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Energy Source: Like other sugars, fructose serves as a source of energy for the body. It is metabolized in the liver and converted into glucose, which can be used by cells for energy production.
Blood Sugar Regulation: Fructose has a low glycemic index compared to glucose, meaning it has a slower effect on blood sugar levels. While this may be beneficial for individuals with diabetes or those aiming to manage blood sugar levels, excessive consumption of fructose can still contribute to elevated blood sugar levels over time.
Liver Health: Fructose metabolism primarily occurs in the liver, where it is converted into glucose or stored as glycogen for future energy needs. However, excessive fructose intake, especially in the form of high-fructose corn syrup (HFCS), has been associated with non-alcoholic fatty liver disease (NAFLD) and insulin resistance. This is because fructose metabolism can lead to increased fat accumulation in the liver and contribute to liver inflammation.
Weight Management: High intake of fructose, particularly from added sugars like HFCS, has been linked to weight gain and obesity. Fructose does not stimulate insulin secretion or promote satiety to the same extent as glucose, which may lead to increased calorie intake and weight gain over time.
Metabolic Syndrome: Excessive consumption of fructose has been implicated in the development of metabolic syndrome, a cluster of conditions including obesity, high blood pressure, insulin resistance, and dyslipidemia. These factors increase the risk of type 2 diabetes, cardiovascular disease, and other chronic health conditions.
Gut Health: Some studies suggest that high intake of fructose may disrupt gut microbiota composition and contribute to gastrointestinal symptoms such as bloating, gas, and diarrhea. Fructose malabsorption may occur in some individuals, leading to gastrointestinal discomfort and symptoms of irritable bowel syndrome (IBS).
Cardiovascular Health: While the direct impact of fructose on cardiovascular health is debated, excessive consumption of fructose-rich foods and beverages, especially those containing added sugars, can contribute to an unhealthy diet pattern associated with an increased risk of cardiovascular disease.
Dental Health: Like other sugars, fructose can contribute to tooth decay and cavities when consumed in excess. Bacteria in the mouth feed on sugars, producing acids that erode tooth enamel and lead to dental caries.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Allergic Rhinitis (Hay Fever) | 1 | 1 | |
| Allergies | 0.7 | 0.5 | 0.4 |
| Allergy to milk products | 0.9 | 1 | -0.11 |
| Alzheimer's disease | 1.5 | 1.5 | |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.7 | 0.7 | 1.43 |
| Ankylosing spondylitis | 1.8 | 1.2 | 0.5 |
| Anorexia Nervosa | 0.5 | 0.5 | |
| Antiphospholipid syndrome (APS) | 0.5 | 0.5 | |
| Asthma | 0.5 | 0.5 | 0 |
| Atrial fibrillation | 0.9 | 1.7 | -0.89 |
| Autism | 2.2 | 1.9 | 0.16 |
| benign prostatic hyperplasia | 1 | 1 | |
| Bipolar Disorder | 1.2 | 1.2 | |
| Brain Trauma | 1 | 1 | |
| Carcinoma | 0.7 | 0.7 | |
| Celiac Disease | 0.7 | 0.5 | 0.4 |
| Chronic Fatigue Syndrome | 0.7 | 0.7 | |
| Chronic Kidney Disease | 1 | 1 | |
| Chronic Lyme | 0.5 | 0.5 | |
| Chronic Urticaria (Hives) | 0.9 | 0.9 | |
| Coagulation / Micro clot triggering bacteria | 1.8 | 1.8 | |
| Colorectal Cancer | 2.4 | 2.4 | |
| Constipation | 1.9 | 1.9 | |
| COVID-19 | 1.8 | 1.8 | |
| Crohn's Disease | 2.5 | 0.4 | 5.25 |
| cystic fibrosis | 1.2 | 1.2 | |
| deep vein thrombosis | 1.8 | 1.8 | |
| Depression | 1.9 | 1.5 | 0.27 |
| Eczema | 1.5 | 1.5 | |
| Endometriosis | 1.7 | 1.7 | |
| Epilepsy | 1.2 | 1.2 | |
| Functional constipation / chronic idiopathic constipation | 2.1 | 2.1 | |
| gallstone disease (gsd) | 0.7 | 0.7 | |
| Generalized anxiety disorder | 1.2 | 1.2 | |
| Graves' disease | 0.5 | -0.5 | |
| Hashimoto's thyroiditis | 0.2 | -0.2 | |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.5 | 0.5 | |
| hyperglycemia | 1 | 1 | |
| hypersomnia | 0.2 | 0.2 | |
| hypertension (High Blood Pressure | 1.2 | 0.2 | 5 |
| IgA nephropathy (IgAN) | 0.5 | 0.5 | |
| Inflammatory Bowel Disease | 1.5 | 0.5 | 2 |
| Irritable Bowel Syndrome | 2.4 | 0.7 | 2.43 |
| Liver Cirrhosis | 1.9 | 1.9 | |
| Long COVID | 2.1 | 0.5 | 3.2 |
| Lung Cancer | 1 | 1 | |
| Metabolic Syndrome | 1.9 | 1.9 | |
| Mood Disorders | 1.9 | 2 | -0.05 |
| myasthenia gravis | 0.5 | -0.5 | |
| Neuropathy (all types) | 0.5 | -0.5 | |
| neuropsychiatric disorders (PANDAS, PANS) | 0.2 | 0.2 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.7 | 1.7 | |
| Obesity | 2.2 | 2.2 | |
| obsessive-compulsive disorder | 1.9 | 1.9 | |
| Osteoarthritis | 0.5 | 0.5 | |
| Osteoporosis | 1 | 1 | |
| Parkinson's Disease | 0.9 | 1.2 | -0.33 |
| Polycystic ovary syndrome | 1.5 | 1.5 | |
| Postural orthostatic tachycardia syndrome | 0.5 | 0.5 | |
| Psoriasis | 0.2 | 0.2 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.4 | 0.5 | 3.8 |
| Rosacea | 0.2 | -0.2 | |
| Schizophrenia | 0.2 | 0.5 | -1.5 |
| Sjögren syndrome | 1 | 1 | |
| Sleep Apnea | 1 | 1 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1 | 1 | |
| Stress / posttraumatic stress disorder | 1.2 | 1.2 | |
| Systemic Lupus Erythematosus | 1.9 | 1.9 | |
| Type 1 Diabetes | 0.5 | 0.5 | |
| Type 2 Diabetes | 1.9 | 0.2 | 8.5 |
| Ulcerative colitis | 2.3 | 0.7 | 2.29 |
| Unhealthy Ageing | 0.5 | 0.5 |
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