[Clostridium] paradoxum Details: NCBI 29346, gram-negative or unknown [species]

| [Clostridium] paradoxum| ATCC 51510| CIP 105527| Clostridium paradoxum| Clostridium paradoxum Li et al. 1993| DSM 7308| strain JW-YL-7

1. Gut microbiota: Clostridium species are common members of the human gut microbiota, where they play important roles in fermentation, metabolism, and immune regulation. While some Clostridium species are considered beneficial and contribute to gut health, others may be opportunistic pathogens under certain conditions. Clostridium paradoxum has been detected in the human gut microbiota, but its specific role in gut health and disease is not well understood.

2. Disease association: While Clostridium paradoxum is not commonly associated with human disease, some Clostridium species are known to cause infections in humans, particularly in individuals with underlying health conditions or compromised immune systems. Clostridium difficile, for example, is a well-known pathogen that can cause antibiotic-associated diarrhea and pseudomembranous colitis. Clostridium botulinum produces botulinum toxin, which can cause botulism, a severe and potentially life-threatening illness.

3. Production of metabolites: Clostridium species are capable of producing a wide range of metabolites, including short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate, as well as various toxins and enzymes. These metabolites can have diverse effects on host physiology, immune function, and gut barrier integrity. While some metabolites produced by Clostridium species may be beneficial, others may be harmful and contribute to disease development.

4. Opportunistic infections: Clostridium species, including Clostridium paradoxum, have been implicated in opportunistic infections, particularly in healthcare settings. Infections with Clostridium species can occur following surgical procedures, invasive medical interventions, or prolonged antibiotic therapy. Clostridium difficile infections, in particular, have become a significant public health concern due to the emergence of antibiotic-resistant strains and the associated morbidity and mortality.

5. Potential probiotic properties: While most research on Clostridium species has focused on their pathogenic potential, some strains may have probiotic properties and could be beneficial for gut health. Clostridium species capable of producing SCFAs, such as butyrate, may have anti-inflammatory and immunomodulatory effects in the gut. However, further research is needed to evaluate the safety and efficacy of Clostridium-based probiotics for human use.

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for [Clostridium] paradoxum

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	0.09			10	20	1	29	15	15	7.1	10	20	25 %ile	50 %ile
biomesight	50.38	0	50	10	990	0	2839	218.6	70	1337.2	0	250	3.3 %ile	97.2 %ile
thryve	58.48	0	34	18	79	0	258	62.9	37	99.3	9	89	11.2 %ile	91.2 %ile

External Reference Ranges for [Clostridium] paradoxum

[Clostridium] paradoxum (NCBI 29346) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age

Statistic by Lab Source for [Clostridium] paradoxum

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
BiomeSight	53.171 %	0.019 %	0.071 %	1576.0	2964
BiomeSightRdp	6.452 %	0.002 %	0.001 %	2.0	31
Thryve	60.36 %	0.006 %	0.009 %	839.0	1390

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