Lawsonia Details: NCBI 41707, gram-negative or unknown [genus]

| Lawsonia| Lawsonia McOrist et al. 1995

  1. Animal Pathogen:

    • Lawsonia intracellularis is primarily considered a veterinary pathogen. It causes a disease known as proliferative enteropathy in animals, particularly in swine (pigs) and horses.
  2. Proliferative Enteropathy:

    • In affected animals, Lawsonia intracellularis is associated with proliferative enteropathy, which is characterized by thickening of the intestinal mucosa and can lead to clinical signs such as diarrhea, weight loss, and reduced growth.
  3. Transmission in Animals:

    • Transmission of Lawsonia intracellularis among animals typically occurs through the fecal-oral route. Contaminated water, feed, or fomites can contribute to the spread of the bacterium within animal populations.
  4. Zoonotic Potential:

    • Lawsonia intracellularis is generally not considered a zoonotic pathogen, meaning it is not known to cause disease in humans. The primary concern is related to its impact on animal health and the agricultural industry.
  5. Impacts on Animal Production:

    • In agricultural settings, Lawsonia intracellularis infections in swine can have economic implications due to reduced growth rates and increased mortality rates in affected animals. Control measures may include vaccination and management practices.

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Statistics NCBI Data Punk End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Lawsonia

Using Kaltoft-Moldrup Heuristic Using uploaded data for Lawsonia

Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)
LabKM LowKM Percentile LowKM HighKM Percentile HighLab LowLab HighMean MedianStandard DeviationBox Plot LowBox Plot High
* 2 11.1 %ile 643 77.8 %ile 0 597 140.7 20 232.9 2 643
biomesight 10 7.1 %ile 40 85.7 %ile 3 38 20.8 20 9 10 40
thorne 1 0 %ile 8 100 %ile 0 8 3.6 2 2.4 1 8
thryve 22 11.2 %ile 150 90 %ile 0 3857 181.6 58 1875 0 162
Lab Suggestions for Lawsonia
Lawsonia (NCBI 41707) per million
Low Boundary High Boundary Low Boundary %age High Boundary %age Lab Samples
0 5000 0 0.5 Metagenomics
Statistic by Lab Source for Lawsonia
These desired values are reported from the lab reports
Lab Frequency Seen Average Standard Deviation Sample Count Lab Samples
BiomeSight 0.703 %   0.002 %  0.001 % 20.0 2844
BiomeSightRdp 3.125 %   0.002 %  % 1.0 32
CerbaLab 100 %   0.028 %  0.033 % 3.0 3
es-xenogene 10.345 %   0.004 %  0.005 % 3.0 29
Thorne 41.176 %   0 %  0 % 35.0 85
Thryve 46.957 %   0.018 %  0.177 % 648.0 1380

Symptoms Associated with Lawsonia From Citizen Science Studies

Click on Impact for information if high or low levels are causing the impact

MagnitudeImpactSymptom
1 Reduces General: Fatigue
1 Reduces Post-exertional malaise: Inappropriate loss of physical and mental stamina,
1 Reduces Sleep: Unrefreshed sleep
1 Reduces Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)
1 Reduces General: Myalgia (pain)
1 Reduces General: Headaches
1 Reduces Neurological: Confusion
1 Reduces Neurological: Impairment of concentration
1 Reduces Neurological: Short-term memory issues
1 Reduces Neurological: Disorientation
1 Reduces Neurological: Difficulty processing information (Understanding)
1 Increases Neurological: Word-finding problems
1 Increases Neurological-Vision: inability to focus eye/vision
1 Reduces Neurological-Vision: photophobia (Light Sensitivity)
1 Reduces Neurological-Audio: hypersensitivity to noise
1 Reduces Neurological: emotional overload
1 Reduces Autonomic Manifestations: Orthostatic intolerance
1 Reduces Autonomic Manifestations: light-headedness
1 Reduces Autonomic Manifestations: nausea
1 Reduces Autonomic Manifestations: irritable bowel syndrome
1 Increases Autonomic Manifestations: urinary frequency dysfunction
1 Increases Post-exertional malaise: Rapid muscular fatigability,
1 Reduces Post-exertional malaise: Rapid cognitive fatigability,
1 Reduces Post-exertional malaise: General
1 Reduces Neuroendocrine Manifestations: subnormal body temperature
1 Reduces Neuroendocrine Manifestations: sweating episodes
1 Increases Neuroendocrine Manifestations: cold extremities
1 Reduces Neuroendocrine Manifestations: intolerance of extremes of heat and cold
1 Increases Neuroendocrine Manifestations: marked weight change
1 Reduces Neuroendocrine Manifestations: worsening of symptoms with stress.
1 Reduces Immune Manifestations: recurrent flu-like symptoms
1 Reduces Immune Manifestations: general malaise
1 Reduces Immune Manifestations: new food sensitivities
1 Increases Immune Manifestations: medication sensitivities.
1 Reduces Onset: Gradual
1 Reduces Virus: Epstein-Barr virus
1 Reduces Infection: Mycoplasma
1 Reduces Comorbid: Multiple Chemical Sensitivity
1 Reduces Comorbid: Fibromyalgia
1 Increases Comorbid: Hypothyroidism
1 Reduces Neurological: Dysautonomia
1 Reduces Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)
1 Increases Neuroendocrine Manifestations: Muscle weakness
1 Reduces Neurological: Cognitive/Sensory Overload
1 Reduces Neurological: Slowed speech
1 Reduces Neurological-Sleep: Insomnia
1 Reduces Neurological-Sleep: Vivid Dreams/Nightmares
1 Reduces Immune Manifestations: Bloating
1 Reduces Immune Manifestations: Abdominal Pain
1 Increases Immune Manifestations: Constipation
1 Reduces Immune Manifestations: Diarrhea
1 Reduces Neurological: Difficulty reading
1 Reduces Neurological: Joint hypermobility
1 Increases Onset: less than 02 years since onset
1 Increases Onset: less than 16 years since onset
1 Increases Immune Manifestations: Alcohol Intolerant
1 Reduces Neurological-Audio: Tinnitus (ringing in ear)
1 Reduces Neurological-Sleep: Night Sweats
1 Reduces Neurological-Sleep: Sleep Apnea
1 Reduces Neurological: Seasonal Affective Disorder (SAD)
1 Reduces Infection: Parasite - Other
1 Increases Comorbid: Mold Sensitivity / Exposure
1 Increases Neurological-Vision: Blurred Vision
1 Reduces Virus: Human Herpesvirus 6 positive (HHV6)
1 Reduces Immune Manifestations: Hair loss
1 Reduces Neurological-Sleep: Inability for deep (delta) sleep
1 Reduces Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome
1 Reduces Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding
1 Reduces Comorbid: Small intestinal bacterial overgrowth (SIBO)
1 Reduces Comorbid: Inflammatory bowel disease
1 Reduces Comorbid: Restless Leg
1 Increases Asymptomatic: No Health Issues
1 Reduces Comorbid: Histamine or Mast Cell issues
1 Reduces Neurological: Executive Decision Making (Difficulty making)
1 Increases Neuroendocrine Manifestations: Rapid muscular fatiguability
1 Reduces Gender: Male
1 Increases Gender: Female
1 Reduces Onset: 2010-2020
1 Reduces Onset: 2000-2010
1 Increases Age: 0-10
1 Reduces Age: 10-20
1 Reduces Age: 20-30
1 Reduces Age: 30-40
1 Increases Age: 40-50
1 Reduces Age: 50-60
1 Increases Age: 60-70
1 Reduces Sleep: Need to nap daily
1 Reduces Sleep: Problems falling asleep
1 Reduces Sleep: Problems staying asleep
1 Reduces Sleep: Waking up early in the morning (e.g. 3 AM)
1 Increases Sleep: Daytime drowsiness
1 Reduces Pain: Pain or aching in muscles
1 Reduces Pain: Joint pain
1 Reduces Pain: Sensitivity to pain
1 Reduces Neuroendocrine: Lost or gained weight without trying
1 Reduces Neuroendocrine: Lack of appetite
1 Reduces Neuroendocrine: Cold limbs (e.g. arms, legs hands)
1 Reduces Neuroendocrine: Feeling hot or cold for no reason
1 Reduces Neuroendocrine: Alcohol intolerance
1 Reduces Immune: Recurrent Sore throat
1 Increases Immune: Tender / sore lymph nodes
1 Reduces Immune: Flu-like symptoms
1 Increases Immune: Sensitivity to smell/food/medication/chemicals
1 Reduces Immune: Viral infections with prolonged recovery periods
1 Increases Other: Sensitivity to mold
1 Reduces Autonomic: Nausea
1 Reduces Autonomic: Shortness of breath
1 Reduces Autonomic: Dizziness or fainting
1 Reduces Autonomic: Irregular heartbeats
1 Reduces Autonomic: Heart rate increase after standing
1 Reduces Autonomic: Inability to tolerate an upright position
1 Reduces Neurocognitive: Problems remembering things
1 Reduces Neurocognitive: Difficulty paying attention for a long period of time
1 Reduces Neurocognitive: Difficulty expressing thoughts
1 Reduces Neurocognitive: Difficulty understanding things
1 Reduces Neurocognitive: Can only focus on one thing at a time
1 Reduces Neurocognitive: Unable to focus vision and/or attention
1 Increases Neurocognitive: Slowness of thought
1 Reduces Neurocognitive: Absent-mindedness or forgetfulness
1 Increases Neurocognitive: Feeling disoriented
1 Reduces Post-exertional malaise: Post-exertional malaise
1 Reduces Post-exertional malaise: Next-day soreness after everyday activities
1 Reduces Post-exertional malaise: Mentally tired after the slightest effort
1 Reduces Post-exertional malaise: Physically tired after minimum exercise
1 Increases Post-exertional malaise: Physically drained or sick after mild activity
1 Reduces Post-exertional malaise: Muscle fatigue after mild physical activity
1 Reduces Post-exertional malaise: Worsening of symptoms after mild physical activity
1 Reduces Post-exertional malaise: Worsening of symptoms after mild mental activity
1 Reduces Post-exertional malaise: Difficulty reading after mild physical or mental activity
1 Reduces Official Diagnosis: Autism
1 Reduces Official Diagnosis: Attention deficit hyperactivity disorder (ADHD)
1 Reduces Official Diagnosis: Autoimmune Disease
1 Increases Official Diagnosis: Chronic Fatigue Syndrome (CFS/ME)
1 Reduces Official Diagnosis: Depression
1 Reduces Official Diagnosis: Irritable Bowel Syndrome
1 Increases Joint: Stiffness and swelling
1 Reduces Joint: Tenderness
1 Increases Immune Manifestations: Mucus in the stool
1 Reduces Immune Manifestations: Inflammation of skin, eyes or joints
1 Reduces General: Depression
1 Reduces Neurocognitive: Brain Fog
1 Reduces Official Diagnosis: Mast Cell Dysfunction
1 Reduces Comorbid-Mouth: Ulcers (mouth)
1 Reduces Immune Manifestations: Inflammation (General)
1 Increases Comorbid: Methylation issues (MTHFR)
1 Reduces Blood Type: O Positive
1 Increases Blood Type: A Positive
1 Reduces General: Heavy feeling in arms and legs
1 Reduces General: Sinus issues with headaches
1 Reduces Comorbid: High Anxiety
1 Reduces Comorbid: Mood Swings
1 Increases Comorbid: Constipation and Explosions (not diarrohea)
1 Increases Comorbid: Constipation and Diarrohea (not explosions)
1 Increases Official Diagnosis: Allergic Rhinitis (Hay Fever)
1 Reduces Comorbid: Snoring (NOT Sleep Apnea
1 Reduces Comorbid: Migraine
1 Reduces Official Diagnosis: Gastroesophageal reflux disease (GERD)
1 Reduces Comorbid: Panic Attacks
1 Reduces DePaul University Fatigue Questionnaire : Upset stomach
1 Reduces DePaul University Fatigue Questionnaire : Abdomen pain
1 Increases DePaul University Fatigue Questionnaire : Weight change
1 Reduces DePaul University Fatigue Questionnaire : Poor Appetite
1 Reduces DePaul University Fatigue Questionnaire : Dizziness
1 Reduces DePaul University Fatigue Questionnaire : Ringing in the Ears
1 Reduces DePaul University Fatigue Questionnaire : Tense muscles
1 Reduces DePaul University Fatigue Questionnaire : Abnormal sensitivity to light
1 Reduces DePaul University Fatigue Questionnaire : Allergies
1 Reduces DePaul University Fatigue Questionnaire : Chemical sensitivity
1 Reduces DePaul University Fatigue Questionnaire : Muscle weakness
1 Reduces DePaul University Fatigue Questionnaire : Need to nap during each day
1 Reduces DePaul University Fatigue Questionnaire : Difficulty falling asleep
1 Reduces DePaul University Fatigue Questionnaire : Difficulty staying asleep
1 Reduces DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)
1 Reduces DePaul University Fatigue Questionnaire : Slowness of thought
1 Reduces DePaul University Fatigue Questionnaire : Absent-mindedness
1 Reduces DePaul University Fatigue Questionnaire : Difficulty reasoning things out
1 Reduces DePaul University Fatigue Questionnaire : Forgetting what you are trying to say
1 Increases DePaul University Fatigue Questionnaire : Difficulty finding the right word
1 Reduces DePaul University Fatigue Questionnaire : Difficulty following things
1 Reduces DePaul University Fatigue Questionnaire : Difficulty comprehending Information
1 Reduces DePaul University Fatigue Questionnaire : Need to have to focus on one thing at a time
1 Reduces DePaul University Fatigue Questionnaire : Frequently loose train of thought
1 Reduces DePaul University Fatigue Questionnaire : Trouble expressing thoughts
1 Reduces DePaul University Fatigue Questionnaire : Difficulty retaining information
1 Reduces DePaul University Fatigue Questionnaire : Difficulty recalling information
1 Reduces DePaul University Fatigue Questionnaire : Slow to react
1 Reduces DePaul University Fatigue Questionnaire : Anxiety/tension
1 Reduces DePaul University Fatigue Questionnaire : Easily irritated
1 Reduces DePaul University Fatigue Questionnaire : Depression
1 Reduces DePaul University Fatigue Questionnaire : Mood swings
1 Reduces DePaul University Fatigue Questionnaire : Does physical activity make you feel better
1 Reduces DePaul University Fatigue Questionnaire : Does physical activity make you feel worse
1 Reduces DePaul University Fatigue Questionnaire : Fatigue
1 Reduces DePaul University Fatigue Questionnaire : Muscle Pain (i.e., sensations of pain or aching in your muscles. This does not include weakness or pain in other areas such as joints)
1 Reduces DePaul University Fatigue Questionnaire : Impaired Memory & concentration
1 Increases DePaul University Fatigue Questionnaire : Sensitivity to Alcohol
1 Reduces DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired
1 Reduces DePaul University Fatigue Questionnaire : Post-exertional malaise, feeling worse after doing activities that require either physical or mental exertion
1 Reduces DePaul University Fatigue Questionnaire : Headaches
1 Reduces Condition: Post-Traumatic Stress Disorder
1 Reduces Condition: Generalized anxiety disorder
1 Increases Condition: Non-Celiac Gluten Sensitivity
1 Reduces Condition: ME/CFS with IBS
1 Reduces Condition: ME/CFS without IBS
1 Increases Physical: Northern European
1 Increases Physical: Long term (chronic) stress
1 Increases Physical: Breastfed
1 Increases Physical: Pets
1 Increases Physical: Organic Diet
1 Reduces Physical: Work-Sitting
1 Reduces Physical: Steps Per Day < 2000
1 Reduces Neuroendocrine Manifestations: Poor gut motility
1 Increases Autism: High Functioning
1 Reduces Immune Manifestations: Chronic Flatus / Flatulence / gas
1 Increases Neurocognitive: Aphantasia ( inability to visualize mental images)

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Data Contradictions β€” Limits of Certainity

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General Substance Specific Substance Effect
Amino Acid and similar punicic acid 1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar pyruvate 1 Studies recorded. The consensus is Increases📓, Click for details.
Antibiotics, Antivirals etc azithromycin,(antibiotic)s[CFS] 1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc florfenicol (antibiotic)s 1 Studies recorded. The consensus is Decreases📓, Click for details.
Common Supplements quercetin 1 Studies recorded. The consensus is Decreases📓, Click for details.
Common Supplements Tributyrin 1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style animal-based diet 1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style enriched butter diet 1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style high animal protein diet 1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style high saturated milk fat diet 1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style high-fat diets 2 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style high-protein diet 1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style high-saturated fat diet 1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style ketogenic diet 1 Studies recorded. The consensus is Increases📓, Click for details.
Drug or "Non-drug" florfenicol 1 Studies recorded. The consensus is Decreases📓, Click for details.
Drug or "Non-drug" nsaid 1 Studies recorded. The consensus is Increases📓, Click for details.
flavonoids, polyphenols etc quebracho 1 Studies recorded. The consensus is Decreases📓, Click for details.
flavonoids, polyphenols etc quercetin,resveratrol 2 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings) barley 3 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings) black raspberries 2 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings) extra virgin olive oil 1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings) grapes 1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings) high red meat 1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings) lard 1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings) milk-derived saturated,fat 1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings) pea (fiber, protein) 1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings) vegetarians 1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice berberine 1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice Bofutsushosan 1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice chamaemelum nobile,chamomile 1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice garlic (allium sativum) 1 Studies recorded. The consensus is Decreases📓, Click for details.
Miscellaneous, food additives, and other odd items bile (acid/salts) 2 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar chicory (prebiotic) 1 Studies recorded. The consensus is Decreases📓, Click for details.
Prebiotics and similar inulin (prebiotic) 4 Studies recorded. The consensus is Decreases📓, Click for details.
Prescription - Other proton-pump inhibitors (prescription) 1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics bacillus subtilis (probiotics) 1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics bifidobacterium animalis lactis (probiotics) 1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics bifidobacterium pseudocatenulatum,(probiotics) 1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics clostridium butyricum (probiotics),Miya,Miyarisan 1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics lactobacillus kefiri (NOT KEFIR) 1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics lactobacillus plantarum (probiotics) 4 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics lactobacillus rhamnosus gg (probiotics) 1 Studies recorded. The consensus is Decreases📓, Click for details.
Sugar and similar lactulose 1 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar iron 1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar vitamin a 1 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar Vitamin B9,folic acid 1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar zinc 1 Studies recorded. The consensus is Increases📓, Click for details.

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