We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Ankylosing spondylitis | Worsen | 2.93 |
| Atherosclerosis | Improves | -2.22 |
| Carcinoma | Improves | -2.41 |
| Chronic Fatigue Syndrome | Improves | -2.43 |
| Chronic Kidney Disease | Improves | -3.02 |
| Chronic urticaria (Hives) | Improves | -2.41 |
| Colorectal Cancer | Worsen | 2.37 |
| Crohn's Disease | Improves | -3.92 |
| cystic fibrosis | Improves | -2.43 |
| Depression | Worsen | 3.42 |
| Generalized anxiety disorder | Improves | -3.69 |
| Histamine Issues | Improves | -2.43 |
| Inflammatory Bowel Disease | Improves | -3.93 |
| Liver Cirrhosis | Improves | -3.54 |
| ME/CFS without IBS | Improves | -2.43 |
| Multiple Sclerosis | Improves | -3.08 |
| Obesity | Improves | -3.02 |
| Osteoporosis | Improves | -3.02 |
| Rheumatoid arthritis | Improves | -0.76 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -2.43 |
| Rosacea | Worsen | 2.52 |
| Sjögren syndrome | Improves | -3.02 |
| Stress / posttraumatic stress disorder | Improves | -2.35 |
| Type 2 Diabetes | Improves | -3.69 |
| Ulcerative colitis | Worsen | 2.52 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.