Symptoms with KEGG Module Relationships

The number of KEGG Module found to have a P-value of 0.01 or less (z-score: +/-2.58) are shown. The higher the z-score

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SymptomsRelationshipsSamples1Highest Z-score
Age: 0-10 13 36 3.93
Age: 10-20 3 22 5.25
Age: 20-30 9 78 4.23
Age: 30-40 46 159 3.49
Age: 40-50 24 108 4.27
Age: 50-60 6 77 3.31
Age: 60-70 9 174 3.95
Asymptomatic: Live in house with person with probable microbiome dysfunction 18 66 -2.67
Asymptomatic: Minor Health Issues (a few symptoms only) 17 54 3.78
Asymptomatic: No Health Issues 17 203 2.83
Autism: High Functioning 61 19 5.73
Autism: More Abnormal Body Posturing or Facial Expressions 4 6 3.92
Autism: More Avoidance of Eye Contact or Poor Eye Contact 5 8 2.99
Autism: More Behavioral Disturbances 53 9 9.34
Autism: More Decrease in Speaking 5 12 4.02
Autism: More deficits in Language Comprehension 45 12 5.36
Autism: More Flat or Monotonous Speech 1 6 2.63
Autism: More Inappropriate Social Interaction 55 7 11.79
Autism: More Intense Focus on One Topic 56 10 7.62
Autism: More Repeating Words or Phrases 48 7 6.27
Autism: More Repetitive Movements 56 6 10.3
Autism: More Sleep Disturbances 46 13 6.09
Autism: More Unusual Responses to an Unexpected Event 56 8 7.53
Autism: Official Diagnosis 9 121 4.56
Autism: Spectrum (not full) 16 13 8.12
Autonomic Manifestations: bladder dysfunction 2 23 4.41
Autonomic Manifestations: cardiac arrhythmias 7 42 3.16
Autonomic Manifestations: Chemical Smelling Urine (atypical) 12 12 7.11
Autonomic Manifestations: Cortisol disorders or irregularity 2 43 3.48
Autonomic Manifestations: delayed postural hypotension 1 6 4.2
Autonomic Manifestations: exertional dyspnea 14 23 4.13
Autonomic Manifestations: extreme pallor 15 14 -2.58
Autonomic Manifestations: irritable bowel syndrome 12 286 3.78
Autonomic Manifestations: light-headedness 13 95 7.89
Autonomic Manifestations: nausea 7 65 -2.72
Autonomic Manifestations: Orthostatic intolerance 14 109 4.61
Autonomic Manifestations: palpitations 19 70 3.14
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) 30 65 2.77
Autonomic Manifestations: urinary frequency dysfunction 23 69 4.54
Autonomic: Blurred or tunnel vision after standing 17 38 4.21
Autonomic: Dizziness or fainting 6 76 3.56
Autonomic: Graying or blacking out after standing 33 28 6.12
Autonomic: Inability to tolerate an upright position 17 100 4.38
Autonomic: Irregular heartbeats 9 109 6.96
Autonomic: Nausea 12 52 5.9
Autonomic: Ocassional Tachycardia (Rapid heart beat) 6 65 3
Autonomic: Vasovagal syncope (easy fainting) 1 13 -2.69
Blood Type: A Negative 2 12 -2.64
Blood Type: A Positive 25 61 5.14
Blood Type: B Positive 4 16 2.8
Blood Type: FUT2 secretor 38 8 8.13
Blood Type: O Positive 24 202 5.94
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding 8 253 3.95
Comorbid-Mouth: Butterfly-shaped rash across cheeks and nose 8 8 -2.61
Comorbid-Mouth: Dry Mouth 42 82 3.36
Comorbid-Mouth: Gingivits / Gum Disease 4 38 2.76
Comorbid-Mouth: Mouth Sores 8 51 3.77
Comorbid-Mouth: Periradicular periodontitis inflammatory / chronic lesion around roots of teeth 1 6 3.75
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome 13 194 4.38
Comorbid-Mouth: Ulcers (mouth) 2 6 2.9
Comorbid: Carbohydrate intolerance 3 14 -2.61
Comorbid: Chronic Halitosis 1 7 -2.91
Comorbid: Constipation and Diarrohea (not explosions) 4 12 -2.77
Comorbid: Constipation and Explosions (not diarrohea) 23 150 5.3
Comorbid: Crohn's Disease 18 12 6.37
Comorbid: Fibromyalgia 28 69 2.87
Comorbid: High Anxiety 17 205 6.8
Comorbid: Histamine or Mast Cell issues 6 214 3.49
Comorbid: Hyperthyroidism 3 8 3.47
Comorbid: Hypothyroidism 9 200 4.59
Comorbid: Inflammatory bowel disease 18 132 4.84
Comorbid: Malodor 7 6 3.77
Comorbid: Methylation issues (MTHFR) 35 58 3.35
Comorbid: Migraine 35 49 4
Comorbid: Mold Sensitivity / Exposure 23 73 -2.58
Comorbid: Mood Swings 53 39 4.63
Comorbid: Multiple Chemical Sensitivity 36 88 3.92
Comorbid: Panic Attacks 43 18 3.02
Comorbid: Raynaud’s syndrome (Skin discoloration) 8 19 5.85
Comorbid: Reactive Hypoglicemia 8 8 -2.59
Comorbid: Restless Leg 10 47 -2.61
Comorbid: Salicylate sensitive 49 10 2.67
Comorbid: Sleep Apnea Diagnosis 42 9 3.43
Comorbid: Small intestinal bacterial overgrowth (SIBO) 42 122 4.52
Comorbid: Snoring (NOT Sleep Apnea 21 153 4.95
Comorbid: Sugars cause sleep or cognitive issues 2 9 -2.71
Comorbid: Ulcerative colitis 1 14 -2.8
Condition: Acne 33 26 4.66
Condition: Asthma 54 10 5.17
Condition: Brain Trauma 6 6 -2.65
Condition: Generalized anxiety disorder 41 9 10.58
Condition: ME/CFS with IBS 19 49 8.37
Condition: ME/CFS without IBS 27 24 6.41
Condition: Non-alcoholic Fatty Liver Disease 33 8 3.82
Condition: Non-Celiac Gluten Sensitivity 14 24 4.51
Condition: Osteoarthritis 10 7 3.06
Condition: Post-Traumatic Stress Disorder 10 16 6.38
Condition: Psoriasis 2 10 4.71
DePaul University Fatigue Questionnaire : Abdomen pain 11 42 2.86
DePaul University Fatigue Questionnaire : Abnormal sensitivity to light 7 37 4.02
DePaul University Fatigue Questionnaire : Absent-mindedness 11 44 4.02
DePaul University Fatigue Questionnaire : Allergies 40 66 5.07
DePaul University Fatigue Questionnaire : Anxiety/tension 15 71 4.52
DePaul University Fatigue Questionnaire : Blurred Vision 10 22 3.43
DePaul University Fatigue Questionnaire : Chemical sensitivity 17 33 -2.61
DePaul University Fatigue Questionnaire : Concern with driving 14 19 4.04
DePaul University Fatigue Questionnaire : Depression 9 48 2.95
DePaul University Fatigue Questionnaire : Difficulty comprehending Information 10 43 4.3
DePaul University Fatigue Questionnaire : Difficulty falling asleep 11 50 3.06
DePaul University Fatigue Questionnaire : Difficulty finding the right word 17 75 4.66
DePaul University Fatigue Questionnaire : Difficulty following things 11 37 4.15
DePaul University Fatigue Questionnaire : Difficulty reasoning things out 8 31 4.28
DePaul University Fatigue Questionnaire : Difficulty recalling information 11 52 4.51
DePaul University Fatigue Questionnaire : Difficulty retaining information 4 47 3.92
DePaul University Fatigue Questionnaire : Difficulty staying asleep 15 50 4.05
DePaul University Fatigue Questionnaire : Dizziness 3 27 3
DePaul University Fatigue Questionnaire : Does physical activity make you feel better 2 17 -2.68
DePaul University Fatigue Questionnaire : Does physical activity make you feel no effect 2 6 -3.55
DePaul University Fatigue Questionnaire : Does physical activity make you feel worse 20 64 4.39
DePaul University Fatigue Questionnaire : Easily irritated 34 56 5.59
DePaul University Fatigue Questionnaire : Eye pain 1 23 -2.67
DePaul University Fatigue Questionnaire : Fatigue 49 215 5.71
DePaul University Fatigue Questionnaire : Feel unsteady on feet 3 22 3.22
DePaul University Fatigue Questionnaire : Fever & Chills 2 10 3.58
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say 8 52 3.67
DePaul University Fatigue Questionnaire : Frequently get words or numbers in the wrong order 2 21 3.33
DePaul University Fatigue Questionnaire : Frequently loose train of thought 13 38 4.23
DePaul University Fatigue Questionnaire : Hot or Cold spells 3 31 4.2
DePaul University Fatigue Questionnaire : Impaired Memory & concentration 48 174 5.44
DePaul University Fatigue Questionnaire : Mood swings 15 34 4.15
DePaul University Fatigue Questionnaire : Muscle Pain (i.e., sensations of pain or aching in your muscles. This does not include weakness or pain in other areas such as joints) 41 52 4.16
DePaul University Fatigue Questionnaire : Muscle weakness 22 51 4.57
DePaul University Fatigue Questionnaire : Nausea 4 12 11.89
DePaul University Fatigue Questionnaire : Need to have to focus on one thing at a time 13 50 3.93
DePaul University Fatigue Questionnaire : Need to nap during each day 12 37 -2.59
DePaul University Fatigue Questionnaire : Night sweats 3 17 2.73
DePaul University Fatigue Questionnaire : Pain in Multiple Joints without Swelling or Redness 2 18 2.6
DePaul University Fatigue Questionnaire : Poor Appetite 1 8 3.15
DePaul University Fatigue Questionnaire : Poor hand to eye coodination 17 8 7.28
DePaul University Fatigue Questionnaire : Post-exertional malaise, feeling worse after doing activities that require either physical or mental exertion 71 68 4.96
DePaul University Fatigue Questionnaire : Racing heart 1 10 3.07
DePaul University Fatigue Questionnaire : Rash 6 15 3.03
DePaul University Fatigue Questionnaire : Ringing in the Ears 13 45 3.92
DePaul University Fatigue Questionnaire : Sensitivity to Alcohol 1 35 2.79
DePaul University Fatigue Questionnaire : Shortness of breath 6 32 4.04
DePaul University Fatigue Questionnaire : Slowness of thought 9 44 4.24
DePaul University Fatigue Questionnaire : Sore Throat 1 28 2.63
DePaul University Fatigue Questionnaire : Sweating hands 8 9 -2.68
DePaul University Fatigue Questionnaire : Temperature lower than normal 11 35 3.97
DePaul University Fatigue Questionnaire : Tense muscles 9 28 3.1
DePaul University Fatigue Questionnaire : Tingling feeling 12 22 -2.59
DePaul University Fatigue Questionnaire : Trouble expressing thoughts 1 31 3.19
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired 52 197 4.51
DePaul University Fatigue Questionnaire : Upset stomach 6 30 -2.65
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) 18 49 3.28
DePaul University Fatigue Questionnaire : Weight change 18 26 -2.59
Gender: Female 18 224 3.37
Gender: Male 1 26 2.76
General: Depression 33 207 4.36
General: Fatigue 22 341 3.74
General: Headaches 19 237 4.65
General: Heavy feeling in arms and legs 11 55 2.79
General: Myalgia (pain) 27 160 3.23
General: Sinus issues with headaches 11 85 -2.59
Immune Manifestations: Abdominal Pain 11 254 4.17
Immune Manifestations: Alcohol Intolerant 11 240 4.02
Immune Manifestations: Bloating 3 174 3.59
Immune Manifestations: Chronic Flatus / Flatulence / gas 10 31 4.12
Immune Manifestations: Constipation 9 279 4.87
Immune Manifestations: Diarrhea 15 123 -2.63
Immune Manifestations: general malaise 11 255 2.94
Immune Manifestations: Genitorinary / Nocturia - Urinary issues 7 33 3.28
Immune Manifestations: Hair loss 54 138 4.76
Immune Manifestations: High Altitude Intolerance 5 33 3.6
Immune Manifestations: hives 35 30 -2.6
Immune Manifestations: Inflammation (General) 41 182 4.19
Immune Manifestations: Inflammation of skin, eyes or joints 46 164 4.96
Immune Manifestations: medication sensitivities. 17 109 3.88
Immune Manifestations: Mucus in the stool 9 136 3.29
Immune Manifestations: new food sensitivities 32 113 5.12
Immune Manifestations: recurrent flu-like symptoms 3 86 2.84
Immune Manifestations: tender lymph nodes 15 79 2.77
Immune Manifestations: Thick blood / Hypercoagulation 8 13 -3.72
Immune Manifestations: vomiting 3 7 -2.9
Immune: Chronic Sinusitis 6 42 -2.7
Immune: Flu-like symptoms 17 81 2.78
Immune: Sensitivity to smell/food/medication/chemicals 25 148 -2.6
Immune: Tender / sore lymph nodes 5 86 3.5
Immune: Viral infections with prolonged recovery periods 29 64 -2.61
Infection: Coxsackie 19 24 3.87
Infection: Epstein-Barr virus 12 184 3.52
Infection: Human Herpesvirus 6 (HHV6) 13 121 3.8
Infection: Lyme 2 32 -2.63
Infection: Mycoplasma 3 97 2.83
Infection: Parasite - Other 10 65 5.03
Infection: Parasites - Giardia 2 7 -2.73
Infection: Parvovirus 25 9 3.74
Infection: Varicella Zoster Virus 6 8 -2.85
Joint: Redness 16 39 5.22
Joint: Stiffness and swelling 13 214 4.96
Joint: Sudden and severe episodes of pain 14 39 8.6
Joint: Tenderness 28 140 4.86
Neurocognitive: Absent-mindedness or forgetfulness 12 293 3.4
Neurocognitive: Brain Fog 8 32 3.19
Neurocognitive: Can only focus on one thing at a time 4 140 2.93
Neurocognitive: Difficulty expressing thoughts 5 119 3.25
Neurocognitive: Difficulty paying attention for a long period of time 7 297 4.45
Neurocognitive: Difficulty understanding things 7 117 -2.62
Neurocognitive: Feeling disoriented 5 82 2.6
Neurocognitive: Problems remembering things 5 252 3.82
Neurocognitive: Slowness of thought 17 279 4.94
Neurocognitive: Unable to focus vision and/or attention 12 243 3.64
Neuroendocrine Manifestations: abnormal appetite 12 59 3.4
Neuroendocrine Manifestations: Air Hunger 4 46 4.25
Neuroendocrine Manifestations: cold extremities 13 183 5.15
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) 45 91 -2.59
Neuroendocrine Manifestations: Excessive adrenaline 13 49 7.75
Neuroendocrine Manifestations: intolerance of extremes of heat and cold 8 162 2.75
Neuroendocrine Manifestations: loss of adaptability 3 37 3.58
Neuroendocrine Manifestations: marked diurnal fluctuation 3 16 -2.99
Neuroendocrine Manifestations: marked weight change 2 90 3.05
Neuroendocrine Manifestations: Muscle weakness 19 154 2.88
Neuroendocrine Manifestations: Neuralgia 5 32 5.8
Neuroendocrine Manifestations: Painful menstrual periods 9 12 3.44
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) 12 102 4.48
Neuroendocrine Manifestations: Poor gut motility 28 42 4.33
Neuroendocrine Manifestations: Rapid muscular fatiguability 20 112 2.64
Neuroendocrine Manifestations: recurrent feelings of feverishness 5 48 3.74
Neuroendocrine Manifestations: subnormal body temperature 18 213 7.42
Neuroendocrine Manifestations: sweating episodes 1 8 6.02
Neuroendocrine Manifestations: worsening of symptoms with stress. 12 307 3.11
Neuroendocrine: Alcohol intolerance 12 213 3.86
Neuroendocrine: Chills or shivers 11 38 -2.67
Neuroendocrine: Cold limbs (e.g. arms, legs hands) 10 109 2.82
Neuroendocrine: Feeling hot or cold for no reason 11 106 2.96
Neuroendocrine: Feeling like you have a high temperature 11 58 2.85
Neuroendocrine: Feeling like you have a low temperature 5 50 -2.73
Neuroendocrine: Lack of appetite 9 43 3.81
Neuroendocrine: Lost or gained weight without trying 20 77 -2.71
Neuroendocrine: Sweating hands 22 33 3.61
Neuroendocrine: Temperature fluctuations throughout the day 3 41 3.67
Neurological-Audio: hypersensitivity to noise 9 254 3.88
Neurological-Audio: Tinnitus (ringing in ear) 2 16 4.56
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) 13 196 7.58
Neurological-Sleep: Inability for deep (delta) sleep 2 96 2.63
Neurological-Sleep: Insomnia 9 243 4.37
Neurological-Sleep: Prolonged Sleep 3 22 4.33
Neurological-Sleep: Sleep Apnea 30 56 3.96
Neurological-Sleep: Sleep Reversal 2 15 2.68
Neurological-Sleep: Vivid Dreams/Nightmares 3 8 2.97
Neurological-Vision: Acquired or exertional dyslexia 28 10 8.16
Neurological-Vision: Blurred Vision 25 100 4.08
Neurological-Vision: Impaired Depth Perceptions 3 9 3.93
Neurological-Vision: inability to focus eye/vision 28 193 5.4
Neurological-Vision: photophobia (Light Sensitivity) 7 226 4.37
Neurological: Ataxia (lack of volunatary muscle control) 13 19 -2.62
Neurological: Cognitive/Sensory Overload 15 138 2.84
Neurological: Confusion 10 66 3.93
Neurological: Difficulty processing information (Understanding) 24 129 3.36
Neurological: Difficulty reading 17 222 4.88
Neurological: Disorientation 1 48 3.05
Neurological: Dysautonomia 4 86 3.37
Neurological: emotional overload 31 139 3.8
Neurological: Executive Decision Making (Difficulty making) 17 231 6.32
Neurological: fasciculations 20 56 4.06
Neurological: High degree of Empathy before onset 6 55 3.91
Neurological: Impairment of concentration 26 272 4.2
Neurological: Joint hypermobility 9 137 4.11
Neurological: Myoclonic jerks or seizures 24 34 2.8
Neurological: Neuropathy 7 20 2.82
Neurological: Seasonal Affective Disorder (SAD) 19 102 4.32
Neurological: Short-term memory issues 32 148 9.92
Neurological: Slowed speech 8 83 4.27
Neurological: Spatial instability and disorientation 4 43 -3.17
Neurological: Word-finding problems 3 159 3.47
Official Diagnosis: Allergic Rhinitis (Hay Fever) 12 184 4.35
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD) 8 32 2.83
Official Diagnosis: Autoimmune Disease 27 130 5.14
Official Diagnosis: Celiac Disease 10 21 3.51
Official Diagnosis: Chronic Fatigue Syndrome (CFS/ME) 8 11 -2.59
Official Diagnosis: Crohn's Disease 17 16 4.87
Official Diagnosis: Depression 12 56 3.52
Official Diagnosis: Dermatitis (all types) 17 8 -2.61
Official Diagnosis: Diabetes Type 1 70 6 18.83
Official Diagnosis: Fibromyalgia 6 11 -3.67
Official Diagnosis: High Blood Pressure (Hypertension) 3 14 3.55
Official Diagnosis: Hypercholesterolemia (High Cholesterol) 19 8 3.32
Official Diagnosis: Inflammatory Bowel Disease (IBD) 6 19 3.08
Official Diagnosis: Irritable Bowel Syndrome 6 264 4.06
Official Diagnosis: Mast Cell Dysfunction 24 175 5.65
Official Diagnosis: Metabolic Syndrome 8 14 -2.59
Official Diagnosis: Mood Disorders 55 33 4.4
Official Diagnosis: Osteoporosis 25 14 -2.65
Official Diagnosis: Rheumatoid arthritis 36 14 6.78
Official Diagnosis: Ulcerative colitis 1 19 -2.89
Onset: 1970-1980 14 8 6.28
Onset: 1980-1990 1 22 -2.86
Onset: 1990-2000 12 25 3.53
Onset: 2000-2010 5 82 2.98
Onset: 2010-2020 10 233 5.18
Onset: Gradual 16 121 4.41
Onset: less than 02 years since onset 7 27 3.46
Onset: less than 08 years since onset 7 36 -2.76
Onset: less than 16 years since onset 9 51 2.75
Onset: less than 32 years since onset 40 34 4.48
Onset: over 31 years since onset 9 19 4.63
Onset: Sudden 14 26 -2.63
Other: Deep cracks in heels (heel fissures) 17 12 5.82
Other: Sensitivity to mold 15 83 2.66
Other: Sensitivity to vibrations 13 37 2.63
Pain: Aching of the eyes or behind the eyes 3 64 2.98
Pain: Chest pain 2 11 3.62
Pain: Eye pain 11 41 2.91
Pain: Joint pain 20 128 3.88
Pain: Myofascial pain 18 69 3.55
Pain: Pain or aching in muscles 22 118 4.36
Pain: Sensitivity to pain 9 145 5.03
Physical: African 1 6 3.04
Physical: Amalgam fillings 25 14 6.61
Physical: Appendix removed 5 8 4.97
Physical: Breastfed 18 21 4.7
Physical: Good Air Quality 11 6 3.42
Physical: Keto Diet 19 8 4.46
Physical: Long term (chronic) stress 8 36 5.15
Physical: Northern European 29 58 3.72
Physical: Organic Diet 6 21 3.57
Physical: Pets 17 30 4.42
Physical: Southern European 23 12 5.89
Physical: Steps Per Day < 2000 6 21 4.01
Physical: Steps Per Day 2000-4000 27 14 3.69
Physical: Steps Per Day 4000-8000 12 16 4.7
Physical: Tonsils removed 27 13 -2.64
Physical: Work-Sitting 22 46 5.58
Post-exertional malaise: Difficulty reading after mild physical or mental activity 13 129 3.29
Post-exertional malaise: General 11 125 3.07
Post-exertional malaise: Inappropriate loss of physical and mental stamina, 20 167 -2.7
Post-exertional malaise: Muscle fatigue after mild physical activity 8 170 3.34
Post-exertional malaise: Next-day soreness after everyday activities 2 6 3.34
Post-exertional malaise: Physically drained or sick after mild activity 14 136 3.85
Post-exertional malaise: Physically tired after minimum exercise 5 180 3.44
Post-exertional malaise: Post-exertional malaise 7 172 3.14
Post-exertional malaise: Rapid cognitive fatigability, 14 130 3.04
Post-exertional malaise: Rapid muscular fatigability, 22 111 3.28
Post-exertional malaise: Worsening of symptoms after mild mental activity 28 98 4.66
Post-exertional malaise: Worsening of symptoms after mild physical activity 3 174 2.75
Sleep: Daytime drowsiness 10 255 4.19
Sleep: Need to nap daily 4 26 -2.6
Sleep: Problems falling asleep 7 130 3.8
Sleep: Problems staying asleep 10 254 3.79
Sleep: Sleeping all day and staying awake all night 6 9 2.65
Sleep: Unrefreshed sleep 19 310 3.64
Sleep: Waking up early in the morning (e.g. 3 AM) 8 261 4.25
1 This is the effective sample count based on clustering.
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