We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.48 |
| Age: 60-70 | Improves | -3.8 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.95 |
| Asymptomatic: No Health Issues | Worsen | 1.01 |
| Autism: Official Diagnosis | Worsen | 3.13 |
| Autonomic Manifestations: cardiac arrhythmias | Improves | -2.96 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 3.05 |
| Autonomic Manifestations: irritable bowel syndrome | Improves | -0.49 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -0.38 |
| Autonomic Manifestations: palpitations | Improves | -2.92 |
| Autonomic: Heart rate increase after standing | Worsen | 3.05 |
| Autonomic: Inability to tolerate an upright position | Worsen | 2.62 |
| Autonomic: Irregular heartbeats | Worsen | 1.15 |
| Autonomic: Shortness of breath | Worsen | 2.26 |
| Blood Type: A Positive | Improves | -1.82 |
| Blood Type: O Positive | Improves | -3.74 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -3.37 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.81 |
| Comorbid-Mouth: Mouth Sores | Improves | -1.84 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -3.15 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -2.02 |
| Comorbid: Fibromyalgia | Improves | -3.15 |
| Comorbid: High Anxiety | Worsen | 2.54 |
| Comorbid: Histamine or Mast Cell issues | Improves | -3.72 |
| Comorbid: Hypothyroidism | Improves | -3.2 |
| Comorbid: Inflammatory bowel disease | Worsen | 2.31 |
| Comorbid: Migraine | Improves | -2.95 |
| Comorbid: Mold Sensitivity / Exposure | Worsen | 3.05 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -2.02 |
| DePaul University Fatigue Questionnaire : Allergies | Improves | -2.73 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Improves | -3.19 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Improves | -2.68 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -2.02 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Improves | -2.99 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.52 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -0.07 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 1.41 |
| General: Depression | Improves | -1.71 |
| General: Fatigue | Improves | -3.38 |
| General: Headaches | Improves | -1.88 |
| General: Myalgia (pain) | Worsen | 2.49 |
| General: Sinus issues with headaches | Improves | -1.88 |
| Immune Manifestations: Abdominal Pain | Improves | -1.48 |
| Immune Manifestations: Alcohol Intolerant | Improves | -3.2 |
| Immune Manifestations: Bloating | Improves | -3.69 |
| Immune Manifestations: Constipation | Improves | -3.1 |
| Immune Manifestations: Diarrhea | Improves | -2.55 |
| Immune Manifestations: general malaise | Improves | -3.1 |
| Immune Manifestations: Hair loss | Worsen | 1.9 |
| Immune Manifestations: Inflammation (General) | Improves | -3.9 |
| Immune Manifestations: medication sensitivities. | Worsen | 3.05 |
| Immune Manifestations: Mucus in the stool | Worsen | 3.05 |
| Immune Manifestations: tender lymph nodes | Worsen | 0 |
| Immune: Tender / sore lymph nodes | Worsen | 1.89 |
| Infection: Epstein-Barr virus | Worsen | 3.34 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 2.03 |
| Infection: Mycoplasma | Worsen | 3.05 |
| Infection: Parasite - Other | Worsen | 3.05 |
| Joint: Redness | Improves | -3.41 |
| Joint: Stiffness and swelling | Improves | -3.37 |
| Joint: Tenderness | Worsen | 1.15 |
| Neurocognitive: Brain Fog | Improves | -2.95 |
| Neurocognitive: Can only focus on one thing at a time | Worsen | 0.64 |
| Neurocognitive: Difficulty paying attention for a long period of time | Improves | -2.95 |
| Neurocognitive: Problems remembering things | Improves | -2.95 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -2.5 |
| Neuroendocrine Manifestations: Air Hunger | Improves | -2.91 |
| Neuroendocrine Manifestations: cold extremities | Improves | -2.65 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -2.89 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 3.05 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 1.15 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 2.71 |
| Neuroendocrine Manifestations: sweating episodes | Improves | -1.71 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Improves | -2.82 |
| Neuroendocrine: Alcohol intolerance | Improves | -1.26 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -1.71 |
| Neuroendocrine: Feeling hot or cold for no reason | Improves | -2.72 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 0 |
| Neuroendocrine: Lack of appetite | Improves | -2.88 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -1.64 |
| Neurological-Audio: hypersensitivity to noise | Improves | -2.87 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -3.16 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.38 |
| Neurological-Sleep: Insomnia | Improves | -2.95 |
| Neurological-Sleep: Night Sweats | Improves | -1.71 |
| Neurological-Sleep: Sleep Apnea | Improves | -1.97 |
| Neurological-Vision: Blurred Vision | Improves | -2.92 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.5 |
| Neurological-Vision: photophobia (Light Sensitivity) | Improves | -3.2 |
| Neurological: Cognitive/Sensory Overload | Improves | -2.89 |
| Neurological: Difficulty processing information (Understanding) | Worsen | 3.05 |
| Neurological: Difficulty reading | Improves | -2.5 |
| Neurological: emotional overload | Worsen | 3.05 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 1.9 |
| Neurological: fasciculations | Worsen | 0.64 |
| Neurological: High degree of Empathy before onset | Worsen | 0 |
| Neurological: Impairment of concentration | Improves | -2.24 |
| Neurological: Joint hypermobility | Worsen | 1.15 |
| Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.49 |
| Neurological: Short-term memory issues | Worsen | 3.05 |
| Neurological: Spatial instability and disorientation | Worsen | 0 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -2.56 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.96 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.95 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -2.55 |
| Onset: 2010-2020 | Improves | -3.05 |
| Other: Sensitivity to mold | Improves | -1.64 |
| Other: Sensitivity to vibrations | Worsen | 2.74 |
| Pain: Chest pain | Worsen | 2.96 |
| Pain: Eye pain | Improves | -2.92 |
| Pain: Sensitivity to pain | Worsen | 3.48 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Improves | -1.71 |
| Post-exertional malaise: General | Worsen | 0 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 1.89 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 0 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 0 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 1.41 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 0 |
| Sleep: Daytime drowsiness | Improves | -3.58 |
| Sleep: Problems staying asleep | Improves | -1.71 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -2.95 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 1.38 |
| ADHD | Worsen | 4.35 |
| Allergies | Improves | -3.64 |
| Alzheimer's disease | Worsen | 2.98 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 0 |
| Ankylosing spondylitis | Worsen | 4.27 |
| Asthma | Worsen | 1.89 |
| Atherosclerosis | Worsen | 4.22 |
| Autism | Improves | -5.24 |
| Barrett esophagus cancer | Worsen | 2.1 |
| Brain Trauma | Worsen | 3.94 |
| Carcinoma | Worsen | 2.23 |
| Celiac Disease | Improves | -3.87 |
| Chronic Fatigue Syndrome | Improves | -4.8 |
| Chronic Kidney Disease | Worsen | 3.19 |
| Chronic urticaria (Hives) | Improves | -3.32 |
| Colorectal Cancer | Worsen | 3.41 |
| Coronary artery disease | Improves | -3.06 |
| Crohn's Disease | Improves | -4.83 |
| Depression | Worsen | 4.1 |
| Epilepsy | Improves | -3.65 |
| Fibromyalgia | Worsen | 3.27 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.9 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.06 |
| Generalized anxiety disorder | Improves | -3.47 |
| Gout | Improves | -3.09 |
| Graves' disease | Improves | -2.88 |
| Hashimoto's thyroiditis | Worsen | 3.61 |
| High Blood Pressure | Improves | -2.62 |
| Histamine Issues | Worsen | 2.78 |
| Histamine Issues From Ubiome | Worsen | 1.75 |
| Hyperlipidemia (High Blood Fats) | Improves | -1.31 |
| hypertension (High Blood Pressure | Worsen | 2.92 |
| IgA nephropathy (IgAN) | Worsen | 3.36 |
| Inflammatory Bowel Disease | Improves | -4.77 |
| Insomnia | Worsen | 3.05 |
| Irritable Bowel Syndrome | Improves | -1.85 |
| Liver Cirrhosis | Worsen | 3.62 |
| ME/CFS with IBS | Improves | -3.65 |
| ME/CFS without IBS | Improves | -4.22 |
| Mood Disorders | Worsen | 0 |
| Multiple Sclerosis | Worsen | 2.59 |
| Multiple system atrophy (MSA) | Improves | -3.99 |
| neuropsychiatric disorders (PANDAS, PANS) | Worsen | 2.1 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.32 |
| Obesity | Worsen | 2.46 |
| Osteoporosis | Worsen | 2.1 |
| Parkinson's Disease | Improves | -3.29 |
| Psoriasis | Improves | -3.87 |
| Rheumatoid arthritis | Worsen | 4.32 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.77 |
| Rosacea | Worsen | 2.31 |
| Schizophrenia | Worsen | 2.54 |
| Sclerosis | Worsen | 2.81 |
| Sjögren syndrome | Improves | -2.1 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.79 |
| Stress / posttraumatic stress disorder | Improves | -4.9 |
| Systemic Lupus Erythematosus | Improves | -3.18 |
| Type 1 Diabetes | Worsen | 1.36 |
| Type 2 Diabetes | Worsen | 4.48 |
| Ulcerative colitis | Improves | -4.26 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.