Symptoms with KEGG Enzymes Relationships

The number of KEGG Enzymes found to have a P-value of 0.01 or less (z-score: +/-2.58) are shown. The higher the z-score

See Technical Note on Methodology

SymptomsRelationshipsSamples1Highest Z-score
Age: 0-10 185 37 4.84
Age: 10-20 26 22 -2.69
Age: 20-30 111 79 3.79
Age: 30-40 197 162 4.93
Age: 40-50 332 108 5.31
Age: 50-60 208 81 5.31
Age: 60-70 367 172 9.6
Asymptomatic: Live in house with person with probable microbiome dysfunction 64 66 3.28
Asymptomatic: Minor Health Issues (a few symptoms only) 176 54 6.99
Asymptomatic: No Health Issues 285 203 5.36
Autism: High Functioning 715 20 5.46
Autism: More Abnormal Body Posturing or Facial Expressions 15 6 -7.78
Autism: More Abnormal Tone of Voice 17 6 -5.5
Autism: More Avoidance of Eye Contact or Poor Eye Contact 46 8 4.06
Autism: More Behavioral Disturbances 449 10 10.77
Autism: More Decrease in Speaking 114 13 7.09
Autism: More deficits in Language Comprehension 108 13 6.15
Autism: More Flat or Monotonous Speech 18 6 -3.89
Autism: More Inappropriate Social Interaction 241 8 11.93
Autism: More Intense Focus on One Topic 207 11 8.08
Autism: More Repeating Words or Phrases 201 8 4.14
Autism: More Repetitive Movements 436 7 11.96
Autism: More Sleep Disturbances 183 13 4.68
Autism: More Unusual Responses to an Unexpected Event 168 9 10.42
Autism: Official Diagnosis 171 122 6.23
Autism: Spectrum (not full) 299 13 6.93
Autonomic Manifestations: bladder dysfunction 86 23 5.46
Autonomic Manifestations: cardiac arrhythmias 225 42 6.44
Autonomic Manifestations: Chemical Smelling Urine (atypical) 538 12 5.26
Autonomic Manifestations: Cortisol disorders or irregularity 107 63 4.74
Autonomic Manifestations: delayed postural hypotension 60 18 3.94
Autonomic Manifestations: exertional dyspnea 145 23 3.81
Autonomic Manifestations: extreme pallor 704 14 4.69
Autonomic Manifestations: irritable bowel syndrome 303 288 4.04
Autonomic Manifestations: light-headedness 197 97 5.18
Autonomic Manifestations: nausea 334 65 4.49
Autonomic Manifestations: Neurally mediated hypotension (NMH) 57 6 3.95
Autonomic Manifestations: Orthostatic intolerance 234 108 4.88
Autonomic Manifestations: palpitations 125 70 4.63
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) 202 66 5.55
Autonomic Manifestations: urinary frequency dysfunction 137 71 4.27
Autonomic: Blurred or tunnel vision after standing 197 38 5.96
Autonomic: Dizziness or fainting 170 77 5.67
Autonomic: Graying or blacking out after standing 393 28 9.4
Autonomic: Heart rate increase after standing 132 82 4.87
Autonomic: Inability to tolerate an upright position 267 100 5.24
Autonomic: Irregular heartbeats 148 110 4.34
Autonomic: Nausea 165 54 6.48
Autonomic: Ocassional Tachycardia (Rapid heart beat) 52 65 7.51
Autonomic: Shortness of breath 39 73 3.23
Autonomic: Vasovagal syncope (easy fainting) 48 14 -2.58
Blood Type: A Negative 36 12 5.24
Blood Type: A Positive 299 61 5.6
Blood Type: B Positive 73 18 12.19
Blood Type: FUT2 secretor 252 8 5.21
Blood Type: O Negative 28 17 3.48
Blood Type: O Positive 299 204 10.5
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding 187 260 4.97
Comorbid-Mouth: Butterfly-shaped rash across cheeks and nose 165 8 3.26
Comorbid-Mouth: Dry Mouth 657 84 4.91
Comorbid-Mouth: Gingivits / Gum Disease 275 40 6.01
Comorbid-Mouth: Mouth Sores 146 51 5.45
Comorbid-Mouth: Periradicular periodontitis inflammatory / chronic lesion around roots of teeth 55 15 4.2
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome 266 196 5.67
Comorbid-Mouth: Ulcers (mouth) 24 16 3.5
Comorbid: Cancer 42 7 11.61
Comorbid: Carbohydrate intolerance 51 16 4.3
Comorbid: Chronic Halitosis 35 9 3.75
Comorbid: Constipation and Diarrohea (not explosions) 20 37 -2.59
Comorbid: Constipation and Explosions (not diarrohea) 272 150 10.5
Comorbid: Crohn's Disease 195 12 7.19
Comorbid: Electromagnetic Sensitivity (EMF) 42 23 4.13
Comorbid: Fibromyalgia 192 71 6.76
Comorbid: High Anxiety 307 207 11.2
Comorbid: Histamine or Mast Cell issues 112 235 4.93
Comorbid: Hyperthyroidism 152 8 6.2
Comorbid: Hypothyroidism 204 200 5.35
Comorbid: Inflammatory bowel disease 215 132 5.37
Comorbid: Malodor 713 6 5.93
Comorbid: Methylation issues (MTHFR) 574 61 4.61
Comorbid: Migraine 427 49 7.32
Comorbid: Mold Sensitivity / Exposure 59 73 4.28
Comorbid: Mood Swings 240 40 4.4
Comorbid: Multiple Chemical Sensitivity 243 88 4.83
Comorbid: Panic Attacks 200 18 3.51
Comorbid: Raynaud’s syndrome (Skin discoloration) 107 19 6.38
Comorbid: Reactive Hypoglicemia 63 8 2.81
Comorbid: Restless Leg 48 49 4.43
Comorbid: Salicylate sensitive 189 10 6.68
Comorbid: Sleep Apnea Diagnosis 883 10 10.28
Comorbid: Small intestinal bacterial overgrowth (SIBO) 154 122 3.49
Comorbid: Snoring (NOT Sleep Apnea 276 153 6.99
Comorbid: Sugars cause sleep or cognitive issues 50 10 -2.64
Comorbid: Ulcerative colitis 81 14 5.24
Condition: Acne 947 26 6.36
Condition: Asthma 441 10 5.54
Condition: Brain Trauma 83 7 5.28
Condition: Generalized anxiety disorder 173 10 5.05
Condition: ME/CFS with IBS 124 50 4.59
Condition: ME/CFS without IBS 139 24 2.81
Condition: Non-alcoholic Fatty Liver Disease 148 8 5.5
Condition: Non-Celiac Gluten Sensitivity 170 25 3.6
Condition: Osteoarthritis 33 7 6.27
Condition: Post-Traumatic Stress Disorder 618 18 6.45
Condition: Psoriasis 23 11 5.79
DePaul University Fatigue Questionnaire : Abdomen pain 104 43 4.73
DePaul University Fatigue Questionnaire : Abnormal sensitivity to light 90 38 4.26
DePaul University Fatigue Questionnaire : Absent-mindedness 68 45 3.47
DePaul University Fatigue Questionnaire : Allergies 357 67 4.8
DePaul University Fatigue Questionnaire : Anxiety/tension 128 73 4.17
DePaul University Fatigue Questionnaire : Blurred Vision 42 23 3.63
DePaul University Fatigue Questionnaire : Chemical sensitivity 94 33 4.57
DePaul University Fatigue Questionnaire : Chest pain 44 11 11.06
DePaul University Fatigue Questionnaire : Chilled or shivery 36 21 3.91
DePaul University Fatigue Questionnaire : Concern with driving 99 20 5.62
DePaul University Fatigue Questionnaire : Confusion/disorientation 33 20 3.68
DePaul University Fatigue Questionnaire : Depression 135 49 4.71
DePaul University Fatigue Questionnaire : Difficulty comprehending Information 254 43 4.28
DePaul University Fatigue Questionnaire : Difficulty falling asleep 737 50 3.83
DePaul University Fatigue Questionnaire : Difficulty finding the right word 914 75 4.49
DePaul University Fatigue Questionnaire : Difficulty following things 160 37 4.51
DePaul University Fatigue Questionnaire : Difficulty reasoning things out 821 31 4.64
DePaul University Fatigue Questionnaire : Difficulty recalling information 58 52 3.39
DePaul University Fatigue Questionnaire : Difficulty retaining information 58 47 3.26
DePaul University Fatigue Questionnaire : Difficulty staying asleep 109 51 4.54
DePaul University Fatigue Questionnaire : Dizziness 53 28 6.07
DePaul University Fatigue Questionnaire : Does physical activity make you feel better 64 18 5.03
DePaul University Fatigue Questionnaire : Does physical activity make you feel no effect 50 6 6.21
DePaul University Fatigue Questionnaire : Does physical activity make you feel worse 229 65 3.68
DePaul University Fatigue Questionnaire : Easily irritated 1027 56 5.03
DePaul University Fatigue Questionnaire : Eye pain 34 25 4.98
DePaul University Fatigue Questionnaire : Fatigue 822 219 5.75
DePaul University Fatigue Questionnaire : Feel unsteady on feet 186 22 4.06
DePaul University Fatigue Questionnaire : Feeling like you have a temperature 24 20 -2.6
DePaul University Fatigue Questionnaire : Fever & Chills 31 12 3.94
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say 127 52 3.25
DePaul University Fatigue Questionnaire : Frequently get words or numbers in the wrong order 309 22 3.81
DePaul University Fatigue Questionnaire : Frequently loose train of thought 793 38 4.19
DePaul University Fatigue Questionnaire : Headaches 184 39 5.55
DePaul University Fatigue Questionnaire : Hot or Cold spells 56 32 5.33
DePaul University Fatigue Questionnaire : Impaired Memory & concentration 705 174 5.59
DePaul University Fatigue Questionnaire : Mood swings 580 36 5
DePaul University Fatigue Questionnaire : Muscle Pain (i.e., sensations of pain or aching in your muscles. This does not include weakness or pain in other areas such as joints) 312 53 4.61
DePaul University Fatigue Questionnaire : Muscle weakness 306 52 5.69
DePaul University Fatigue Questionnaire : Nausea 47 30 5
DePaul University Fatigue Questionnaire : Need to have to focus on one thing at a time 218 52 4.74
DePaul University Fatigue Questionnaire : Need to nap during each day 302 38 3.82
DePaul University Fatigue Questionnaire : New trouble with math 107 14 4.42
DePaul University Fatigue Questionnaire : Night sweats 31 17 2.66
DePaul University Fatigue Questionnaire : Pain in Multiple Joints without Swelling or Redness 35 35 5.12
DePaul University Fatigue Questionnaire : Poor Appetite 36 18 3.81
DePaul University Fatigue Questionnaire : Poor hand to eye coodination 126 8 10.69
DePaul University Fatigue Questionnaire : Post-exertional malaise, feeling worse after doing activities that require either physical or mental exertion 1084 69 4.59
DePaul University Fatigue Questionnaire : Racing heart 159 23 4.42
DePaul University Fatigue Questionnaire : Rash 154 16 3.58
DePaul University Fatigue Questionnaire : Ringing in the Ears 40 46 2.88
DePaul University Fatigue Questionnaire : Sensitivity to Alcohol 35 43 4.66
DePaul University Fatigue Questionnaire : Shortness of breath 117 33 5.86
DePaul University Fatigue Questionnaire : Slow to react 57 27 7.34
DePaul University Fatigue Questionnaire : Slowness of thought 122 45 4.5
DePaul University Fatigue Questionnaire : Sore Throat 34 28 4.9
DePaul University Fatigue Questionnaire : Sweating hands 206 9 6.12
DePaul University Fatigue Questionnaire : Temperature lower than normal 55 35 4.16
DePaul University Fatigue Questionnaire : Tense muscles 39 29 4.2
DePaul University Fatigue Questionnaire : Tingling feeling 138 22 3.53
DePaul University Fatigue Questionnaire : Trouble expressing thoughts 60 31 3.87
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired 396 200 5.41
DePaul University Fatigue Questionnaire : Upset stomach 42 34 3.84
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) 124 49 2.87
DePaul University Fatigue Questionnaire : Weight change 84 27 2.61
Gender: Female 181 226 3.5
Gender: Male 68 319 3.63
General: Depression 125 209 4.33
General: Fatigue 495 345 5.02
General: Headaches 429 239 4.86
General: Heavy feeling in arms and legs 134 56 2.59
General: Myalgia (pain) 259 161 3.55
General: Sinus issues with headaches 95 95 3.2
Immune Manifestations: Abdominal Pain 208 256 4.57
Immune Manifestations: Alcohol Intolerant 219 243 4.83
Immune Manifestations: Bloating 172 350 3.95
Immune Manifestations: Chronic Flatus / Flatulence / gas 66 32 3.03
Immune Manifestations: Constipation 196 282 4.87
Immune Manifestations: Diarrhea 184 123 4.74
Immune Manifestations: general malaise 248 256 4.13
Immune Manifestations: Genitorinary / Nocturia - Urinary issues 82 34 4.71
Immune Manifestations: Hair loss 119 139 5.22
Immune Manifestations: High Altitude Intolerance 105 33 4.98
Immune Manifestations: hives 165 30 6.04
Immune Manifestations: Inflammation (General) 140 183 5.04
Immune Manifestations: Inflammation of skin, eyes or joints 71 164 3.25
Immune Manifestations: medication sensitivities. 740 109 4.92
Immune Manifestations: Mucus in the stool 109 137 4.23
Immune Manifestations: new food sensitivities 181 114 5.28
Immune Manifestations: recurrent flu-like symptoms 38 87 2.8
Immune Manifestations: tender lymph nodes 488 79 2.94
Immune Manifestations: Thick blood / Hypercoagulation 30 40 4.04
Immune Manifestations: vomiting 51 7 2.66
Immune: Chronic Sinusitis 34 42 2.67
Immune: Flu-like symptoms 130 81 3.12
Immune: Recurrent Sore throat 43 90 3.29
Immune: Sensitivity to smell/food/medication/chemicals 239 148 3.07
Immune: Tender / sore lymph nodes 126 87 3.76
Immune: Viral infections with prolonged recovery periods 122 64 3.57
Infection: Coxsackie 45 24 4.8
Infection: Epstein-Barr virus 187 184 3.89
Infection: Human Herpesvirus 6 (HHV6) 137 124 5.2
Infection: Lyme 54 39 7.42
Infection: Mycoplasma 78 97 4.77
Infection: Parasite - Other 37 65 3.07
Infection: Parasites - Giardia 41 7 5.42
Infection: Parvovirus 102 9 6.03
Infection: Varicella Zoster Virus 179 8 3.97
Joint: Redness 142 39 5.19
Joint: Stiffness and swelling 259 214 6.47
Joint: Sudden and severe episodes of pain 138 39 20.44
Joint: Tenderness 191 140 5.59
Neurocognitive: Absent-mindedness or forgetfulness 281 294 4.28
Neurocognitive: Brain Fog 100 391 3.69
Neurocognitive: Can only focus on one thing at a time 263 285 4.83
Neurocognitive: Difficulty expressing thoughts 91 153 4.25
Neurocognitive: Difficulty paying attention for a long period of time 305 297 4.57
Neurocognitive: Difficulty understanding things 76 117 4.02
Neurocognitive: Feeling disoriented 68 85 5.19
Neurocognitive: Problems remembering things 216 297 5.16
Neurocognitive: Slowness of thought 564 279 5.12
Neurocognitive: Unable to focus vision and/or attention 200 244 5.21
Neuroendocrine Manifestations: abnormal appetite 221 59 9.46
Neuroendocrine Manifestations: Air Hunger 85 54 3.96
Neuroendocrine Manifestations: cold extremities 368 185 5.73
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) 720 92 3.45
Neuroendocrine Manifestations: Excessive adrenaline 110 50 5.54
Neuroendocrine Manifestations: intolerance of extremes of heat and cold 62 166 3.55
Neuroendocrine Manifestations: Laboured breathing 63 16 -2.59
Neuroendocrine Manifestations: loss of adaptability 31 43 8.39
Neuroendocrine Manifestations: marked diurnal fluctuation 27 16 2.65
Neuroendocrine Manifestations: marked weight change 64 93 3.89
Neuroendocrine Manifestations: Muscle weakness 221 155 3.59
Neuroendocrine Manifestations: Neuralgia 191 32 11.6
Neuroendocrine Manifestations: Painful menstrual periods 60 32 5.15
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) 202 102 5.14
Neuroendocrine Manifestations: Poor gut motility 349 44 4.27
Neuroendocrine Manifestations: Rapid muscular fatiguability 93 113 8.27
Neuroendocrine Manifestations: recurrent feelings of feverishness 84 49 3.41
Neuroendocrine Manifestations: subnormal body temperature 832 213 5.01
Neuroendocrine Manifestations: sweating episodes 144 147 3.8
Neuroendocrine Manifestations: worsening of symptoms with stress. 424 308 3.28
Neuroendocrine: Alcohol intolerance 278 216 5.28
Neuroendocrine: Chills or shivers 122 38 4.05
Neuroendocrine: Cold limbs (e.g. arms, legs hands) 198 110 5.19
Neuroendocrine: Feeling hot or cold for no reason 217 106 3.06
Neuroendocrine: Feeling like you have a high temperature 195 58 3.48
Neuroendocrine: Feeling like you have a low temperature 100 50 5.11
Neuroendocrine: Lack of appetite 105 43 14.07
Neuroendocrine: Lost or gained weight without trying 184 77 3.95
Neuroendocrine: Sweating hands 83 33 5.64
Neuroendocrine: Temperature fluctuations throughout the day 34 52 4.25
Neurological-Audio: hypersensitivity to noise 358 261 5.29
Neurological-Audio: Tinnitus (ringing in ear) 220 273 4.38
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) 332 197 5.46
Neurological-Sleep: Inability for deep (delta) sleep 54 100 3.25
Neurological-Sleep: Insomnia 254 247 5.13
Neurological-Sleep: Night Sweats 79 109 4.61
Neurological-Sleep: Prolonged Sleep 206 24 6.01
Neurological-Sleep: Sleep Apnea 105 56 3.97
Neurological-Sleep: Sleep Reversal 124 15 3.74
Neurological-Sleep: Vivid Dreams/Nightmares 40 70 4.06
Neurological-Vision: Acquired or exertional dyslexia 322 10 10.86
Neurological-Vision: Blurred Vision 353 101 7.14
Neurological-Vision: Impaired Depth Perceptions 60 23 4.55
Neurological-Vision: inability to focus eye/vision 461 194 6.45
Neurological-Vision: photophobia (Light Sensitivity) 369 227 6.89
Neurological: Ataxia (lack of volunatary muscle control) 83 19 6.36
Neurological: Cognitive/Sensory Overload 128 138 18.16
Neurological: Confusion 296 68 6.19
Neurological: Difficulty processing information (Understanding) 391 129 5.22
Neurological: Difficulty reading 381 222 6.54
Neurological: Disorientation 77 51 5.64
Neurological: Dysautonomia 298 86 5.38
Neurological: emotional overload 391 141 5.59
Neurological: Executive Decision Making (Difficulty making) 332 234 5.42
Neurological: fasciculations 381 56 5.54
Neurological: High degree of Empathy before onset 190 55 8.52
Neurological: Impairment of concentration 807 274 5.71
Neurological: Joint hypermobility 210 138 5.42
Neurological: Myoclonic jerks or seizures 248 34 4.87
Neurological: Neuropathy 153 45 4.25
Neurological: Seasonal Affective Disorder (SAD) 105 104 5.05
Neurological: Short-term memory issues 634 149 4.66
Neurological: Slowed speech 171 83 5.13
Neurological: Spatial instability and disorientation 84 44 4.05
Neurological: Word-finding problems 162 203 4.94
Official Diagnosis: Allergic Rhinitis (Hay Fever) 128 184 5.11
Official Diagnosis: Asperger's Syndrome 176 6 17.95
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD) 26 32 4.08
Official Diagnosis: Autoimmune Disease 205 130 6
Official Diagnosis: Celiac Disease 193 22 6.67
Official Diagnosis: Chronic Fatigue Syndrome (CFS/ME) 46 147 3.7
Official Diagnosis: Crohn's Disease 190 16 11.53
Official Diagnosis: Depression 430 57 4.82
Official Diagnosis: Dermatitis (all types) 136 9 3.35
Official Diagnosis: Diabetes Type 1 1016 6 23.92
Official Diagnosis: Fibromyalgia 184 45 4.05
Official Diagnosis: Gastroesophageal reflux disease (GERD) 61 22 -2.6
Official Diagnosis: High Blood Pressure (Hypertension) 66 14 9.43
Official Diagnosis: Hypercholesterolemia (High Cholesterol) 106 9 7.44
Official Diagnosis: Inflammatory Bowel Disease (IBD) 99 19 4.48
Official Diagnosis: Irritable Bowel Syndrome 117 265 4.15
Official Diagnosis: Mast Cell Dysfunction 294 175 6.98
Official Diagnosis: Metabolic Syndrome 479 15 3.68
Official Diagnosis: Mood Disorders 189 33 4.93
Official Diagnosis: Osteoporosis 243 15 4.66
Official Diagnosis: Rheumatoid arthritis 54 14 23.83
Official Diagnosis: Ulcerative colitis 107 19 6.01
Onset: 1970-1980 78 8 5.59
Onset: 1980-1990 66 22 5.99
Onset: 1990-2000 133 25 4
Onset: 2000-2010 95 82 4.3
Onset: 2010-2020 200 240 4.75
Onset: Gradual 226 122 5.12
Onset: less than 02 years since onset 33 31 3.31
Onset: less than 04 years since onset 41 45 3.63
Onset: less than 08 years since onset 68 38 3.38
Onset: less than 16 years since onset 38 52 5.41
Onset: less than 32 years since onset 860 35 4.66
Onset: over 31 years since onset 68 19 5.45
Onset: Sudden 105 27 4.13
Other: Deep cracks in heels (heel fissures) 84 12 4.75
Other: Sensitivity to mold 50 85 3.16
Other: Sensitivity to vibrations 648 37 4.74
Pain: Aching of the eyes or behind the eyes 86 66 3.98
Pain: Chest pain 50 38 4.15
Pain: Eye pain 126 42 5.14
Pain: Joint pain 187 128 4.4
Pain: Myofascial pain 182 69 3.67
Pain: Pain or aching in muscles 96 118 3.91
Pain: Sensitivity to pain 143 145 5.26
Physical: African 472 6 7.06
Physical: Amalgam fillings 128 14 3.74
Physical: Appendix removed 52 8 6.3
Physical: Breastfed 143 22 3.36
Physical: Eastern European 42 12 3.79
Physical: Good Air Quality 53 6 2.88
Physical: Keto Diet 95 8 12.36
Physical: Long term (chronic) stress 161 36 4.48
Physical: Northern European 759 58 4.68
Physical: Organic Diet 150 22 3.5
Physical: Pets 270 30 3.57
Physical: Southern European 210 12 9.98
Physical: Steps Per Day < 2000 427 22 6.16
Physical: Steps Per Day 2000-4000 153 15 3.22
Physical: Steps Per Day 4000-8000 77 16 4.05
Physical: Steps Per Day 8000-16000 56 6 8.91
Physical: Tonsils removed 60 13 3.88
Physical: Work-Sitting 354 47 7.25
Post-exertional malaise: Difficulty reading after mild physical or mental activity 79 129 2.68
Post-exertional malaise: General 223 125 4.92
Post-exertional malaise: Inappropriate loss of physical and mental stamina, 159 167 2.7
Post-exertional malaise: Mentally tired after the slightest effort 47 108 4.24
Post-exertional malaise: Muscle fatigue after mild physical activity 46 171 3.71
Post-exertional malaise: Next-day soreness after everyday activities 76 133 4.77
Post-exertional malaise: Physically drained or sick after mild activity 189 136 3.4
Post-exertional malaise: Physically tired after minimum exercise 93 181 3.87
Post-exertional malaise: Post-exertional malaise 35 172 3.46
Post-exertional malaise: Rapid cognitive fatigability, 112 131 4.66
Post-exertional malaise: Rapid muscular fatigability, 174 111 3.96
Post-exertional malaise: Worsening of symptoms after mild mental activity 365 99 4.28
Post-exertional malaise: Worsening of symptoms after mild physical activity 40 174 3.68
Sleep: Daytime drowsiness 138 257 5.09
Sleep: Need to nap daily 65 87 -2.62
Sleep: Problems falling asleep 50 130 3.73
Sleep: Problems staying asleep 199 258 5.23
Sleep: Sleeping all day and staying awake all night 37 24 3.97
Sleep: Unrefreshed sleep 247 311 4.64
Sleep: Waking up early in the morning (e.g. 3 AM) 164 264 4.8
1 This is the effective sample count based on clustering.

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