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Vitamin B-12 (Cyanocobalamin) ** full range

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Sources

FOOD List Containing this flavonoid

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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

SymptomImpactPredictor of Bacteria Shift
Age: 20-30Improves-6.64
Age: 30-40Improves-4.29
Age: 40-50Improves-3.55
Age: 50-60Improves-5.37
Age: 60-70Worsen6.19
Asymptomatic: Live in house with person with probable microbiome dysfunctionImproves-2.87
Asymptomatic: Minor Health Issues (a few symptoms only)Improves-6.36
Asymptomatic: No Health IssuesWorsen6.18
Autism: Official DiagnosisImproves-8.77
Autonomic Manifestations: cardiac arrhythmiasWorsen8.72
Autonomic Manifestations: Cortisol disorders or irregularity Improves-3.48
Autonomic Manifestations: irritable bowel syndromeWorsen5.51
Autonomic Manifestations: light-headednessImproves-2.56
Autonomic Manifestations: Orthostatic intoleranceWorsen7.67
Autonomic Manifestations: palpitationsWorsen7.92
Autonomic Manifestations: urinary frequency dysfunctionWorsen8.38
Autonomic: Dizziness or faintingImproves-6.83
Autonomic: Heart rate increase after standingWorsen6.58
Autonomic: Inability to tolerate an upright positionImproves-8.86
Autonomic: Irregular heartbeatsImproves-7.52
Autonomic: Ocassional Tachycardia (Rapid heart beat)Worsen6.87
Autonomic: Shortness of breathWorsen5.79
Blood Type: A PositiveWorsen6.58
Blood Type: O PositiveImproves-8.94
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grindingImproves-5.45
Comorbid-Mouth: Dry MouthWorsen7.68
Comorbid-Mouth: Mouth SoresImproves-6.43
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndromeImproves-8.05
Comorbid: Constipation and Explosions (not diarrohea)Improves-8.82
Comorbid: FibromyalgiaWorsen6.82
Comorbid: High AnxietyImproves-9.07
Comorbid: Histamine or Mast Cell issuesImproves-8.17
Comorbid: HypothyroidismImproves-7.33
Comorbid: Inflammatory bowel disease Improves-8.7
Comorbid: MigraineImproves-8.37
Comorbid: Mold Sensitivity / ExposureWorsen6.87
Comorbid: Multiple Chemical SensitivityWorsen6.25
Comorbid: Restless LegImproves-6.91
Comorbid: Snoring (NOT Sleep ApneaImproves-8.93
DePaul University Fatigue Questionnaire : FatigueImproves-9.34
DePaul University Fatigue Questionnaire : Impaired Memory & concentrationImproves-9.54
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired Improves-9.15
Gender: FemaleImproves-6.78
Gender: MaleImproves-3.74
General: DepressionImproves-7.16
General: FatigueWorsen7.64
General: HeadachesWorsen6.06
General: Myalgia (pain)Worsen6.43
General: Sinus issues with headachesImproves-8.32
Immune Manifestations: Abdominal PainImproves-7.4
Immune Manifestations: Alcohol IntolerantImproves-7
Immune Manifestations: BloatingWorsen5.61
Immune Manifestations: ConstipationWorsen7.11
Immune Manifestations: DiarrheaWorsen7.01
Immune Manifestations: general malaiseWorsen6.06
Immune Manifestations: Hair lossImproves-3.47
Immune Manifestations: Inflammation (General)Improves-9.01
Immune Manifestations: Inflammation of skin, eyes or jointsWorsen4.01
Immune Manifestations: medication sensitivities.Improves-5.06
Immune Manifestations: Mucus in the stoolImproves-8.81
Immune Manifestations: new food sensitivitiesWorsen7.58
Immune Manifestations: tender lymph nodesWorsen7.81
Immune: Chronic SinusitisWorsen5.21
Immune: Recurrent Sore throatWorsen5.22
Immune: Sensitivity to smell/food/medication/chemicalsWorsen5.24
Immune: Tender / sore lymph nodesWorsen6.25
Infection: Epstein-Barr virusImproves-7.59
Infection: Human Herpesvirus 6 (HHV6)Improves-6.45
Infection: MycoplasmaImproves-8.12
Infection: Parasite - OtherImproves-4.17
Joint: RednessImproves-4.4
Joint: Stiffness and swellingImproves-6.52
Joint: Sudden and severe episodes of painWorsen6.28
Joint: TendernessImproves-6.85
Neurocognitive: Absent-mindedness or forgetfulnessImproves-3.7
Neurocognitive: Brain FogWorsen5.5
Neurocognitive: Can only focus on one thing at a timeImproves-6.43
Neurocognitive: Difficulty expressing thoughtsWorsen5.46
Neurocognitive: Difficulty paying attention for a long period of timeImproves-6.39
Neurocognitive: Difficulty understanding thingsWorsen3.35
Neurocognitive: Problems remembering thingsImproves-6.74
Neurocognitive: Slowness of thoughtImproves-6.53
Neurocognitive: Unable to focus vision and/or attentionImproves-7.47
Neuroendocrine Manifestations: abnormal appetiteImproves-2.87
Neuroendocrine Manifestations: Air HungerWorsen6.87
Neuroendocrine Manifestations: cold extremitiesWorsen7.59
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)Improves-2.86
Neuroendocrine Manifestations: Excessive adrenalineImproves-7.52
Neuroendocrine Manifestations: intolerance of extremes of heat and coldWorsen7.52
Neuroendocrine Manifestations: marked weight change Improves-3.48
Neuroendocrine Manifestations: Muscle weakness Worsen7.9
Neuroendocrine Manifestations: NeuralgiaImproves-3.52
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)Improves-8.54
Neuroendocrine Manifestations: Rapid muscular fatiguabilityWorsen6.73
Neuroendocrine Manifestations: recurrent feelings of feverishnessImproves-3.88
Neuroendocrine Manifestations: subnormal body temperatureWorsen6.25
Neuroendocrine Manifestations: sweating episodesWorsen6.44
Neuroendocrine Manifestations: worsening of symptoms with stress.Worsen7.3
Neuroendocrine: Alcohol intoleranceWorsen6.06
Neuroendocrine: Chills or shiversWorsen6.76
Neuroendocrine: Cold limbs (e.g. arms, legs hands)Improves-4.23
Neuroendocrine: Feeling hot or cold for no reasonWorsen7.95
Neuroendocrine: Feeling like you have a high temperatureWorsen6.94
Neuroendocrine: Feeling like you have a low temperatureWorsen7.5
Neuroendocrine: Lack of appetiteWorsen6.84
Neuroendocrine: Lost or gained weight without tryingWorsen7.54
Neuroendocrine: Sweating handsWorsen2.75
Neurological-Audio: hypersensitivity to noiseWorsen7.28
Neurological-Audio: Tinnitus (ringing in ear)Improves-6.27
Neurological-Sleep: Chaotic diurnal sleep rhythms (Irratic Sleep)Worsen6.92
Neurological-Sleep: InsomniaImproves-7.21
Neurological-Sleep: Night SweatsWorsen3.25
Neurological-Sleep: Sleep ApneaWorsen5.73
Neurological-Sleep: Vivid Dreams/NightmaresWorsen7.6
Neurological-Vision: Blurred VisionWorsen7.56
Neurological-Vision: inability to focus eye/visionImproves-7.86
Neurological-Vision: photophobia (Light Sensitibity)Improves-7.6
Neurological: Cognitive OverloadWorsen8.16
Neurological: Difficulty processing information (Understanding)Worsen7.46
Neurological: Difficulty readingImproves-6.99
Neurological: DysautonomiaImproves-3.83
Neurological: emotional overloadWorsen7.75
Neurological: Executive Decision Making (Difficulty making)Improves-7.37
Neurological: fasciculations Worsen7.89
Neurological: High degree of Empathy before onsetWorsen7.49
Neurological: Impairment of concentrationWorsen8
Neurological: Joint hypermobilityImproves-8
Neurological: Seasonal Affective Disorder (SAD)Improves-6.8
Neurological: Short-term memory issuesWorsen7.76
Neurological: Spatial instability and disorientationWorsen7.5
Neurological: Word-finding problemsWorsen5.16
Official Diagnosis: Allergic Rhinitis (Hay Fever)Improves-8.76
Official Diagnosis: Autoimmune DiseaseImproves-7.89
Official Diagnosis: Chronic Fatigue SyndromeWorsen6.75
Official Diagnosis: Irritable Bowel SyndromeImproves-8.34
Official Diagnosis: Mast Cell DysfunctionImproves-8.51
Onset: 2000-2010Worsen5.03
Onset: 2010-2020Worsen7.2
Onset: GradualWorsen6.8
Onset: less than 16 years since onsetWorsen3.47
Other: Sensitivity to moldWorsen6.85
Pain: Chest painImproves-7.16
Pain: Eye painImproves-6.54
Pain: Joint painWorsen7.06
Pain: Myofascial painImproves-4.87
Pain: Pain or aching in musclesWorsen7.86
Pain: Sensitivity to painImproves-8.28
Post-exertional malaise: Difficulty reading after mild physical or mental activityWorsen4.31
Post-exertional malaise: GeneralWorsen7.48
Post-exertional malaise: Inappropriate loss of physical and mental stamina,Worsen4.23
Post-exertional malaise: Mentally tired after the slightest effortWorsen5.01
Post-exertional malaise: Next-day soreness after everyday activitiesWorsen3.42
Post-exertional malaise: Physically drained or sick after mild activityWorsen6.72
Post-exertional malaise: Rapid cognitive fatigability, Worsen8.16
Post-exertional malaise: Worsening of symptoms after mild mental activityWorsen7.47
Post-exertional malaise: Worsening of symptoms after mild physical activityWorsen6.6
Sleep: Daytime drowsinessWorsen6.75
Sleep: Need to nap dailyImproves-6.36
Sleep: Problems falling asleepWorsen8.14
Sleep: Problems staying asleepWorsen5.96
Sleep: Unrefreshed sleepWorsen8.06
Sleep: Waking up early in the morning (e.g. 3 AM)Improves-7.23

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

SymptomImpactPredictor of Bacteria Shift
AcneWorsen5.97
ADHDImproves-8.22
Allergic Rhinitis (Hay Fever)Improves-3.24
AllergiesWorsen7.73
Alzheimer's diseaseWorsen8.83
Amyotrophic lateral sclerosis (ALS) Motor NeuronWorsen7.76
Ankylosing spondylitisWorsen9.22
AsthmaWorsen5.67
AtherosclerosisImproves-9.6
AutismWorsen9.73
Autoimmune DiseaseImproves-3.29
Barrett esophagus cancerImproves-6.03
Brain TraumaImproves-6.89
CarcinomaImproves-9.03
Celiac DiseaseImproves-5.4
Chronic Fatigue SyndromeImproves-7.4
Chronic Kidney DiseaseImproves-7.56
Chronic urticaria (Hives)Improves-8.55
Colorectal CancerImproves-10.61
Crohn's DiseaseImproves-9.75
cystic fibrosisImproves-7.49
DepressionImproves-9.13
EpilepsyWorsen8.25
FibromyalgiaWorsen7.49
Functional constipation / chronic idiopathic constipationImproves-8.21
Gastro-esophageal reflux disease (Gerd) including Barrett's esophagusWorsen7.3
Generalized anxiety disorderImproves-8.69
GoutImproves-6.12
Graves' diseaseWorsen6.97
Hashimoto's thyroiditisImproves-7.8
High Blood PressureWorsen8.63
Histamine IssuesImproves-8.9
Histamine Issues From UbiomeWorsen6.01
hypercholesterolemia (High Cholesterol)Improves-7.01
IgA nephropathy (IgAN)Worsen8.52
Inflammatory Bowel DiseaseImproves-9.07
Irritable Bowel SyndromeImproves-9.4
Juvenile idiopathic arthritisWorsen5.45
Liver CirrhosisImproves-9.14
ME/CFS with IBSImproves-8.5
ME/CFS without IBSImproves-9.27
Metabolic SyndromeWorsen7.16
Mood DisordersImproves-7.57
Multiple SclerosisImproves-8.86
neuropsychiatric disorders (PANDAS, PANS)Improves-8.02
Non-alcoholic Fatty Liver Disease (nafld) NonalcoholicImproves-6.8
Non-Celiac Gluten SensitivityWorsen1.35
ObesityImproves-9.07
Parkinson's DiseaseImproves-8.14
PsoriasisImproves-9.34
Rheumatoid arthritisWorsen8.15
rheumatoid arthritis (RA) and Spondyloarthritis (SpA)Improves-8.43
SchizophreniaWorsen7.86
SclerosisWorsen6.54
Sjögren syndromeImproves-8.4
Small Intestinal Bacterial Overgrowth (SIBO)Improves-9.08
Stress / post-traumatic stress disorderImproves-9.85
Systemic Lupus ErythematosusImproves-8.95
Type 1 DiabetesImproves-7.25
Type 2 DiabetesImproves-8.21
Ulcerative colitisWorsen8.38

Bacteria Impacted

Suggest a missed study:

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

📓 - direct citation | 👪 - Impacts Parent Taxa | 👶 - Impacts Child Taxa | 🧙 - Inferred
Taxonomy Rank Effect Citations
Levinea Young et al. 1971 genus Decreases 📓 Source Study
Escherichia genus Decreases 📓 Source Study
Pseudomonas genus Decreases 📓 Source Study
Shigella genus Decreases 📓 Source Study
Pseudomonas chlororaphis group genus Decreases 👪 Source Study
Bacteroidaeota phylum Increases 📓 Source Study
Firmicutes phylum Increases 📓 Source Study
ATCC 51112 species Decreases 👪 Source Study
Citrobacter amalonaticus species Decreases 👪 Source Study
Citrobacter sp. species Decreases 👪 Source Study
Citrobacter sp. BW4 species Decreases 👪 Source Study
Citrobacter sp. HD4.9 species Decreases 👪 Source Study
JCM 1658 species Decreases 👪 Source Study
Achromobacter georgiopolitanum species Decreases 👪 Source Study
AJ 2129 species Decreases 👪 Source Study
Arthrobacter sp. BDR2P1B1-M species Decreases 👪 Source Study
ATCC 35469 species Decreases 👪 Source Study
ATCC 8700 species Decreases 👪 Source Study
ATCC BAA-257 species Decreases 👪 Source Study
Bacterium sonnei Levine 1920 species Decreases 👪 Source Study
CCM 7280 species Decreases 👪 Source Study
CCM 7990 species Decreases 👪 Source Study
CCTCC AB 2012022 species Decreases 👪 Source Study
CCTCC AB 207151 species Decreases 👪 Source Study
CCUG 51504 species Decreases 👪 Source Study
CCUG 51516 species Decreases 👪 Source Study
CCUG 53116 species Decreases 👪 Source Study
CCUG 58201 species Decreases 👪 Source Study
CCUG 63249 species Decreases 👪 Source Study
CECT 7670 species Decreases 👪 Source Study
CECT 7985 species Decreases 👪 Source Study
CECT 8338 species Decreases 👪 Source Study
CFBP 11706 species Decreases 👪 Source Study
CIP 109839 species Decreases 👪 Source Study
CSUR P1224 species Decreases 👪 Source Study
DSM 101070 species Decreases 👪 Source Study
DSM 16611 species Decreases 👪 Source Study
DSM 17875 species Decreases 👪 Source Study
DSM 28040 species Decreases 👪 Source Study
DSM 28043 species Decreases 👪 Source Study
DSM 4782 species Decreases 👪 Source Study
DSM 6978 species Decreases 👪 Source Study
Escherichia albertii species Decreases 👪 Source Study
Escherichia coli Biovare species Decreases 👪 Source Study
Escherichia marmotae species Decreases 👪 Source Study
Escherichia sp. species Decreases 👪 Source Study
Escherichia sp. 1_1_43 species Decreases 👪 Source Study
Escherichia sp. 4_1_40B species Decreases 👪 Source Study
fluorescent pseudomonads species Decreases 👪 Source Study
JCM 14963 species Decreases 👪 Source Study
KCTC 32246 species Decreases 👪 Source Study
KCTC 32541 species Decreases 👪 Source Study
Pseudomonas denitrificans ATCC 13867 species Decreases 👪 Source Study
Pseudomonas gingeri species Decreases 👪 Source Study
Pseudomonas oryzae species Decreases 👪 Source Study
Pseudomonas putida group species Decreases 👪 Source Study
Pseudomonas saponiphila species Decreases 👪 Source Study
Pseudomonas sp. 02C 26 species Decreases 👪 Source Study
Pseudomonas sp. 31-12 species Decreases 👪 Source Study
Pseudomonas sp. 7SR1 species Decreases 👪 Source Study
Pseudomonas sp. a101-18-2 species Decreases 👪 Source Study
Pseudomonas sp. a111-5 species Decreases 👪 Source Study
Pseudomonas sp. ACM7 species Decreases 👪 Source Study
Pseudomonas sp. CC6-YY-74 species Decreases 👪 Source Study
Pseudomonas sp. CMR12a species Decreases 👪 Source Study
Pseudomonas sp. CMR5c species Decreases 👪 Source Study
Pseudomonas sp. DQ-01 species Decreases 👪 Source Study
Pseudomonas sp. DTU12.3 species Decreases 👪 Source Study
Pseudomonas sp. DY-1 species Decreases 👪 Source Study
Pseudomonas sp. G1116 species Decreases 👪 Source Study
Pseudomonas sp. GmFRB023 species Decreases 👪 Source Study
Pseudomonas sp. KB23 species Decreases 👪 Source Study
Pseudomonas sp. KVS86 species Decreases 👪 Source Study
Pseudomonas sp. LH1G9 species Decreases 👪 Source Study
Pseudomonas sp. LPH1 species Decreases 👪 Source Study
Pseudomonas sp. LTJR-52 species Decreases 👪 Source Study
Pseudomonas sp. MFY143 species Decreases 👪 Source Study
Pseudomonas sp. MRSN12121 species Decreases 👪 Source Study
Pseudomonas sp. MT-1 species Decreases 👪 Source Study
Pseudomonas sp. NS1(2017) species Decreases 👪 Source Study
Pseudomonas sp. PcFRB072 species Decreases 👪 Source Study
Pseudomonas sp. PcFRB119 species Decreases 👪 Source Study
Pseudomonas sp. PONIH3 species Decreases 👪 Source Study
Pseudomonas sp. ps4-2 species Decreases 👪 Source Study
Pseudomonas sp. QZS01 species Decreases 👪 Source Study
Pseudomonas sp. R4-34-07 species Decreases 👪 Source Study
Pseudomonas sp. R5-89-07 species Decreases 👪 Source Study
Pseudomonas sp. RU47 species Decreases 👪 Source Study
Pseudomonas sp. S-6-2 species Decreases 👪 Source Study
Pseudomonas sp. StFLB209 species Decreases 👪 Source Study
Pseudomonas sp. SWI36 species Decreases 👪 Source Study
Pseudomonas sp. TCU-HL1 species Decreases 👪 Source Study
Pseudomonas sp. TMW 2.1634 species Decreases 👪 Source Study
Pseudomonas sp. URMO17WK12:I11 species Decreases 👪 Source Study
Pseudomonas sp. WCS374 species Decreases 👪 Source Study
Pseudomonas stutzeri group species Decreases 👪 Source Study
Pseudomonas syringae group species Decreases 👪 Source Study
Shigella dysenteriae species Decreases 👪 Source Study

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