsen	4.26
Autonomic: Irregular heartbeats	Worsen	2.57
Autonomic: Shortness of breath	Worsen	2.72
Blood Type: A Positive	Worsen	3.43
Blood Type: O Positive	Worsen	5.09
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Worsen	3.92
Comorbid-Mouth: Dry Mouth	Worsen	3.67
Comorbid-Mouth: Mouth Sores	Improves	-3.12
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	Worsen	4.44
Comorbid: Constipation and Diarrohea (not explosions)	Improves	-2.49
Comorbid: Constipation and Explosions (not diarrohea)	Worsen	4.46
Comorbid: Fibromyalgia	Worsen	3.66
Comorbid: High Anxiety	Worsen	4.59
Comorbid: Histamine or Mast Cell issues	Worsen	3.91
Comorbid: Hypothyroidism	Worsen	4.2
Comorbid: Inflammatory bowel disease	Worsen	4.45
Comorbid: Methylation issues (MTHFR)	Worsen	3.01
Comorbid: Migraine	Worsen	3.9
Comorbid: Mold Sensitivity / Exposure	Improves	-2.49
Comorbid: Multiple Chemical Sensitivity	Worsen	3.47
Comorbid: Snoring (NOT Sleep Apnea	Worsen	4.28
DePaul University Fatigue Questionnaire : Abdomen pain	Worsen	2.62
DePaul University Fatigue Questionnaire : Allergies	Worsen	4.28
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	3.85
DePaul University Fatigue Questionnaire : Depression	Worsen	4.15
DePaul University Fatigue Questionnaire : Difficulty falling asleep	Worsen	4.17
DePaul University Fatigue Questionnaire : Difficulty finding the right word	Worsen	3.92
DePaul University Fatigue Questionnaire : Difficulty staying asleep	Worsen	4.63
DePaul University Fatigue Questionnaire : Fatigue	Worsen	5.21
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	4.35
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Worsen	4.84
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Worsen	4.71
DePaul University Fatigue Questionnaire : Upset stomach	Worsen	3.16
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	3.85
Gender: Female	Worsen	2.92
General: Depression	Worsen	1.71
General: Fatigue	Worsen	2.9
General: Headaches	Improves	-1.97
General: Myalgia (pain)	Improves	-3.85
General: Sinus issues with headaches	Worsen	3.26
Immune Manifestations: Abdominal Pain	Worsen	3.66
Immune Manifestations: Alcohol Intolerant	Worsen	3.14
Immune Manifestations: Bloating	Worsen	2.24
Immune Manifestations: Constipation	Worsen	3.85
Immune Manifestations: Diarrhea	Worsen	2.9
Immune Manifestations: general malaise	Improves	-3.47
Immune Manifestations: Hair loss	Improves	-2.58
Immune Manifestations: Inflammation (General)	Worsen	3.63
Immune Manifestations: medication sensitivities.	Improves	-3.41
Immune Manifestations: Mucus in the stool	Worsen	4.05
Immune Manifestations: new food sensitivities	Worsen	1.06
Immune: Recurrent Sore throat	Improves	-3.49
Immune: Sensitivity to smell/food/medication/chemicals	Improves	-3.12
Infection: Epstein-Barr virus	Worsen	1.94
Infection: Human Herpesvirus 6 (HHV6)	Worsen	3.25
Infection: Mycoplasma	Worsen	3.68
Infection: Parasite - Other	Worsen	3.44
Joint: Redness	Worsen	3.43
Joint: Stiffness and swelling	Worsen	4.69
Joint: Tenderness	Worsen	3.44
Neurocognitive: Brain Fog	Worsen	3.62
Neurocognitive: Can only focus on one thing at a time	Worsen	2.09
Neurocognitive: Difficulty paying attention for a long period of time	Worsen	1.99
Neurocognitive: Difficulty understanding things	Improves	-2.33
Neurocognitive: Problems remembering things	Worsen	3.59
Neurocognitive: Slowness of thought	Improves	-3.12
Neurocognitive: Unable to focus vision and/or attention	Worsen	4.34
Neuroendocrine Manifestations: Air Hunger	Improves	-2
Neuroendocrine Manifestations: cold extremities	Improves	-3.54
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)	Improves	-3.44
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-2.76
Neuroendocrine Manifestations: intolerance of extremes of heat and cold	Worsen	3.59
Neuroendocrine Manifestations: loss of adaptability	Worsen	2.93
Neuroendocrine Manifestations: Muscle weakness	Worsen	3.59
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	Worsen	4.34
Neuroendocrine Manifestations: Rapid muscular fatiguability	Improves	-2.81
Neuroendocrine Manifestations: subnormal body temperature	Improves	-2
Neuroendocrine Manifestations: sweating episodes	Worsen	3.07
Neuroendocrine Manifestations: worsening of symptoms with stress.	Improves	-3.28
Neuroendocrine: Alcohol intolerance	Worsen	4.27
Neuroendocrine: Chills or shivers	Worsen	3.4
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	Worsen	1.71
Neuroendocrine: Feeling hot or cold for no reason	Improves	-2.26
Neuroendocrine: Feeling like you have a high temperature	Worsen	1.14
Neuroendocrine: Feeling like you have a low temperature	Worsen	2.74
Neuroendocrine: Lack of appetite	Improves	-1.68
Neuroendocrine: Lost or gained weight without trying	Worsen	2.9
Neurological-Audio: hypersensitivity to noise	Worsen	1.91
Neurological-Audio: Tinnitus (ringing in ear)	Worsen	2.8
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Improves	-3
Neurological-Sleep: Insomnia	Worsen	4.14
Neurological-Sleep: Night Sweats	Improves	-3.27
Neurological-Sleep: Sleep Apnea	Worsen	2.43
Neurological-Sleep: Vivid Dreams/Nightmares	Improves	-3.38
Neurological-Vision: Blurred Vision	Improves	-3.16
Neurological-Vision: inability to focus eye/vision	Worsen	3.99
Neurological-Vision: photophobia (Light Sensitivity)	Worsen	4.31
Neurological: Cognitive/Sensory Overload	Improves	-2.81
Neurological: Difficulty processing information (Understanding)	Improves	-2.17
Neurological: Difficulty reading	Worsen	4.03
Neurological: Disorientation	Improves	-2.96
Neurological: Dysautonomia	Improves	-2.45
Neurological: emotional overload	Improves	-0.71
Neurological: Executive Decision Making (Difficulty making)	Improves	-2.94
Neurological: fasciculations	Improves	-3
Neurological: High degree of Empathy before onset	Worsen	2.74
Neurological: Impairment of concentration	Worsen	2.03
Neurological: Joint hypermobility	Worsen	4.8
Neurological: Neuropathy	Improves	-2.96
Neurological: Seasonal Affective Disorder (SAD)	Worsen	2.82
Neurological: Short-term memory issues	Improves	-2.86
Neurological: Slowed speech	Worsen	2.77
Neurological: Spatial instability and disorientation	Worsen	3.52
Official Diagnosis: Allergic Rhinitis (Hay Fever)	Worsen	4.37
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD)	Improves	-2.84
Official Diagnosis: Autoimmune Disease	Worsen	3.49
Official Diagnosis: Irritable Bowel Syndrome	Worsen	4.49
Official Diagnosis: Mast Cell Dysfunction	Worsen	3.95
Onset: 2010-2020	Worsen	4.18
Onset: Gradual	Improves	-2.91
Onset: less than 02 years since onset	Worsen	2.74
Other: Sensitivity to mold	Improves	-0.83
Pain: Aching of the eyes or behind the eyes	Improves	-2.81
Pain: Chest pain	Improves	-2.56
Pain: Myofascial pain	Improves	-2.81
Pain: Sensitivity to pain	Worsen	2.48
Post-exertional malaise: Difficulty reading after mild physical or mental activity	Improves	-2.3
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	2.88
Post-exertional malaise: Physically drained or sick after mild activity	Improves	-3.12
Post-exertional malaise: Rapid cognitive fatigability,	Improves	-3.71
Post-exertional malaise: Worsening of symptoms after mild mental activity	Worsen	2.74
Sleep: Daytime drowsiness	Worsen	3.62
Sleep: Problems staying asleep	Improves	-2.69
Sleep: Waking up early in the morning (e.g. 3 AM)	Worsen	3.79

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-4.06
ADHD	Worsen	5.47
Allergic Rhinitis (Hay Fever)	Improves	-3.34
Allergies	Worsen	4.93
Alzheimer's disease	Improves	-4.07
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	3.3
Ankylosing spondylitis	Improves	-4.55
Asthma	Worsen	1.9
Atherosclerosis	Improves	-5.85
Autism	Worsen	4.91
Barrett esophagus cancer	Improves	-0.81
Bipolar Disorder	Improves	-2.57
Brain Trauma	Worsen	3.62
Carcinoma	Improves	-3.78
Celiac Disease	Improves	-4.37
Cerebral Palsy	Improves	-3.26
Chronic Fatigue Syndrome	Improves	-5.5
Chronic Kidney Disease	Improves	-4.57
Chronic Lyme	Improves	-3.55
Chronic Urticaria (Hives)	Worsen	4.33
Colorectal Cancer	Worsen	5.4
Coronary artery disease	Improves	-2.57
COVID-19	Improves	-3.79
Crohn's Disease	Improves	-5.12
cystic fibrosis	Improves	-3.57
Depression	Improves	-4.18
Eczema	Improves	-4.15
Epilepsy	Improves	-4.1
Fibromyalgia	Worsen	5.53
Functional constipation / chronic idiopathic constipation	Worsen	1.2
gallstone disease (gsd)	Improves	-2.07
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Worsen	3.35
Generalized anxiety disorder	Improves	-3.31
Gout	Worsen	2.55
Graves' disease	Improves	-0.21
Hashimoto's thyroiditis	Improves	-3.32
High Blood Pressure	Worsen	3.01
Histamine Issues	Improves	-4.19
Histamine Issues From Ubiome	Improves	-2.72
hypercholesterolemia (High Cholesterol)	Improves	-2.64
Hyperlipidemia (High Blood Fats)	Improves	-3.51
hypertension (High Blood Pressure	Worsen	3.97
IgA nephropathy (IgAN)	Improves	-4.91
Inflammatory Bowel Disease	Improves	-5.05
Insomnia	Improves	-3.99
Irritable Bowel Syndrome	Improves	-5.72
Liver Cirrhosis	Improves	-6.06
ME/CFS with IBS	Improves	-4.2
ME/CFS without IBS	Improves	-4.29
Metabolic Syndrome	Worsen	2.9
Mood Disorders	Worsen	3.05
Multiple Sclerosis	Improves	-5.56
Multiple system atrophy (MSA)	Improves	-4.07
neuropsychiatric disorders (PANDAS, PANS)	Improves	-3.45
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-5.09
NonCeliac Gluten Sensitivity	Improves	-2.88
Obesity	Worsen	5.7
Osteoarthritis	Worsen	2.42
Osteoporosis	Improves	-2.14
Parkinson's Disease	Improves	-5.17
Psoriasis	Improves	-3.97
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-6.19
Rosacea	Improves	-2.78
Schizophrenia	Worsen	3.97
Sjögren syndrome	Improves	-5.26
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-4.89
Stress / posttraumatic stress disorder	Improves	-4.47
Systemic Lupus Erythematosus	Improves	-3.89
Type 1 Diabetes	Improves	-4.72
Type 2 Diabetes	Worsen	5.95
Ulcerative colitis	Improves	-2.95

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.