We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 2.87 |
| Comorbid: Inflammatory bowel disease | Improves | -2.87 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -2.87 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -2.87 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -2.87 |
| Gender: Female | Worsen | 2.83 |
| General: Fatigue | Worsen | 2.87 |
| Immune Manifestations: Bloating | Worsen | 2.87 |
| Immune Manifestations: Constipation | Worsen | 2.87 |
| Neuroendocrine: Lack of appetite | Worsen | 2.87 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 2.83 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 2.87 |
| Onset: 2010-2020 | Worsen | 2.87 |
| Pain: Joint pain | Worsen | 2.83 |
| Sleep: Daytime drowsiness | Worsen | 2.87 |
| Sleep: Problems staying asleep | Worsen | 2.87 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Alzheimer's disease | Improves | -2.83 |
| Ankylosing spondylitis | Worsen | 1.19 |
| Atherosclerosis | Worsen | 3.48 |
| Autism | Worsen | 3.89 |
| Bipolar Disorder | Worsen | 2.43 |
| Carcinoma | Improves | -2.83 |
| Celiac Disease | Improves | -2.92 |
| Chronic Fatigue Syndrome | Improves | -2.43 |
| Colorectal Cancer | Improves | -3.66 |
| COVID-19 | Improves | -2.43 |
| Crohn's Disease | Improves | -2.83 |
| cystic fibrosis | Improves | -3.57 |
| High Blood Pressure | Worsen | 2.83 |
| Histamine Issues | Improves | -2.43 |
| Inflammatory Bowel Disease | Improves | -2.43 |
| Irritable Bowel Syndrome | Improves | -3.25 |
| Liver Cirrhosis | Worsen | 3.9 |
| ME/CFS without IBS | Improves | -2.43 |
| Multiple Sclerosis | Improves | -3.99 |
| Obesity | Improves | -3.92 |
| Parkinson's Disease | Improves | -3.49 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.71 |
| Schizophrenia | Improves | -2.83 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.21 |
| Systemic Lupus Erythematosus | Improves | -2.83 |
| Type 1 Diabetes | Improves | -2.83 |
| Type 2 Diabetes | Improves | -3.49 |
| Ulcerative colitis | Worsen | 3.31 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.