We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Comorbid-Mouth: Dry Mouth | Worsen | 2.74 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.8 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Short-term memory issues | Worsen | 2.74 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.48 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.74 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -3.47 |
| ADHD | Worsen | 3.56 |
| Allergies | Improves | -2.39 |
| Alzheimer's disease | Improves | -3.56 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.74 |
| Ankylosing spondylitis | Worsen | 3.25 |
| Asthma | Worsen | 3.48 |
| Atherosclerosis | Worsen | 2.89 |
| Autism | Improves | -4.48 |
| Barrett esophagus cancer | Worsen | 1.46 |
| Brain Trauma | Worsen | 1.29 |
| Carcinoma | Worsen | 1.32 |
| Celiac Disease | Improves | -3.34 |
| Chronic Fatigue Syndrome | Improves | -4.43 |
| Chronic Kidney Disease | Improves | -3.14 |
| Chronic urticaria (Hives) | Improves | -3.06 |
| Colorectal Cancer | Improves | -4.32 |
| Crohn's Disease | Improves | -3.02 |
| cystic fibrosis | Worsen | 2.39 |
| Depression | Worsen | 3.15 |
| Epilepsy | Improves | -3.01 |
| Fibromyalgia | Improves | -3.47 |
| gallstone disease (gsd) | Improves | -0.86 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
| Generalized anxiety disorder | Improves | -2.86 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Improves | -3.51 |
| High Blood Pressure | Improves | -3.38 |
| Histamine Issues | Worsen | 1.58 |
| Histamine Issues From Ubiome | Improves | -2.72 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.63 |
| IgA nephropathy (IgAN) | Improves | -4.07 |
| Inflammatory Bowel Disease | Worsen | 1.55 |
| Irritable Bowel Syndrome | Improves | -5.09 |
| Liver Cirrhosis | Improves | -4.05 |
| ME/CFS with IBS | Improves | -2.88 |
| ME/CFS without IBS | Improves | -2.88 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 1.3 |
| Multiple system atrophy (MSA) | Improves | -1.3 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.05 |
| Obesity | Worsen | 2.14 |
| Osteoporosis | Worsen | 1.63 |
| Parkinson's Disease | Worsen | 4.58 |
| Psoriasis | Worsen | 2.96 |
| Rheumatoid arthritis | Improves | -3.83 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 4.04 |
| Rosacea | Worsen | 1.3 |
| Schizophrenia | Worsen | 4.11 |
| Sjögren syndrome | Improves | -3.33 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 1.63 |
| Stress / posttraumatic stress disorder | Worsen | 2.4 |
| Systemic Lupus Erythematosus | Improves | -2.88 |
| Type 1 Diabetes | Improves | -2.72 |
| Type 2 Diabetes | Worsen | 2.74 |
| Ulcerative colitis | Improves | -2.67 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.