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Intoxication and Impaired Judgment: Ethanol is a psychoactive substance that can cause intoxication when consumed in large quantities. It affects the central nervous system, leading to symptoms such as euphoria, impaired coordination, slurred speech, slowed reaction times, and altered judgment. Excessive alcohol consumption can impair decision-making abilities and increase the risk of accidents, injuries, and risky behaviors.
Addiction and Alcoholism: Chronic and excessive alcohol consumption can lead to alcohol dependence and addiction, known as alcoholism. Alcoholism is a serious medical condition characterized by compulsive drinking, tolerance (the need to consume more alcohol to achieve the desired effects), withdrawal symptoms when alcohol use is stopped, and interference with daily functioning. Alcohol addiction can have detrimental effects on physical health, mental well-being, relationships, and overall quality of life.
Liver Disease: Ethanol metabolism primarily occurs in the liver, where it is broken down into acetaldehyde and then further metabolized into acetate and other byproducts. Chronic alcohol consumption can cause liver damage and lead to various liver diseases, including fatty liver disease, alcoholic hepatitis, fibrosis, and cirrhosis. Cirrhosis is a progressive and irreversible condition characterized by the formation of scar tissue in the liver, impairing its function and potentially leading to liver failure.
Cardiovascular Effects: Moderate alcohol consumption may have cardiovascular benefits, such as increasing HDL (good) cholesterol levels and reducing the risk of heart disease and stroke. However, excessive alcohol intake can have adverse cardiovascular effects, including high blood pressure (hypertension), irregular heart rhythms (arrhythmias), cardiomyopathy (weakening of the heart muscle), and increased risk of hemorrhagic stroke.
Gastrointestinal Disorders: Alcohol consumption can irritate the lining of the stomach and intestines, leading to gastrointestinal issues such as gastritis (inflammation of the stomach lining), ulcers, and gastrointestinal bleeding. Heavy drinking is also associated with an increased risk of developing pancreatitis, an inflammation of the pancreas that can cause severe abdominal pain, digestive problems, and potentially life-threatening complications.
Neurological and Mental Health Effects: Chronic alcohol abuse can have significant neurological and mental health consequences, including cognitive impairment, memory problems, mood disorders (such as depression and anxiety), sleep disturbances, and increased risk of neurodegenerative diseases like dementia. Prolonged alcohol use can also lead to alcohol-induced brain damage and structural changes in the brain.
Cancer Risk: Alcohol consumption is associated with an increased risk of several types of cancer, including cancer of the mouth, throat, esophagus, liver, breast, and colon. The carcinogenic effects of alcohol are thought to be mediated by its metabolites, such as acetaldehyde, which can damage DNA and promote tumor formation.
Weakened Immune Function: Excessive alcohol consumption can weaken the immune system, making individuals more susceptible to infections and delaying the body's ability to heal from injuries and illnesses. Chronic alcohol abuse is associated with an increased risk of respiratory infections, pneumonia, tuberculosis, and other infectious diseases.
Nutritional Deficiencies: Alcohol interferes with the absorption and metabolism of essential nutrients, leading to nutritional deficiencies, particularly of vitamins and minerals such as vitamin B12, folate, thiamine, and magnesium. Chronic alcoholism can result in malnutrition, which can contribute to a range of health problems, including anemia, nerve damage, and weakened bones.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Akkermansia muciniphila | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 0.9 | -0.9 | |
| Allergies | 0.6 | 0.5 | 0.2 |
| Alzheimer's disease | 1.6 | 1.2 | 0.33 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.6 | 0.5 | 2.2 |
| Ankylosing spondylitis | 0.6 | 0.3 | 1 |
| Anorexia Nervosa | 0.6 | -0.6 | |
| Asthma | 1 | -1 | |
| Atherosclerosis | 0.5 | -0.5 | |
| Atrial fibrillation | 0.6 | 0.6 | 0 |
| Autism | 2.2 | 2.2 | 0 |
| Bipolar Disorder | 0.6 | 0.6 | 0 |
| Carcinoma | 0.6 | 0.6 | 0 |
| Celiac Disease | 0.6 | 0.5 | 0.2 |
| Cerebral Palsy | 1.1 | 1.1 | |
| Chronic Fatigue Syndrome | 0.6 | -0.6 | |
| Chronic Urticaria (Hives) | 0.5 | -0.5 | |
| Colorectal Cancer | 1.1 | -1.1 | |
| COVID-19 | 1.9 | 2.3 | -0.21 |
| Crohn's Disease | 1.5 | 1.7 | -0.13 |
| Depression | 1.9 | 2.5 | -0.32 |
| Epilepsy | 0.5 | 1.9 | -2.8 |
| Fibromyalgia | 0.8 | -0.8 | |
| Functional constipation / chronic idiopathic constipation | 0.2 | 0.6 | -2 |
| gallstone disease (gsd) | 0.6 | 0.6 | |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.2 | -0.2 | |
| Generalized anxiety disorder | 0.2 | 0.2 | |
| Graves' disease | 0.3 | 0.3 | |
| Hashimoto's thyroiditis | 0.5 | 0.6 | -0.2 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.6 | 0.6 | 0 |
| hypercholesterolemia (High Cholesterol) | 0.5 | -0.5 | |
| hyperglycemia | 0.3 | 1 | -2.33 |
| Hyperlipidemia (High Blood Fats) | 2.5 | 2.5 | |
| hypertension (High Blood Pressure | 1.7 | 0.5 | 2.4 |
| Hypoxia | 0.5 | 0.5 | |
| IgA nephropathy (IgAN) | 0.8 | 0.3 | 1.67 |
| Inflammatory Bowel Disease | 0.8 | 1 | -0.25 |
| Irritable Bowel Syndrome | 1.7 | 1.1 | 0.55 |
| Liver Cirrhosis | 1.1 | 1.1 | 0 |
| Long COVID | 1.9 | 0.9 | 1.11 |
| Low bone mineral density | 0.6 | 0.6 | |
| Lung Cancer | 0.2 | 0.5 | -1.5 |
| ME/CFS with IBS | 0.6 | -0.6 | |
| Metabolic Syndrome | 1.7 | 2.1 | -0.24 |
| Mood Disorders | 3 | 2.5 | 0.2 |
| multiple chemical sensitivity [MCS] | 0.5 | 0.5 | |
| Multiple Sclerosis | 1.5 | 0.8 | 0.88 |
| Multiple system atrophy (MSA) | 1 | 0.2 | 4 |
| Neuropathy (all types) | 0.5 | 0.5 | |
| neuropsychiatric disorders (PANDAS, PANS) | 0.3 | -0.3 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.3 | 0.5 | -0.67 |
| Obesity | 1.6 | 2.9 | -0.81 |
| obsessive-compulsive disorder | 0.6 | 1.1 | -0.83 |
| Osteoarthritis | 0.2 | -0.2 | |
| Osteoporosis | 0.9 | 0.5 | 0.8 |
| Parkinson's Disease | 1.8 | 1.2 | 0.5 |
| Polycystic ovary syndrome | 0.9 | 0.5 | 0.8 |
| Psoriasis | 1.1 | 0.8 | 0.38 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.1 | 1.1 | |
| Schizophrenia | 0.8 | 0.8 | |
| sensorineural hearing loss | 0.3 | -0.3 | |
| Sjögren syndrome | 0.6 | 0.6 | 0 |
| Sleep Apnea | 0.9 | 0.9 | |
| Stress / posttraumatic stress disorder | 0.5 | 0.5 | 0 |
| Systemic Lupus Erythematosus | 0.3 | 0.3 | |
| Tourette syndrome | 0.5 | 0.5 | |
| Type 1 Diabetes | 0.6 | 0.6 | |
| Type 2 Diabetes | 1.7 | 1.6 | 0.06 |
| Ulcerative colitis | 1 | -1 | |
| Unhealthy Ageing | 0.5 | -0.5 |
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