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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
DePaul University Fatigue Questionnaire : Allergies	Worsen	3.35
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	2.8
DePaul University Fatigue Questionnaire : Fatigue	Worsen	2.8
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	2.8
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	2.8

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-2.72
Allergies	Improves	-1.94
Ankylosing spondylitis	Worsen	2.82
Asthma	Worsen	0
Atherosclerosis	Improves	-1.45
Autism	Worsen	1.45
Barrett esophagus cancer	Worsen	1.46
Carcinoma	Improves	-2.63
Celiac Disease	Improves	-2.48
Chronic Fatigue Syndrome	Improves	-3.96
Chronic Kidney Disease	Improves	-2.45
Colorectal Cancer	Worsen	2.43
Crohn's Disease	Worsen	3.05
cystic fibrosis	Improves	-3.57
Depression	Improves	-2.53
Epilepsy	Improves	-2.72
Fibromyalgia	Improves	-2.72
gallstone disease (gsd)	Worsen	2.8
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-1.46
Hashimoto's thyroiditis	Improves	-3.28
High Blood Pressure	Improves	-2.45
Histamine Issues	Improves	-2.79
Histamine Issues From Ubiome	Improves	-2.72
Hyperlipidemia (High Blood Fats)	Improves	-3.51
IgA nephropathy (IgAN)	Improves	-2.72
Inflammatory Bowel Disease	Improves	-2.88
Irritable Bowel Syndrome	Improves	-3.34
Liver Cirrhosis	Improves	-2.19
ME/CFS with IBS	Worsen	0
ME/CFS without IBS	Improves	-2.43
Multiple Sclerosis	Improves	-3.58
Multiple system atrophy (MSA)	Worsen	2.72
Obesity	Worsen	3.21
Osteoporosis	Worsen	2.72
Parkinson's Disease	Worsen	3.31
Psoriasis	Improves	-2.23
Rheumatoid arthritis	Improves	-3.95
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-3.04
Rosacea	Improves	-2.72
Schizophrenia	Worsen	3.38
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-3.99
Stress / posttraumatic stress disorder	Improves	-3.42
Systemic Lupus Erythematosus	Improves	-3.77
Type 1 Diabetes	Improves	-1.45
Type 2 Diabetes	Improves	-2.31
Ulcerative colitis	Worsen	2.57

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.