We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.76 |
| Age: 30-40 | Worsen | 1.79 |
| Age: 60-70 | Improves | -3.24 |
| Autonomic Manifestations: cardiac arrhythmias | Improves | -3.94 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 1.79 |
| Blood Type: A Positive | Worsen | 1.86 |
| Blood Type: O Positive | Improves | -0.67 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.56 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.74 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -3.24 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.24 |
| Comorbid: Fibromyalgia | Improves | -2.96 |
| Comorbid: High Anxiety | Improves | -2 |
| Comorbid: Histamine or Mast Cell issues | Improves | -2.56 |
| Comorbid: Hypothyroidism | Improves | -2.56 |
| Comorbid: Inflammatory bowel disease | Worsen | 1.61 |
| Comorbid: Migraine | Worsen | 1.86 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.68 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.24 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 2.99 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 2.99 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 1.61 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.62 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 2.29 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.99 |
| General: Headaches | Improves | -2.83 |
| Immune Manifestations: Abdominal Pain | Improves | -2.56 |
| Immune Manifestations: Bloating | Improves | -2.56 |
| Immune Manifestations: Diarrhea | Worsen | 2.62 |
| Joint: Stiffness and swelling | Improves | -2.85 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -2.56 |
| Neurocognitive: Difficulty paying attention for a long period of time | Improves | -2.56 |
| Neurocognitive: Problems remembering things | Improves | -2.56 |
| Neurocognitive: Slowness of thought | Improves | -2.56 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -2.56 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -1.68 |
| Neuroendocrine Manifestations: subnormal body temperature | Improves | -2.56 |
| Neuroendocrine: Alcohol intolerance | Improves | -2.85 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neuroendocrine: Lost or gained weight without trying | Worsen | 2.62 |
| Neurological-Audio: hypersensitivity to noise | Improves | -2.56 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -2.56 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.56 |
| Neurological-Sleep: Insomnia | Improves | -2.56 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.56 |
| Neurological-Vision: photophobia (Light Sensitivity) | Improves | -2.56 |
| Neurological: Difficulty reading | Improves | -2.56 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -2.56 |
| Neurological: fasciculations | Improves | -1.66 |
| Neurological: High degree of Empathy before onset | Worsen | 3.34 |
| Neurological: Short-term memory issues | Worsen | 2.74 |
| Neurological: Slowed speech | Improves | -1.61 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Neurological: Word-finding problems | Worsen | 1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -2 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.56 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -2.85 |
| Onset: 2010-2020 | Improves | -2.56 |
| Pain: Chest pain | Worsen | 2.96 |
| Pain: Eye pain | Worsen | 2.62 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 2.74 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 2.74 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Daytime drowsiness | Improves | -2.56 |
| Sleep: Problems staying asleep | Improves | -2.85 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -2.99 |
| ADHD | Worsen | 3.73 |
| Allergies | Worsen | 3.54 |
| Alzheimer's disease | Improves | -2.96 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -1.31 |
| Ankylosing spondylitis | Worsen | 4.51 |
| Asthma | Worsen | 2.74 |
| Atherosclerosis | Worsen | 3.3 |
| Autism | Worsen | 3.36 |
| Barrett esophagus cancer | Improves | -1.45 |
| Brain Trauma | Worsen | 1.62 |
| Carcinoma | Worsen | 0.79 |
| Celiac Disease | Worsen | 2.74 |
| Chronic Fatigue Syndrome | Worsen | 0.11 |
| Chronic Kidney Disease | Improves | -3.14 |
| Chronic urticaria (Hives) | Worsen | 3.92 |
| Colorectal Cancer | Worsen | 3.53 |
| Coronary artery disease | Improves | -3.09 |
| Crohn's Disease | Worsen | 4.21 |
| cystic fibrosis | Worsen | 2.99 |
| Depression | Worsen | 3.66 |
| Epilepsy | Worsen | 4.01 |
| gallstone disease (gsd) | Worsen | 2.9 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -3.23 |
| Generalized anxiety disorder | Worsen | 2.54 |
| Gout | Worsen | 2.96 |
| Graves' disease | Improves | -2.88 |
| Hashimoto's thyroiditis | Worsen | 2.76 |
| High Blood Pressure | Worsen | 2.79 |
| Histamine Issues | Worsen | 2.46 |
| Histamine Issues From Ubiome | Worsen | 2.27 |
| hypercholesterolemia (High Cholesterol) | Improves | -3.19 |
| Hyperlipidemia (High Blood Fats) | Improves | -1.93 |
| hypertension (High Blood Pressure | Worsen | 3.71 |
| IgA nephropathy (IgAN) | Improves | -2.52 |
| Inflammatory Bowel Disease | Worsen | 3.34 |
| Insomnia | Worsen | 3.54 |
| Irritable Bowel Syndrome | Improves | -4.28 |
| Juvenile idiopathic arthritis | Worsen | 1.8 |
| Liver Cirrhosis | Improves | -4.15 |
| ME/CFS with IBS | Worsen | 3.5 |
| ME/CFS without IBS | Worsen | 3.62 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 4.41 |
| Multiple system atrophy (MSA) | Improves | -2.9 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -1.34 |
| Obesity | Worsen | 2.47 |
| Osteoporosis | Improves | -3 |
| Parkinson's Disease | Worsen | 3.54 |
| Psoriasis | Worsen | 2.63 |
| Rheumatoid arthritis | Improves | -1.89 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.52 |
| Rosacea | Worsen | 4.15 |
| Schizophrenia | Worsen | 3.41 |
| Sclerosis | Improves | -2.76 |
| Sjögren syndrome | Worsen | 3.46 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 3.11 |
| Stress / posttraumatic stress disorder | Improves | -3.35 |
| Systemic Lupus Erythematosus | Improves | -4.01 |
| Type 1 Diabetes | Improves | -3.28 |
| Type 2 Diabetes | Improves | -3.73 |
| Ulcerative colitis | Worsen | 3.24 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.