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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 60-70	Improves	-1.71
Asymptomatic: No Health Issues	Worsen	1.67
Autonomic Manifestations: cardiac arrhythmias	Improves	-3.57
Autonomic Manifestations: irritable bowel syndrome	Improves	-1.71
Blood Type: O Positive	Worsen	2.69
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Improves	-1.71
Comorbid-Mouth: Dry Mouth	Improves	-2.74
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	Improves	-1.71
Comorbid: Constipation and Explosions (not diarrohea)	Improves	-1.71
Comorbid: Fibromyalgia	Improves	-3.62
Comorbid: High Anxiety	Worsen	2.69
Comorbid: Hypothyroidism	Improves	-1.71
Comorbid: Snoring (NOT Sleep Apnea	Improves	-1.71
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Worsen	1.67
General: Myalgia (pain)	Improves	-1.71
Immune Manifestations: Bloating	Improves	-1.71
Immune Manifestations: Constipation	Improves	-1.71
Immune Manifestations: general malaise	Improves	-1.71
Infection: Human Herpesvirus 6 (HHV6)	Improves	-0.19
Joint: Stiffness and swelling	Improves	-1.71
Neurocognitive: Unable to focus vision and/or attention	Improves	-1.71
Neuroendocrine Manifestations: subnormal body temperature	Improves	-1.71
Neuroendocrine Manifestations: sweating episodes	Improves	-1.71
Neuroendocrine: Feeling like you have a low temperature	Improves	-2.74
Neurological-Audio: Tinnitus (ringing in ear)	Improves	-1.71
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Improves	-1.71
Neurological-Sleep: Night Sweats	Improves	-1.71
Neurological-Vision: inability to focus eye/vision	Improves	-1.71
Neurological: Difficulty reading	Improves	-1.71
Neurological: emotional overload	Improves	-2.74
Neurological: Executive Decision Making (Difficulty making)	Improves	-1.71
Neurological: fasciculations	Worsen	1.58
Neurological: High degree of Empathy before onset	Improves	-2.74
Neurological: Impairment of concentration	Improves	-1.71
Neurological: Short-term memory issues	Improves	-2.74
Neurological: Spatial instability and disorientation	Improves	-2.74
Official Diagnosis: Allergic Rhinitis (Hay Fever)	Worsen	2.96
Official Diagnosis: Autoimmune Disease	Worsen	2.18
Official Diagnosis: Mast Cell Dysfunction	Improves	-1.71
Pain: Chest pain	Worsen	2.96
Pain: Sensitivity to pain	Improves	-0.23
Post-exertional malaise: Difficulty reading after mild physical or mental activity	Improves	-1.71
Post-exertional malaise: General	Improves	-2.74
Post-exertional malaise: Mentally tired after the slightest effort	Improves	-2.74
Post-exertional malaise: Physically drained or sick after mild activity	Improves	-2.74
Post-exertional malaise: Post-exertional malaise	Improves	-2.74
Post-exertional malaise: Rapid cognitive fatigability,	Improves	-2.74
Post-exertional malaise: Worsening of symptoms after mild mental activity	Improves	-2.74
Sleep: Daytime drowsiness	Improves	-1.71
Sleep: Problems staying asleep	Improves	-1.71
Sleep: Waking up early in the morning (e.g. 3 AM)	Improves	-1.71

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
ADHD	Worsen	3.63
Allergies	Improves	-2.86
Alzheimer's disease	Improves	-2.96
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Improves	-2.74
Ankylosing spondylitis	Worsen	3.56
Asthma	Improves	-2.01
Atherosclerosis	Improves	-4.3
Autism	Improves	-4.02
Barrett esophagus cancer	Worsen	0
Brain Trauma	Worsen	1.33
Carcinoma	Improves	-3.63
Celiac Disease	Improves	-3.65
Chronic Fatigue Syndrome	Improves	-3.02
Chronic Kidney Disease	Worsen	2.23
Chronic urticaria (Hives)	Improves	-3.06
Colorectal Cancer	Improves	-2.96
Crohn's Disease	Improves	-4.25
cystic fibrosis	Improves	-3.5
Depression	Worsen	4.95
Epilepsy	Improves	-3.23
Fibromyalgia	Worsen	1.71
Functional constipation / chronic idiopathic constipation	Worsen	2.96
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-2.6
Generalized anxiety disorder	Improves	-3.55
Gout	Worsen	2.96
Graves' disease	Improves	-3
Hashimoto's thyroiditis	Improves	-2.42
High Blood Pressure	Worsen	3.37
Histamine Issues	Improves	-4.44
hypercholesterolemia (High Cholesterol)	Worsen	3.14
Hyperlipidemia (High Blood Fats)	Improves	-2.96
IgA nephropathy (IgAN)	Worsen	3.06
Inflammatory Bowel Disease	Improves	-4.71
Irritable Bowel Syndrome	Improves	-2.78
Liver Cirrhosis	Improves	-3.81
ME/CFS with IBS	Worsen	0
ME/CFS without IBS	Worsen	1.82
Mood Disorders	Worsen	2.74
Multiple Sclerosis	Improves	-4.06
Multiple system atrophy (MSA)	Improves	-1.55
neuropsychiatric disorders (PANDAS, PANS)	Improves	-2.42
NonCeliac Gluten Sensitivity	Worsen	2.06
Obesity	Worsen	2.57
Osteoporosis	Improves	-2.41
Parkinson's Disease	Worsen	1.39
Psoriasis	Improves	-3.78
Rheumatoid arthritis	Improves	-3.66
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-3.8
Rosacea	Worsen	2.69
Schizophrenia	Improves	-0.64
Sjögren syndrome	Improves	-3.38
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-4.36
Stress / posttraumatic stress disorder	Improves	-3.22
Systemic Lupus Erythematosus	Worsen	1.85
Type 1 Diabetes	Worsen	2.47
Type 2 Diabetes	Worsen	3.81
Ulcerative colitis	Improves	-3.52

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.