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🍽️ gabapentin,(prescription)

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  1. Seizure Control: Gabapentin is effective in controlling various types of seizures, including partial seizures and generalized seizures, either as a monotherapy or as an adjunctive therapy along with other antiepileptic drugs. It works by stabilizing electrical activity in the brain, thereby reducing the occurrence and severity of seizures.

  2. Neuropathic Pain Relief: Gabapentin is commonly prescribed for the management of neuropathic pain conditions, such as diabetic neuropathy, postherpetic neuralgia (nerve pain following shingles), and peripheral neuropathy. It can alleviate pain symptoms by modulating the activity of certain neurotransmitters involved in pain signaling pathways.

  3. Fibromyalgia: Gabapentin may also be used off-label for the treatment of fibromyalgia, a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, and other symptoms. It can help reduce pain intensity and improve overall functioning in some individuals with fibromyalgia.

  4. Migraine Prophylaxis: Some studies suggest that gabapentin may be effective as a preventive treatment for migraine headaches, particularly in individuals who experience frequent or refractory migraines. It may help reduce the frequency, duration, and severity of migraine attacks.

  5. Anxiety and Mood Disorders: Gabapentin may have anxiolytic (anxiety-reducing) and mood-stabilizing effects in certain individuals with anxiety disorders, bipolar disorder, or other mood disorders. It is sometimes prescribed off-label as an adjunctive treatment for these conditions, although evidence supporting its efficacy is limited.

  6. Sleep Disorders: Gabapentin may improve sleep quality and promote sleep continuity in individuals with certain sleep disorders, such as insomnia or restless legs syndrome (RLS). It can help alleviate symptoms such as difficulty falling asleep, frequent awakenings, and nocturnal discomfort.

  7. Side Effects: Common side effects of gabapentin include dizziness, drowsiness, fatigue, blurred vision, dry mouth, weight gain, and peripheral edema. These side effects are usually mild to moderate in severity and often diminish over time with continued use.

  8. Withdrawal Symptoms: Abrupt discontinuation of gabapentin after long-term use may precipitate withdrawal symptoms, including anxiety, agitation, insomnia, nausea, sweating, and tremors. Therefore, gabapentin should be tapered gradually under medical supervision when discontinuing treatment to minimize the risk of withdrawal reactions.

  9. Drug Interactions: Gabapentin may interact with certain medications, such as opioids, benzodiazepines, and other central nervous system depressants, increasing the risk of respiratory depression and sedation. It may also interact with antacids containing aluminum and magnesium, reducing its absorption when taken concomitantly.

  10. Monitoring: Patients taking gabapentin should be monitored regularly for therapeutic response, adverse effects, and signs of misuse or dependence, especially in individuals with a history of substance abuse or addiction.

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Data Contradictions β€” Limits of Certainity

Impacted of gabapentin,(prescription) On Probiotics

Rank Probiotic Impact
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by gabapentin,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Agathobacter genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of gabapentin,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 0.4 0.4
Alzheimer's disease 0.1 1 -9
Ankylosing spondylitis 0 0
Anorexia Nervosa 0.3 -0.3
Atherosclerosis 0 0
Atrial fibrillation 0.3 0.3
Autism 0 0.7 0
Barrett esophagus cancer 0 0
Chronic Fatigue Syndrome 0.4 0.4
Chronic Kidney Disease 0.7 -0.7
Chronic Obstructive Pulmonary Disease (COPD) 0 0
Colorectal Cancer 0.1 0.3 -2
Coronary artery disease 0.3 0.3
COVID-19 0 1 0
Crohn's Disease 0.1 0.7 -6
Depression 0.9 1.5 -0.67
Eosinophilic Esophagitis 0 0
Epilepsy 0 0
gallstone disease (gsd) 0 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0 0
Generalized anxiety disorder 0 0
Halitosis 0 0
Hidradenitis Suppurativa 0 0
Histamine Issues,Mast Cell Issue, DAO Insufficiency 0.3 0.3 0
Inflammatory Bowel Disease 1 -1
Liver Cirrhosis 0 0
Long COVID 0.4 0.4 0
ME/CFS without IBS 0.1 0.1
Metabolic Syndrome 0 0 0
Mood Disorders 0.9 1.5 -0.67
Multiple Sclerosis 0 0.7 0
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.7 -0.7
Obesity 0.5 -0.5
obsessive-compulsive disorder 0.3 -0.3
Parkinson's Disease 0.4 -0.4
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.1 0 0
Sjögren syndrome 0.3 -0.3
Sleep Apnea 0 0
Small Intestinal Bacterial Overgrowth (SIBO) 0 0
Stress / posttraumatic stress disorder 0 0
Systemic Lupus Erythematosus 0 0
Type 2 Diabetes 0 0 0
Ulcerative colitis 0.2 0.2
Unhealthy Ageing 0.1 0.7 -6

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