We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 0-10 | Worsen | 1.25 |
Age: 20-30 | Worsen | 1.2 |
Age: 60-70 | Worsen | 3.34 |
Autism: Official Diagnosis | Worsen | 3.75 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 2.84 |
Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -1.7 |
Autonomic Manifestations: irritable bowel syndrome | Worsen | 2.39 |
Autonomic Manifestations: Orthostatic intolerance | Improves | -3.04 |
Autonomic Manifestations: palpitations | Improves | -2.93 |
Autonomic: Shortness of breath | Improves | -2.86 |
Blood Type: A Positive | Worsen | 1.76 |
Blood Type: O Positive | Worsen | 3.96 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 3.34 |
Comorbid-Mouth: Dry Mouth | Improves | -2.99 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.98 |
Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 4.29 |
Comorbid: Fibromyalgia | Improves | -2.96 |
Comorbid: High Anxiety | Worsen | 3.96 |
Comorbid: Histamine or Mast Cell issues | Worsen | 3.5 |
Comorbid: Hypothyroidism | Worsen | 2.91 |
Comorbid: Inflammatory bowel disease | Worsen | 3.12 |
Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
Comorbid: Migraine | Worsen | 2.9 |
Comorbid: Multiple Chemical Sensitivity | Improves | -2.9 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 3.78 |
Condition: ME/CFS with IBS | Improves | -2.8 |
DePaul University Fatigue Questionnaire : Allergies | Improves | -2.52 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 2.12 |
DePaul University Fatigue Questionnaire : Depression | Improves | -2.41 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 2.93 |
DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.4 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 1.2 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.71 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.16 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 1.2 |
General: Fatigue | Improves | -2.9 |
General: Headaches | Worsen | 2.39 |
Immune Manifestations: Alcohol Intolerant | Worsen | 2.39 |
Immune Manifestations: Bloating | Worsen | 2.39 |
Immune Manifestations: Constipation | Worsen | 2.39 |
Immune Manifestations: Diarrhea | Improves | -2.71 |
Immune Manifestations: general malaise | Worsen | 2.39 |
Immune Manifestations: new food sensitivities | Improves | -2.71 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 2.61 |
Infection: Mycoplasma | Worsen | 2.91 |
Infection: Parasite - Other | Worsen | 3.93 |
Joint: Stiffness and swelling | Worsen | 3.78 |
Joint: Tenderness | Worsen | 3.01 |
Neurocognitive: Absent-mindedness or forgetfulness | Worsen | 2.39 |
Neurocognitive: Brain Fog | Worsen | 2.39 |
Neurocognitive: Can only focus on one thing at a time | Worsen | 2.39 |
Neurocognitive: Slowness of thought | Worsen | 2.39 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.63 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.66 |
Neuroendocrine Manifestations: Muscle weakness | Improves | -3.57 |
Neuroendocrine Manifestations: subnormal body temperature | Worsen | 2.39 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 2.39 |
Neuroendocrine: Alcohol intolerance | Worsen | 3.34 |
Neuroendocrine: Chills or shivers | Improves | -2.71 |
Neuroendocrine: Feeling hot or cold for no reason | Improves | -2.71 |
Neuroendocrine: Feeling like you have a high temperature | Improves | -2.71 |
Neuroendocrine: Feeling like you have a low temperature | Improves | -2.07 |
Neuroendocrine: Lack of appetite | Worsen | 1.32 |
Neuroendocrine: Lost or gained weight without trying | Improves | -3.15 |
Neurological-Audio: hypersensitivity to noise | Worsen | 2.39 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 1.9 |
Neurological-Vision: Blurred Vision | Improves | -2.93 |
Neurological-Vision: inability to focus eye/vision | Worsen | 3.34 |
Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 2.91 |
Neurological: Difficulty reading | Worsen | 3.34 |
Neurological: emotional overload | Worsen | 3.42 |
Neurological: fasciculations | Worsen | 3.18 |
Neurological: High degree of Empathy before onset | Worsen | 2.74 |
Neurological: Impairment of concentration | Worsen | 2.39 |
Neurological: Short-term memory issues | Worsen | 2.47 |
Neurological: Slowed speech | Improves | -2.76 |
Neurological: Spatial instability and disorientation | Worsen | 2.74 |
Neurological: Word-finding problems | Improves | -1.79 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 4.07 |
Official Diagnosis: Irritable Bowel Syndrome | Worsen | 2.39 |
Official Diagnosis: Mast Cell Dysfunction | Worsen | 4.15 |
Onset: 2010-2020 | Worsen | 2.39 |
Onset: Gradual | Worsen | 4.35 |
Onset: less than 02 years since onset | Worsen | 2.74 |
Other: Sensitivity to mold | Improves | -1.76 |
Pain: Pain or aching in muscles | Improves | -2.71 |
Pain: Sensitivity to pain | Worsen | 2.63 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.01 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 2.88 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 3.42 |
Sleep: Daytime drowsiness | Worsen | 2.39 |
Sleep: Problems staying asleep | Worsen | 2.39 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.39 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Improves | -3.94 |
ADHD | Worsen | 1.16 |
Allergic Rhinitis (Hay Fever) | Improves | -1.12 |
Allergies | Worsen | 3.79 |
Alzheimer's disease | Worsen | 4.1 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 4.01 |
Ankylosing spondylitis | Improves | -3.57 |
Asthma | Improves | -1.65 |
Atherosclerosis | Improves | -3.44 |
Autism | Improves | -2.09 |
Barrett esophagus cancer | Worsen | 4.08 |
Bipolar Disorder | Improves | -2.62 |
Brain Trauma | Improves | -3.92 |
Carcinoma | Improves | -4.36 |
Celiac Disease | Improves | -4.67 |
Cerebral Palsy | Improves | -2.74 |
Chronic Fatigue Syndrome | Improves | -3.06 |
Chronic Kidney Disease | Worsen | 2.32 |
Chronic Lyme | Improves | -3.55 |
Chronic Urticaria (Hives) | Improves | -4.32 |
Colorectal Cancer | Improves | -4.93 |
Coronary artery disease | Improves | -4.16 |
COVID-19 | Improves | -4.37 |
Crohn's Disease | Worsen | 2.63 |
cystic fibrosis | Improves | -3.57 |
Depression | Improves | -4.97 |
Epilepsy | Improves | -4.39 |
Fibromyalgia | Improves | -3.5 |
Functional constipation / chronic idiopathic constipation | Improves | -4.48 |
gallstone disease (gsd) | Improves | -3.86 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 0.45 |
Gout | Improves | -2.91 |
Graves' disease | Worsen | 3.92 |
Hashimoto's thyroiditis | Worsen | 2.32 |
High Blood Pressure | Worsen | 2.82 |
Histamine Issues | Improves | -2.39 |
Histamine Issues From Ubiome | Worsen | 3.03 |
hypercholesterolemia (High Cholesterol) | Worsen | 3.38 |
Hyperlipidemia (High Blood Fats) | Worsen | 4.32 |
IgA nephropathy (IgAN) | Improves | -3.18 |
Inflammatory Bowel Disease | Improves | -4.74 |
Insomnia | Improves | -3.56 |
Irritable Bowel Syndrome | Improves | -3.87 |
Liver Cirrhosis | Improves | -5.76 |
ME/CFS with IBS | Improves | -4.43 |
ME/CFS without IBS | Improves | -4.21 |
Metabolic Syndrome | Improves | -2.9 |
Mood Disorders | Improves | -3.53 |
Multiple Sclerosis | Improves | -4.08 |
Multiple system atrophy (MSA) | Worsen | 2.28 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -0.75 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -5.42 |
NonCeliac Gluten Sensitivity | Improves | -3.21 |
Obesity | Improves | -4.82 |
Osteoarthritis | Improves | -2.83 |
Osteoporosis | Worsen | 4.09 |
Parkinson's Disease | Worsen | 3.05 |
Psoriasis | Improves | -3.38 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -5.32 |
Rosacea | Worsen | 3.31 |
Schizophrenia | Worsen | 4.43 |
Sjögren syndrome | Improves | -3.92 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.05 |
Stress / posttraumatic stress disorder | Improves | -5.25 |
Systemic Lupus Erythematosus | Improves | -4.41 |
Type 1 Diabetes | Worsen | 4.44 |
Type 2 Diabetes | Improves | -4.91 |
Ulcerative colitis | Improves | -5.44 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.